Novel self-assembling peptide hydrogel with pH-tunable assembly microstructure, gel mechanics and the entrapment of curcumin

Chen, Huimin; Zhang, Tianrui; Tian, Yongtao; You, Lijun; Huang, Yan; Wang, Shaoyun

doi:10.1016/j.foodhyd.2021.107338

Cited by 28 publications

(15 citation statements)

References 82 publications

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“…Inspired by amino acid pairing peptides and peptide amphiphilies, we have designed several novel APPs with self-assembly ability and pH response performance. 14 The structure of pentapeptides sequence is hydrophobic in the middle and hydrophilic at both ends. For the self-assembly of APPs, electrostatic interaction was one of the important roles of peptide self-assembly.…”

Section: Resultsmentioning

confidence: 99%

pH-Switchable Antimicrobial Supramolecular Hydrogels for Synergistically Eliminating Biofilm and Promoting Wound Healing

Chen

Cheng

Cai

et al. 2022

ACS Appl. Mater. Interfaces

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Biofilm infection will cause chronic inflammation and hinder the normal healing process of wound. Here, based on the self-assembly of three designed amphiphilic pentapeptides named EK, GG, and DR, pH-switchable antibacterial hydrogels with amphiphilic fiber network are used for the eradication of biofilms and the rescue of delayed healing in infected wounds. These pentapeptides-based hydrogels exhibit an acidic pHswitchable antimicrobial effect and are biocompatible at neutral pH. Additionally, supramolecular nanofiber networks with physical cross-linking with thermosensitive polymers (PNIPAm) and loaded antibacterial oregano oil are further developed. In vitro experiments indicate that the antimicrobial activity of hydrogels comes from the disassembly of acidic pH-dependent nanofiber network and activated release of pentapeptides and oregano oil, which achieves synergistic biofilm eradication. Remarkably, DRbased supramolecular hydrogel improves the healing efficiency of the full-thickness wound of skin in vivo, which is manifested by increased wound closure rate, reduced inflammatory response, faster angiogenesis, and collagen deposition in the wound, exhibiting great potential as wound dressing. The proposed synergistic strategy of inhibiting biofilm formation and activating healing may provide an efficient method for the treatment of clinically infected wounds.

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Section: Resultsmentioning

confidence: 99%

pH-Switchable Antimicrobial Supramolecular Hydrogels for Synergistically Eliminating Biofilm and Promoting Wound Healing

Chen

Cheng

Cai

et al. 2022

ACS Appl. Mater. Interfaces

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“…The relationship of ln I ( q ) – q 2 was a concave curve with almost no straight segments in the low q 2 region (0–1 nm –2 ), as shown in Figure S2 of the Supporting Information. This means that aggregates in samples had a complex non-spherical polydispersed morphology . The curve of SAXS for the hydrogel in a low range of scatter vector ( q ) showed a gradient of approximately −1.9959, which is shown in Figure a.…”

Section: Resultsmentioning

confidence: 93%

“…This means that aggregates in samples had a complex non-spherical polydispersed morphology. 40 The curve of SAXS for the hydrogel in a low range of scatter vector (q) showed a gradient of approximately −1.9959, which is shown in Figure 4a. In comparison to the solution of YAFAF in HFIPA (q = −0.0335), features of the scattering functions of the YAFAF hydrogel indicated a lamellar nanostructure.…”

Section: Yafaf-based Hydrogel Morphologymentioning

confidence: 95%

YAFAF-Based Hydrogel: Characterization, Mechanism, and Factors Influencing Micro-organization

Wang

Lü

et al. 2022

J. Agric. Food Chem.

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The YAFAF-based hydrogel was a three-dimensional network cross-linked by grooved fiber bundles. The fiber bundles were formed by entanglement of fibrils with a diameter of 2 nm, and the surface of the fibrils also presented grooves. Spectroscopic analysis revealed that the main secondary structures were β-sheets and β-turns, which led to the grooved feature of fibrils. In comparison of the nuclear magnetic resonance spectra of peptide solutions at 313 and 277 K, the nuclear Overhauser effects can be clearly observed, indicating that hydrogen-bondings and π–π stacking interactions play important roles in self-assembly. The micro-organization of the self-assemblies was affected by the ratio of solvents (x A) remarkably. Unexpectedly, x A of 0.05 produced hollow spherical aggregates. The result of these investigations on the mechanism and organization of the YAFAF-based hydrogel can contribute to the development of strategies using hydrogels in the food industry.

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“…Pentapeptide hydrogels are of great importance in terms of synthesis and biological applications [ 47 ]. Chen et al reported a family of pentapeptide hydrogels and studied the thermodynamics, gelation kinetics, and ionization status of terminal groups of the pentapeptides, reporting that the structures of the hydrogels are highly dependent on the charging status of the terminal groups [ 48 ]. Moreover, they encapsulated a hydrophobic functional molecule (curcumin) inside the nanostructures with high efficiency and significant protection of the drug against thermal and light degradation.…”

Section: Introductionmentioning

confidence: 99%

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

et al. 2022

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Peptide-based hydrogels have attracted increasing attention for biological applications and diagnostic research due to their impressive features including biocompatibility and biodegradability, injectability, mechanical stability, high water absorption capacity, and tissue-like elasticity. The aim of this review will be to present an updated report on the advancement of peptide-based hydrogels research activity in recent years in the field of anticancer drug delivery, antimicrobial and wound healing materials, 3D bioprinting and tissue engineering, and vaccines. Additionally, the biosensing applications of this key group of hydrogels will be discussed mainly focusing the attention on cancer detection.

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Novel self-assembling peptide hydrogel with pH-tunable assembly microstructure, gel mechanics and the entrapment of curcumin

Cited by 28 publications

References 82 publications

pH-Switchable Antimicrobial Supramolecular Hydrogels for Synergistically Eliminating Biofilm and Promoting Wound Healing

pH-Switchable Antimicrobial Supramolecular Hydrogels for Synergistically Eliminating Biofilm and Promoting Wound Healing

YAFAF-Based Hydrogel: Characterization, Mechanism, and Factors Influencing Micro-organization

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

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