Novel Scaffold-Based BST-CarGel Treatment Results in Superior Cartilage Repair Compared with Microfracture in a Randomized Controlled Trial

Stanish, William D.; McCormack, Robert G.; Forriol, Francisco; Mohtadi, Nicholas; Pelet, Stéphane; Desnoyers, Jacques; Restrepo, Alberto; Shive, Matthew S.

doi:10.2106/jbjs.l.01345

Cited by 213 publications

(216 citation statements)

References 54 publications

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“…1). Two were randomised controlled trials 1 (RCTs) [15][16][17] and one was a nonrandomised controlled trial (non-RCT) 18 ; with a total of 136 patients (84 in the scaffold and 52 in the control groups). All three studies assessed the clinical effectiveness and safety of…”

Section: Search Resultsmentioning

confidence: 99%

Single-step scaffold-based cartilage repair in the knee: A systematic review

Fischer

Kisser

2016

Journal of Orthopaedics

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Section: Search Resultsmentioning

confidence: 99%

Single-step scaffold-based cartilage repair in the knee: A systematic review

Fischer

Kisser

2016

Journal of Orthopaedics

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“…These technologies may also attempt to leverage growth factors as well (e.g., platelet-rich plasma). Stanish et al reported the first microfracture augmented randomized clinical trial comparing microfracture alone to BST-CarGel (Piramal Life Sciences, Bio-Orthopaedic Division) [15]. BST-CarGel is an example Fig.…”

Section: Microfracture and Augmentationmentioning

confidence: 99%

The state of cartilage regeneration: current and future technologies

Yanke

Chubinskaya

2015

Curr Rev Musculoskelet Med

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It is clear that mature human articular cartilage does not have the innate ability to regenerate. Due to this, much effort has been put forth to work on bestowing this ability. While early data focused on more basic outcomes such as percentage of defect fill, the tissue formed was a "cartilage scar" or "hyaline-like" tissue. Even with more advanced technologies, it is clear that no current procedure is able to reconstitute the native structure and function of true hyaline cartilage. As research advancement has somewhat plateaued in this regard, it is crucial that future work focuses on a multifactorial approach, treating the joint as an organ system. The purpose of this review is to update readers on the most recent literature and controversies surrounding articular cartilage regeneration. Specific focus will be placed on current technologies available in the USA and the basic science to support them.

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“…The chitosan-type liquid membrane (BST-CarGel) creates a different electrical polarity that allows molecular attraction and, therefore, adhesion between the membrane and the chondral surface. 8 It is necessary to slowly and gradually apply the liquid membrane from the upper pole of the lesion, creating a film that finally covers the complete diameter of the chondral defect (Fig 2B). We performed this technique in a cadaveric specimen, together with the repair of 2 concomitant lesions in the external patellar facet joint and in the intercondylar notch.…”

Section: Collagen Membrane Surgical Techniquementioning

confidence: 99%

“…5 The use of these matrixes in a single procedure has facilitated the arthroscopic application of both the MACI [6][7][8] and AMIC techniques. 9 Both techniques have been used for the treatment of femoral condylar [6][7][8][9] or, less frequently, tibial plateau lesions. 10 There are very few reports on the treatment of patellar lesions using these techniques arthroscopically.…”

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confidence: 99%

Arthroscopic Technique for the Treatment of Patellar Chondral Lesions With the Patient in the Supine Position

Cuéllar

Ponte

et al. 2014

Arthroscopy Techniques

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We describe an arthroscopic approach for the treatment of patellar chondral lesions with the patient in the supine position. This approach can be used to perform certain procedures such as matrix autologous chondrocyte implantation and autologous matrixeinduced chondrogenesis. It is possible to perform these arthroscopic techniques working at an angle perpendicular to the patellar joint surface. First, with the patient in the supine position, arthroscopic longitudinal sectioning of the lateral patellar retinaculum is performed, and the patella is reverted with the help of a Codivilla forceps. It is then possible to place the chondral surface perpendicular to the floor, and it can be accessed directly through a lateral parapatellar portal. Short-term follow-up has shown the benignity of opening the patellar retinaculum. This procedure reduces morbidity compared with the traditional open surgery.T he treatment of cartilage lesions in the patellofemoral compartment is controversial. A recent study showed poor results and a significant rate of complications related to standard techniques and a high rate of revision surgery.

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Novel Scaffold-Based BST-CarGel Treatment Results in Superior Cartilage Repair Compared with Microfracture in a Randomized Controlled Trial

Abstract: At twelve months, BST-CarGel treatment resulted in greater lesion filling and superior repair tissue quality compared with microfracture treatment alone. Clinical benefit was equivalent between groups at twelve months, and safety was similar.

Cited by 213 publications

References 54 publications

Single-step scaffold-based cartilage repair in the knee: A systematic review

Single-step scaffold-based cartilage repair in the knee: A systematic review

The state of cartilage regeneration: current and future technologies

Arthroscopic Technique for the Treatment of Patellar Chondral Lesions With the Patient in the Supine Position

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