Novel retinoid ester in combination with salicylic acid for the treatment of acne

BackgroundAcne in women is often associated with anxiety and depression, and may persist from adolescence as well as manifest for the first time in adulthood. Genetic and hormonal factors contribute to its etiopathogenesis, and maintenance treatment is required, usually for years, due to its clinical evolution.ObjectiveTo develop a guide for the clinical practice of adult female acne.MethodsA team of five experts with extensive experience in acne conducted a literature review of the main scientific evidence and met to discuss the best practices and personal experiences to develop a guide containing recommendations for the clinical practice of adult female acne.ResultsThe group of specialists reached consensus on the main guidelines for clinical practice, providing detailed recommendations on clinical picture, etiopathogenesis, laboratory investigation and treatment of adult female acne.ConclusionDifferent from teenage acne, adult female acne presents some characteristics and multiple etiopathogenic factors that make its management more complex. This guide provides recommendations for best clinical practices and therapeutic decisions. However, the authors consider that additional studies are needed in order to provide more evidence for adult female acne to be better understood.

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“…After 4 weeks, improvement was achieved, which remained continuous and cumulative in the eighth week. 102…”

Section: Systemic Treatmentmentioning

confidence: 99%

Adult female acne: a guide to clinical practice

Bagatin

Freitas

Machado

et al. 2019

An. Bras. Dermatol.

113

124

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“…Draelos et al (2016) conducted a study on 27 mild‐moderate acne patients to assess the efficacy and tolerability of a twice daily, three‐product skincare regimen using alpha‐hydroxy acids and retinoids in combination with salicylic acid in acne patients. A statistically significant reduction in inflammatory and non‐inflammatory lesions ( p = 0.006 and p = 0.015, respectively) was observed after 4 weeks and 8 weeks and also there was further improvement (with highly significant decrease; p < 0.001) in both types of lesion counts 15 . Similarly, Leyden et al (2008 and 2012) conducted two separate studies to determine the therapeutic effectiveness of benzoyl peroxide against P .…”

Section: Discussionmentioning

confidence: 97%

“…Favorable outcomes are obtained by combining the alpha-hydroxy acid-induced exfoliation in hydrophilic areas, retinoid-induced normalization of cellular differentiation, and salicylic acid-induced exfoliation in lipophilic areas. 15 Intensive use of antibiotics for a longer duration leads to the increased resistance in acne causing bacteria, that is, P. acnes, S. epidermidis, and S. aureus. 10,16 In addition, allopathic medications for acne may be toxic for body tissue and biological activities of the body.…”

Section: Introductionmentioning

confidence: 99%

Clinical study to assess efficacy and safety of Purifying Neem Face Wash in prevention and reduction of acne in healthy adults

Yogesh

Gajjar

Patel

et al. 2021

J of Cosmetic Dermatology

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Background: Acne vulgaris is a chronic, inflammatory skin condition of pilosebaceous units. The standard treatment involves topical and oral antibiotics, retinoids, benzoyl peroxide, and other synthetic compounds, mostly associated with adverse effects.Hence, herbal skincare products are considered nowadays.Aim: To evaluate the safety and efficacy of Purifying Neem Face Wash (PNFW), an herbal skincare product in the prevention and/or reduction of mild-to-moderate acne.Methods: An open-label, single-center, single-arm, four-week clinical study was conducted with subjects having either mild-to-moderate acne or oily skin and nonexistent acne. The performance of PNFW in the reduction and/or prevention of acne was detected by counting cutaneous inflammatory and non-inflammatory acne lesions in each of the four visits. Sebum level and skin hydration of both cheeks were measured via sebumeter and corneometer, respectively. Self-assessment questionnaires were used to assess the subjects' responses toward PNFW.Results: Out of 120 study subjects, 79% and 72% showed either reduction or no new appearance of inflammatory and non-inflammatory acne lesions, respectively, from baseline to Visits 3 and 4. Skin sebum level and skin hydration showed a statistically significant decrease (p < 0.001) and increase (p < 0.001), respectively, in Visits 3 and 4. Self-assessment surveys showed the satisfaction of the subjects about the product in terms of condition improvement, ease in use, and fragrance. Conclusion:The present study indicated the beneficial effect of the herbal ingredients (neem and turmeric) of Himalaya's PNFW in the prevention and reduction of mild-to-moderate acne with no side effects.

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“…Patient adherence with topical dermatologic regimens is often low particularly when the treatment is poorly tolerated or treatment regimens are complex . The combined efficacy and tolerability profile of AHA‐Ret may contribute to enhanced adherence, ultimately resulting in optimal outcomes and high levels of patient satisfaction.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and tolerability of a double‐conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging

Mazur¹,

Wortzman²,

Nelson³

2017

J of Cosmetic Dermatology

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Novel retinoid ester in combination with salicylic acid for the treatment of acne

Abstract: The topical combination of lactic acid, SA, and AHA-RC produced acne improvement after 4 weeks with continuing cumulative improvement at 8 weeks. AHA-RC represents a new molecule combining several mechanisms of action to achieve acne improvement.

Cited by 20 publications

References 11 publications

Adult female acne: a guide to clinical practice

Adult female acne: a guide to clinical practice

Clinical study to assess efficacy and safety of Purifying Neem Face Wash in prevention and reduction of acne in healthy adults

Efficacy and tolerability of a double‐conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging

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