Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl

Jamali, Amina El; Valente, Anthony J.; Lechleiter, James D.; Gamez, Maria; Pearson, Doran W.; Nauseef, William M.; Clark, Robert A.

doi:10.1016/j.freeradbiomed.2007.11.020

Cited by 102 publications

(95 citation statements)

References 46 publications

(52 reference statements)

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“…5). The ability of the proto-oncogenic kinase C-able to increase Nox5 activity also suggests that it may play an important role in cancers such as leukemia (22). From these findings, it is clear that Nox5 is expressed in certain types of cancers and can contribute to the increased proliferation seen in these cells.…”

Section: Nox5 and Regulation Of Cellular Functionmentioning

confidence: 94%

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Nox5 and the Regulation of Cellular Function

Fulton

2009

Antioxidants & Redox Signaling

137

142

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The NADPH oxidase (Nox) family of enzymes is comprised of seven members, Noxes 1-5 and the Duoxes 1 and 2. Nox5 was the last of the conventional Nox enzymes to be identified, and in comparison to its siblings, much less is known about its molecular regulation and even less regarding its functional significance. The loss of Nox5 from rodent genomes has contributed significantly to this deficit in knowledge, but recent discoveries have narrowed the gap. There are many differences between Nox5 and the other Nox isoforms including alternative splicing, transcriptional regulation, enzymatic control mechanisms, tissue distribution, and intracellular trafficking. The goal of this review is to outline recent advances in our knowledge of the genetic regulation, the molecular mechanisms governing its activity, and the functional significance of Nox5 in human physiology and pathophysiology. Antioxid. Redox Signal. 11, 2443-2452.

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Section: Nox5 and Regulation Of Cellular Functionmentioning

confidence: 94%

“…The proto-oncogenic tyrosine kinase, c-abl, can bind to and increase Nox5 activity via a calciumsensitive, hydrogen peroxide-dependent signaling pathway (22). The functional significance of this with regard to cancer, in particularly chronic myelogenous leukemia, is not well understood.…”

Section: Nox5 and Regulation Of Cellular Functionmentioning

confidence: 99%

Nox5 and the Regulation of Cellular Function

Fulton

2009

Antioxidants & Redox Signaling

137

142

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“…El Jamali et al, on the other hand, reported that H 2 O 2 induced O 2 -production in K562 cells expressing NOX5. This activation was mediated by Ca 2+ -dependent membrane translocation of c-Abl non-receptor tyrosine kinase, and association of NOX5 with c-Abl was suggested (84).…”

Section: Nox5mentioning

confidence: 97%

NOX/NADPH Oxidase, the Superoxide-Generating Enzyme: Its Transcriptional Regulation and Physiological Roles

Katsuyama

2010

J Pharmacol Sci

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Abstract. NADPH oxidase is a superoxide (O 2− )-generating enzyme first identified in phagocytes that shows bactericidal activities. It has been reported that O 2 − is also produced in an NADPHdependent manner in non-phagocytes. In the last decade, non-phagocyte-type NADPH oxidases have been identified, and the catalytic subunit NOX family has been found to be composed of five homologs, NOX1 to NOX5, and two related enzymes, DUOX1 and DUOX2. These NOX proteins have distinct features in dependency on other components for maximal enzymatic activity, tissue distribution, expressional regulation, and physiological functions. This review summarized the distinct characteristics of NOX family proteins, especially focusing on their functions and mechanisms of their expressional regulation.

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“…Hsp90 binds to and regulates Nox5 protein stability (56,126,33). In human endothelial cells (ECs), siRNA-mediated Nox5 knockdown reduced Ang II stimulated ERK1/2 activation, but not that of p38 MAPK or JNK (56 (135,203).…”

Section: Nox5mentioning

confidence: 99%

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

Montezano

Touyz²

2014

Antioxidants & Redox Signaling

235

177

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Significance: Reactive oxygen species (ROS) are signaling molecules that are important in physiological processes, including host defense, aging, and cellular homeostasis. Increased ROS bioavailability and altered redox signaling (oxidative stress) have been implicated in the onset and/or progression of chronic diseases, including hypertension. Recent Advances: Although oxidative stress may not be the only cause of hypertension, it amplifies blood pressure elevation in the presence of other pro-hypertensive factors, such as salt loading, activation of the renin-angiotensin-aldosterone system, and sympathetic hyperactivity, at least in experimental models. A major source for ROS in the cardiovascular-renal system is a family of nicotinamide adenine dinucleotide phosphate oxidases (Noxs), including the prototypic Nox2-based Nox, and Nox family members: Nox1, Nox4, and Nox5. Critical Issues: Although extensive experimental data support a role for increased ROS levels and altered redox signaling in the pathogenesis of hypertension, the role in clinical hypertension is unclear, as a direct causative role of ROS in blood pressure elevation has yet to be demonstrated in humans. Nevertheless, what is becoming increasingly evident is that abnormal ROS regulation and aberrant signaling through redoxsensitive pathways are important in the pathophysiological processes which is associated with vascular injury and target-organ damage in hypertension. Future Directions: There is a paucity of clinical information related to the mechanisms of oxidative stress and blood pressure elevation, and a few assays accurately measure ROS directly in patients. Such further ROS research is needed in humans and in the development of adequately validated analytical methods to accurately assess oxidative stress in the clinic. Antioxid. Redox Signal. 20,[164][165][166][167][168][169][170][171][172][173][174][175][176][177][178][179][180][181][182]

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Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl

Cited by 102 publications

References 46 publications

Nox5 and the Regulation of Cellular Function

Nox5 and the Regulation of Cellular Function

NOX/NADPH Oxidase, the Superoxide-Generating Enzyme: Its Transcriptional Regulation and Physiological Roles

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

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