Novel ruthenium(<scp>iii</scp>) complexes with hydroxybenzophenones: experimental and theoretical characterization and <i>in vitro</i> leishmanicidal activity comparing complexes and ligands

Dias, Júlia Scaff Moreira; Martins, Felipe Terra; Neto, João Honorato de Araújo; Castellano, Eduardo E.; Viana, Rommel B.; Teixeira, Jéssica da Silva; Guimarães, Elisalva Teixeira; Soares, Milena Botelho Pereira; Barbosa, Marília Imaculada Frazão

doi:10.1039/d0nj06159j

Cited by 2 publications

(4 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Figure , the measured masses ( q e ) of Cr in various MP–Cr–UV filter systems were apparently higher (1.4–5.8 times, Table S6) than those in the MP–Cr systems, implying that MP–Cr interaction was favored by the coexisting UV filter. Such a difference can be understood by integrating knowledge of metal coordination chemistry and multilayer sorption as briefly described as follows: First, model UV filters are derivatives of o -hydroxybenzophenone (Table S1), which are known as chelating ligands that can coordinate with transition metals in a bidentate mode via their carbonyl and phenolate oxygen atoms. − The formed Cr–UV filter complexes may exhibit different sorption behaviors with MP particles as compared to the Cr cations. This hypothesis is supported by the findings of Wang and co-workers, , who demonstrated that the formation of Cu–TC complexes significantly increased the Cu uptake by polyethylene MPs.…”

Section: Resultsmentioning

confidence: 99%

“…From this, it is clearly seen that on both PSMPs the BP-type UV filters with more −OH groups within each pair (i.e., BP-2 and BP-8) exhibited a relatively higher Cr(VI) abundance. A possible explanation for this phenomenon is that the two UV filters contain an additional ortho -hydroxyl group in their benzene rings, which in turn favors their bidentate coordination with Cr(III) cations, and thus, more Cr(III)–organic complexes are formed and being oxidized on the surfaces of PSMPs.…”

Section: Resultsmentioning

confidence: 99%

“…Polystyrene (PS) was used as the model MP since it is one of the polymers most widely identified in microplastic occurrence studies. , Chromium (Cr) was selected as the model metal because it has two stable oxidation states, i.e., Cr(III) and Cr(VI), that exhibit distinctly different chemical and toxicological features . For the model organic chemicals, benzophenone (BP)-type UV filters were chosen because of their ubiquitous occurrence in the aquatic environment , and, even more importantly, because of their ability to coordinate with transition metals to form complexes. − We hypothesized that Cr uptake and their oxidation states when bound to MP particles are being significantly affected by coexisting UV filters. Additionally, we examined the effects of weathering on the interactions of MPs with Cr and UV filters to achieve a more realistic simulation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sorption Behavior, Speciation, and Toxicity of Microplastic-Bound Chromium in Multisolute Systems

Law

et al. 2022

Environ. Sci. Technol. Lett.

View full text Add to dashboard Cite

The unexpectedly high affinity of microplastics (MPs) for heavy metals has attracted increasing attention in recent years. However, there is a scarcity of information on the effects of coexisting constituents on plastic–metal interactions, especially in terms of metal speciation. This study aimed to explore the role of benzophenone-type UV filters on the sorption, oxidation state, and toxicity of chromium (Cr) by pristine and UV-irradiated polystyrene MPs (PSMPs). Results showed that Cr uptake by PSMPs was remarkably higher when UV filters were present. This enhanced affinity was attributed to the formation of Cr–UV filter complexes together with multilayer sorption on PSMPs’ surfaces. Subsequent chemical state measurements indicated alteration of the oxidation state of MP-bound metals as a higher Cr(VI) abundance was identified on the PSMPs with coexisting UV filters. More importantly, our toxicity assessments found that PSMP-bound Cr with a higher oxidation state displayed more severely inhibited microalgae growth. It is noteworthy that toxicological effects of Cr–UV filter complexes were observed only with PSMPs, which thus reaffirms the unique role of MPs in accumulating and transforming contaminants in natural environments. Overall, this study provides the first evidence into the effects of coexisting constituents on the oxidation states and toxicities of MP-bound heavy metals.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sorption Behavior, Speciation, and Toxicity of Microplastic-Bound Chromium in Multisolute Systems

Law

et al. 2022

Environ. Sci. Technol. Lett.

View full text Add to dashboard Cite

show abstract

“…Parasites were counted daily in Neubauer chamber for ve days. When they reached the stationary phase of growth, new in vitro passages of the parasites were performed (Dias et al 2021).…”

Section: Parasite Culturementioning

confidence: 99%

Pharmacological properties of new chalcones for treatment of leishmaniasis: in silico and in vitro studies

Silva

Leite

Herrera‐Acevedo

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Leishmaniasis constitutes a complex of endemic and neglected diseases with high morbidity and mortality rates. Due to the toxicity, resistance profile and adverse effects of current drugs, science is looking for new therapeutic alternatives. Therefore, the objective of this study was to investigate in silico and in vitro tests the leishmanicidal potential of chalcones and verify their influence on the production of Reactive Oxygen Species (ROS). For the in silico tests, the PASS filter program was used. Murine macrophages (J774) and promastigotes and amastigotes of Leishmania braziliensis were used for in vitro tests. The selectivity index (SI) was calculated through the ratio between the 50% cytotoxicity concentration value (CC50) and the 50% inhibitory concentration value (IC50). Evaluation of ROS levels were obtained using the reagent 2'7'-dichlorodihydrofluorescein diacetate (H2DCFDA). The results indicated that one of the biological activities most associated with flavonoids is the antileishmanial activity. All chalcones tested did not show significant cytotoxicity and the chalcone that showed the best antileishmanial potency was compound 4 (FERAI), with a CI50 of 9.75 ± 1.7 µM and 10.13 ± 1.7 µM for promastigotes and amastigotes of L. braziliensis, respectively. Macrophages treated with FERAI showed a reduction in infection and amastigotes number. FERAI has been shown to increase ROS levels, which is one of its possible mechanisms of action against the parasite. In view of the observed results, it is concluded that all compounds did not exhibit significant cytotoxicity and FERAI presented itself as a strong candidate for a new drug against leishmaniasis.

show abstract

Novel ruthenium(iii) complexes with hydroxybenzophenones: experimental and theoretical characterization and in vitro leishmanicidal activity comparing complexes and ligands

Cited by 2 publications

References 86 publications

Sorption Behavior, Speciation, and Toxicity of Microplastic-Bound Chromium in Multisolute Systems

Sorption Behavior, Speciation, and Toxicity of Microplastic-Bound Chromium in Multisolute Systems

Pharmacological properties of new chalcones for treatment of leishmaniasis: in silico and in vitro studies

Contact Info

Product

Resources

About