Novel Route for Synthesis of Anti - Hyperglycaemic Activity of Thiazolidine 2,4- Dione Derivatives As A Mannich Bases

Abstract

The mannish bases of Thiozolidine 2,4 -dione derivatives has come to lime light due to their multi functional biological activities. Thiazolidine-2,4-dione is an extensively explored hetero cyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications ,cancer, arthritis, inflammation, microbial infection, and melanoma. Present work, synthesise quinoline attached imidozoline derivative using (3 +2) cycloaddition via imine of quinoline and TOSMIC. These derivatives were converted to mannich bases of thiozolidine 2,4 one using knoevenagel condensation. The sulfonyl derivatives of thiozolidine 2, 4 -dione were also synthesized and characterized by using alkylation conditions.