Novel sensor for the determination of CA 15-3 in serum of breast cancer patients based on Fe–gallic acid complex doped in modified cellulose polymer thin films

Alghamdi, Hanan M.; AlZahrani, Yasmeen M.; Alharthi, Salha; Eldin, M.S. Mohy; Mohamed, Ekram H.; Mahmoud, S.A.Z.; Attia, M. S.

doi:10.1039/d3ra02495d

Cited by 8 publications

(1 citation statement)

References 70 publications

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“…A comparative analysis with previously published techniques showcases the superiority of our sensor. It demonstrates exceptional stability, a significantly lower LOD, and a broader linear range, solidifying its potential for clinical applications. − In conclusion, this study offers a multifaceted exploration of the terbium complex-doped epoxy cellulose polymer sensor’s interaction with CA-125. The unveiled quenching mechanism, dominated by static quenching with a possible FRET component, lays the groundwork for future optimization.…”

Section: Resultsmentioning

confidence: 86%

Polymer-Based Terbium Complex as a Fluorescent Probe for Cancer Antigen 125 Detection: A Promising Tool for Early Diagnosis of Ovarian Cancer

Mohamed,

Gamal,

El-Didamony

et al. 2024

ACS Omega

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A novel photoprobe, Tb–acetylacetone (Tb–ACAC) doped within a modified epoxy cellulose polymer immobilized with CA-125 monoclonal antibody, offers an accurate and highly selective method for early ovarian cancer (OC) diagnosis by detecting cancer antigen 125 (CA-125) in serum samples. This approach leverages quenching of the Tb–ACAC luminescence upon binding to CA-125. Characterization of the photoprobe film through UV–vis and fluorescence measurements confirmed the presence of Tb–ACAC within the polymer matrix. In aqueous solution (pH 6.8, λex = 365 nm), the characteristic emission band of Tb–ACAC at λem = 546.2 nm exhibited significant quenching upon CA-125 binding. This quenching effect enabled the sensitive and specific detection of CA-125 in diverse serum samples from OC patients, demonstrating the applicability, simplicity, and effectiveness of this novel approach.

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Section: Resultsmentioning

confidence: 86%

Polymer-Based Terbium Complex as a Fluorescent Probe for Cancer Antigen 125 Detection: A Promising Tool for Early Diagnosis of Ovarian Cancer

Mohamed,

Gamal,

El-Didamony

et al. 2024

ACS Omega

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Enhancing electrochemical detection through machine learning-driven prediction for canine mammary tumor biomarker with green silver nanoparticles

Enginler,

Küçükdeniz,

Dal

et al. 2024

Anal Bioanal Chem

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This study developed an innovative biosensor strategy for the sensitive and selective detection of canine mammary tumor biomarkers, cancer antigen 15–3 (CA 15–3) and mucin 1 (MUC-1), integrating green silver nanoparticles (GAgNPs) with machine learning (ML) algorithms to achieve high diagnostic accuracy and potential for noninvasive early detection. The GAgNPs-enhanced electrochemical biosensor demonstrated selective detection of CA 15–3 in serum and MUC-1 in tissue homogenates, with limits of detection (LODs) of 0.07 and 0.11 U mL−1, respectively. The nanoscale dimensions of the GAgNPs endowed them with electrochemically active surface areas, facilitating sensitive biomarker detection. Experimental studies targeted CA 15–3 and MUC-1 biomarkers in clinical samples, and the biosensor exhibited ease of use and good selectivity. Furthermore, ML algorithms were employed to analyze the electrochemical data and predict biomarker concentrations, enhancing the diagnostic accuracy. The Random Forest algorithm achieved 98% accuracy in tumor presence prediction, while an Artificial Neural Network attained 76% accuracy in CA 15–3-based tumor grade classification. The integration of ML techniques with the GAgNPs-based biosensor offers a promising approach for noninvasive, accurate, and early detection of canine mammary tumors, potentially revolutionizing veterinary diagnostics. This multilayered strategy, combining eco-friendly nanomaterials, electrochemical sensing, and ML algorithms, holds significant potential for advancing both biomedical research and clinical practice in the field of canine mammary tumor diagnostics. Graphical Abstract

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Poly(aniline-co-pyrrole) incorporated Ag@Ag2MoO4 nanocomposites: In situ synthesis and nanomolar detection of environmental pollutant 4-nitrophenol

Selvamani,

Annamalai,

Dahlous

et al. 2024

Electrochimica Acta

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Novel sensor for the determination of CA 15-3 in serum of breast cancer patients based on Fe–gallic acid complex doped in modified cellulose polymer thin films

Abstract: Fe–gallic acid MOF embedded in an epoxy methyl cellulose polymer (CMC) thin film was synthesized and characterized by different micro-analytical tools such as: FE-SEM/EDX, XPS analysis, XRD analysis, FT-IR, and fluorescence spectroscopy.

Cited by 8 publications

References 70 publications

Polymer-Based Terbium Complex as a Fluorescent Probe for Cancer Antigen 125 Detection: A Promising Tool for Early Diagnosis of Ovarian Cancer

Polymer-Based Terbium Complex as a Fluorescent Probe for Cancer Antigen 125 Detection: A Promising Tool for Early Diagnosis of Ovarian Cancer

Enhancing electrochemical detection through machine learning-driven prediction for canine mammary tumor biomarker with green silver nanoparticles

Poly(aniline-co-pyrrole) incorporated Ag@Ag2MoO4 nanocomposites: In situ synthesis and nanomolar detection of environmental pollutant 4-nitrophenol

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