2021
DOI: 10.1007/s00294-021-01185-0
|View full text |Cite
|
Sign up to set email alerts
|

Novel self-regulation strategy of a small heat shock protein for prodigious and rapid expression on demand

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
5
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
3
1

Relationship

2
2

Authors

Journals

citations
Cited by 4 publications
(5 citation statements)
references
References 21 publications
0
5
0
Order By: Relevance
“…S3 ). Given the prevalent occurrence of RNAT-mediated sHsp translation regulation in α- and γ-proteobacteria but not in gram-positive bacteria ( 9 , 10 ), R93 potentially exhibits a comparable significance in both α- and γ-proteobacterial IbpAs as it does in IbpA Ec .
Figure 2 Conservation of self-translation regulation and the critical residue in other bacterial IbpAs.
…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…S3 ). Given the prevalent occurrence of RNAT-mediated sHsp translation regulation in α- and γ-proteobacteria but not in gram-positive bacteria ( 9 , 10 ), R93 potentially exhibits a comparable significance in both α- and γ-proteobacterial IbpAs as it does in IbpA Ec .
Figure 2 Conservation of self-translation regulation and the critical residue in other bacterial IbpAs.
…”
Section: Resultsmentioning
confidence: 99%
“…Bacterial sHsps are upregulated by a sigma factor σ 32 at the transcriptional level upon heat shock ( 8 ). Moreover, in α- and γ-proteobacteria, sHsps are translationally regulated by a thermosensitive mRNA structure (RNA thermometer, [RNAT]) in the 5′-untranslated region (5′ UTR), which contains the element of heat shock gene expression repression ( 9 , 10 ). The elements, ranging in length from 60 to over 100 nucleotides, typically consist of two to four stem-loops, which play a critical role in the modulation of sHsp translation ( 11 ).…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Bacterial sHsps are upregulated by a sigma factor σ 32 , at the transcriptional level upon heat shock (8). Moreover, in αand γ-proteobacteria, sHsps are translationally regulated by a thermo-sensitive mRNA structure (RNA thermometer, RNAT) in the 5'-untranslated region (5' UTR), which contains the element of heat shock gene expression repression (9,10). The elements, ranging in length from 60 to over 100 nucleotides, typically consist of 2 to 4 stem-loops, which play a critical role in the modulation of sHsp translation (11).…”
Section: Introductionmentioning
confidence: 99%
“…The IbpA-mediated translation suppression is relieved by aggregation-prone client proteins that recruit IbpA Ec , thereby reducing the amount of IbpA Ec involved in self-suppression (18). The nonconventional function of IbpA Ec as an aggregation-sensor tightly suppresses IbpA Ec expression under aggregationfree conditions but enables cells to rapidly up-regulate the IbpA Ec levels upon acute aggregation stress, such as heat shock (10,18).…”
Section: Introductionmentioning
confidence: 99%