Novel screen-printed sensors with chemically deposited boron-doped diamond and their use for voltammetric determination of attention deficit hyperactivity disorder medication atomoxetine

Šelešovská, Renáta; Navrátil, Tomáš; Hrdlička, Vojtěch; Michniak, Pavol; Hatala, Michal; Vojs, Marián; Marton, Marián; Matvieiev, Oleksandr; Janíková, Lenka; Chýlková, Jaromíra

doi:10.1016/j.electacta.2021.139642

Cited by 13 publications

(12 citation statements)

References 54 publications

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“…Therefore, it can be concluded that an equal number of electrons and protons were involved in the electrode reaction. The obtained slope value disagrees with the previously published ATX voltammetric methods. , …”

Section: Resultscontrasting

confidence: 88%

“…The estimated values of the limit of quantification (LOQ) and limit of detection (LOD) were 35.0 and 11.55 ng mL −1 , respectively. 55,56 Compared with the previously reported ATX voltammetric methods based on GCE and SP/BDDE as working electro-des, 32,33 the present FeONPs/CPE showed improved sensitivity over a wide linear range. Moreover, the simple fabrication protocol with a prolonged lifetime indicates a promising future of the presented sensors compared with SP/ BDDE sensors (Table S3).…”

Section: Linear Range and Analytical Parametersmentioning

confidence: 81%

“…Based on the Laviron equation, 53 two electrons participated in the electrooxidation of the ATX molecule at the FeONPs/CPE compared with four electrons on GCE and SP/BDDE. 32,33 The reported oxidation pathway of the ATX molecule involved a multistep oxidation process with the formation of the corresponding aldehyde and amine derivatives with the involvement of four electrons and four protons. 32 Herein, based on the present scan rate and pH studies, the oxidation of the ATX molecule includes the transfer of only two electrons and two protons.…”

Section: Electrochemical Behavior At Different Scanmentioning

confidence: 99%

“…In this regard, differential pulse voltammetric methods were reported for ATX based on a glassy carbon electrode (GCE) and screen-printed sensors chemically coated with a borondoped diamond layer (SP/BDDE) with limits of detection of 6.9 × 10 −5 and 3.7 × 10 −8 mol L −1 , respectively. 32,33 With the aim of improved performance and sensitivity, studies were carried out through the integration of the matrix of a voltammetric sensor with different metal oxide nanoparticles. 34−44 Nanostructure-based sensors introduced different opportunities and improved the prospects of the analytical approach with enhanced sensitivity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

“…Based on the electrochemical activity and the presence of oxidizable groups in ATX molecules, voltammetric measurement can be a feasible technique with excellent sensitivity, enhanced selectivity, and easier sample preparation. In this regard, differential pulse voltammetric methods were reported for ATX based on a glassy carbon electrode (GCE) and screen-printed sensors chemically coated with a boron-doped diamond layer (SP/BDDE) with limits of detection of 6.9 × 10 –5 and 3.7 × 10 –8 mol L –1 , respectively. , …”

Section: Introductionmentioning

confidence: 99%

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Novel Iron Oxide Nanoparticle-Fortified Carbon Paste Electrode for the Sensitive Voltammetric Determination of Atomoxetine

et al. 2023

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Herein, the fabrication and full characterization of a novel atomoxetine (ATX) voltammetric carbon paste electrode (CPE) fortified with iron oxide nanoparticles (FeONPs) is demonstrated. Modification of the carbon paste matrix with the metallic oxide nanostructure provides proper electrocatalytic activity against the oxidation of ATX molecules at the carbon paste surface, resulting in a noticeable improvement in the performance of the sensor. At the recommended pH value, ATX recorded an irreversible anodic peak at 1.17 V, following a diffusion-controlled reaction mechanism. Differential pulse voltammograms exhibited peak heights linearly correlated to the ATX content within a wide concentration range from 45 to 8680 ng mL–1, with the limit of detection reaching 11.55 ng mL–1. The electrooxidation mechanism of the ATX molecule was proposed to be the oxidation of the terminal amino group accompanied by the transfer of two electrons and two protons. The fabricated FeONPs/CPE sensors exhibited enhanced selectivity and sensitivity and therefore can be introduced for voltammetric assaying of atomoxetine-indifferent pharmaceutical and biological samples in the presence of its degradation products and metabolites.

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Section: Resultscontrasting

confidence: 88%

Section: Linear Range and Analytical Parametersmentioning

confidence: 81%

Section: Electrochemical Behavior At Different Scanmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel Iron Oxide Nanoparticle-Fortified Carbon Paste Electrode for the Sensitive Voltammetric Determination of Atomoxetine

et al. 2023

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Electro-analysis Using Unmodified Boron Doped Diamond Electrodes

Scorsone

2024

Topics in Applied Physics

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Boron-doped diamond nanosheet volume-enriched screen-printed carbon electrodes: a platform for electroanalytical and impedimetric biosensor applications

Ficek,

Cieślik,

Janik

et al. 2023

Microchim Acta

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This paper focuses on the development of a novel electrode based on boron-doped diamond nanosheet full-volume-enriched screen-printed carbon electrodes (BDDPE) for use as an impedimetric biosensor. Impedimetric biosensors offer high sensitivity and selectivity for virus detection, but their use as point-of-care devices is limited by the complexity of nanomaterials’ architecture and the receptor immobilisation procedures. The study presents a two-step modification process involving the electroreduction of diazonium salt at the BDDPE and the immobilisation of antibodies using zero-length cross-linkers for a selective impedimetric biosensor of Haemophilus influenzae (Hi). The incorporation of diamond nanosheets into BDDPE leads to enhanced charge transfer and electrochemical behaviour, demonstrating greatly improved electrochemically active surface area compared with unmodified screen-printed electrodes (by 44% and 10% on average for [Ru(NH3)6]Cl2 and K3[Fe(CN)6], respectively). The presented sensing system shows high specificity towards protein D in Hi bacteria, as confirmed by negative controls against potential interference from other pathogens, with an estimated tolerance limit for interference under 12%. The Hi limit of detection by electrochemical impedance spectroscopy was 1 CFU/mL (measured at − 0.13 V vs BDDPE pseudo-reference), which was achieved in under 10 min, including 5 min sample incubation in the presence of the analyte. Graphical abstract

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Novel screen-printed sensors with chemically deposited boron-doped diamond and their use for voltammetric determination of attention deficit hyperactivity disorder medication atomoxetine

Cited by 13 publications

References 54 publications

Novel Iron Oxide Nanoparticle-Fortified Carbon Paste Electrode for the Sensitive Voltammetric Determination of Atomoxetine

Novel Iron Oxide Nanoparticle-Fortified Carbon Paste Electrode for the Sensitive Voltammetric Determination of Atomoxetine

Electro-analysis Using Unmodified Boron Doped Diamond Electrodes

Boron-doped diamond nanosheet volume-enriched screen-printed carbon electrodes: a platform for electroanalytical and impedimetric biosensor applications

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