Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach

Saberi, Arezoo; Kouhjani, Maryam; Mohammadi, Marzieh; Hosta-Rigau, Leticia

doi:10.1186/s12951-023-02115-7

Cited by 10 publications

(2 citation statements)

References 226 publications

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“…3D printers use inorganic materials, while bioprinters use bioinks. [145] 3D bioprinting (3DBP) can be an extension of 3D printing. [139b] It is an emerging additive manufacturing technology in which bioinks are deposited layer by layer.…”

Section: Hydrogels As Ink For Gene Modificationmentioning

confidence: 99%

Hydrogels in Gene Delivery Techniques for Regenerative Medicine and Tissue Engineering

Xu,

Zhang,

Zhu

et al. 2024

Macromolecular Bioscience

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Hydrogels are three‐dimensional networks swollen with water. They are biocompatible, strong, moldable, and are emerging as a promising biomedical material for regenerative medicine and tissue engineering to deliver therapeutic gene. The excellent natural extracellular matrix simulation properties of hydrogels enable them to be co‐cultured with cells or enhance the expression of viral or non‐viral vectors. Its biocompatibility, high strength and degradation performance also make the action process of carriers in tissues more ideal, making it an ideal biomedical material. It has been shown that hydrogel‐based gene delivery technologies have the potential to play therapy‐relevant roles in organs such as bone, cartilage, nerve, skin, reproductive organs, and liver in animal experiments and preclinical trials. This paper reviews recent articles on hydrogels in gene delivery and explains the manufacture, applications, developmental timeline, limitations, and future directions of hydrogel‐based gene delivery techniques.This article is protected by copyright. All rights reserved

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Section: Hydrogels As Ink For Gene Modificationmentioning

confidence: 99%

Hydrogels in Gene Delivery Techniques for Regenerative Medicine and Tissue Engineering

Xu,

Zhang,

Zhu

et al. 2024

Macromolecular Bioscience

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“…On the one hand, it is beneficial to create an optimal microenvironment for accelerated bone defect reconstruction by facilitating rapid blood vessel growth [ 2 ]; on the other hand, sufficient vascularization favors sustained osteogenic activity of osteoblasts, thereby promoting survival of the scaffold [ 3 ]. However, insufficient vascularization of artificial bone repair material remains a challenging problem [ 4 , 5 ]. The porous titanium scaffold, manufactured to mimic natural bone, was characterized by stimulating osteogenesis and vascularization [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell

Wu,

Liu,

et al. 2024

J Nanobiotechnol

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Vascularization plays a significant role in promoting the expedited process of bone regeneration while also enhancing the stability and viability of artificial bone implants. Although titanium alloy scaffolds were designed to mimic the porous structure of human bone tissues to facilitate vascularization in bone repair, their biological inertness restricted their broader utilization. The unique attribute of Metal-organic framework (MOF) MIL-53(Fe), known as “breathing”, can facilitate the efficient adsorption of extracellular matrix proteins and thus provide the possibility for efficient interaction between scaffolds and cell adhesion molecules, which helps improve the bioactivity of the titanium alloy scaffolds. In this study, MIL-53(Fe) was synthesized in situ on the scaffold after hydrothermal treatment. The MIL-53(Fe) endowed the scaffold with superior protein absorption ability and preferable biocompatibility. The scaffolds have been shown to possess favorable osteogenesis and angiogenesis inducibility. It was indicated that MIL-53(Fe) modulated the mechanotransduction process of endothelial cells and induced increased cell stiffness by promoting the adsorption of adhesion-mediating extracellular matrix proteins to the scaffold, such as laminin, fibronectin, and perlecan et al., which contributed to the activation of the endothelial tip cell phenotype at sprouting angiogenesis. Therefore, this study effectively leveraged the intrinsic “breathing” properties of MIL-53 (Fe) to enhance the interaction between titanium alloy scaffolds and vascular endothelial cells, thereby facilitating the vascularization inducibility of the scaffold, particularly during the sprouting angiogenesis phase. This study indicates that MIL-53(Fe) coating represents a promising strategy to facilitate accelerated and sufficient vascularization and uncovers the scaffold-vessel interaction from a biomechanical perspective. Graphical Abstract

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan,

Zhu,

Yang

et al. 2024

Advanced Materials

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The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, and congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these severe bone defects, without incurring prevalent complications associated with conventional autologous or allogeneic bone grafts. 3D printing technology enables control over architectural structures at multiple length scales and has been extensively employed to process biomimetic scaffolds for BTE. In contrast to inert and functional bone grafts, next‐generation smart scaffolds possess a remarkable ability to mimic the dynamic nature of native extracellular matrix (ECM), thereby facilitating bone repair and regeneration. Additionally, they can generate tailored and controllable therapeutic effects, such as antibacterial or antitumor properties, in response to exogenous and/or endogenous stimuli. This review provides a comprehensive assessment of the progress of 3D‐printed smart scaffolds for BTE applications. It begins with an introduction to bone physiology, followed by an overview of 3D printing technologies utilized for smart scaffolds. Notable advances in various stimuli‐responsive strategies, therapeutic efficacy, and applications of 3D‐printed smart scaffolds are discussed. Finally, the review highlights the existing challenges in the development and clinical implementation of smart scaffolds, as well as emerging technologies in this field.

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Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach

Cited by 10 publications

References 226 publications

Hydrogels in Gene Delivery Techniques for Regenerative Medicine and Tissue Engineering

Hydrogels in Gene Delivery Techniques for Regenerative Medicine and Tissue Engineering

Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

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