Novel sensory trigger for gastrocolonic response

Abstract

The gastrocolonic response (GCR), often referred to as gastrocolonic reflex, describes a physiologic increase in motor activity of the colon following meal ingestion, which was first described by Cannon in 1902, with the term GCR being proposed by Hertz a few years later. 1,2 The increase in colonic motor activity from baseline maybe subtle or more pronounced, mostly in younger children, resulting in high amplitude propagated contractions (HAPC). 3 The response propagates fecal content and gas throughout the colon and allows new intestinal content to enter the colon. It is typically noted within minutes after meal ingestion. 4 This physiologic response is used as a marker of an intact neuromuscular interaction between the central and enteric nerval system (ENS) in colonic manometry studies. 5 The exact stimuli and pathway of the GCR remain unclear. The vagus nerve was shown to have a stimulatory effect on the GCR. 6 The GCR is evoked by gastric distention and by lipid infusion into the

Diagnostic yield of left‐sided colonic manometry in identifying colonic dysmotility in pediatric patients

“…However, in specific cases of pan‐colonic dysmotility, limited left CM reflected motility of the entire colon, such as in cases of colonic hyperactivity and in cases of abnormal gastrocolonic response. These conditions apparently seem to affect the entire colon but can be identified through a segmental analysis, as was previously demonstrated 18 . Suggested protocol for evaluation of left CM in pediatric patients, based on our study results, is presented in Figure 5.…”

“…These conditions apparently seem to affect the entire colon but can be identified through a segmental analysis, as was previously demonstrated. 18 Suggested protocol for evaluation of left CM in pediatric patients, based on our study results, is presented in Figure 5.…”

Comparing surface electroenterography measurements between patients suffering from Hirschsprung’s disease and controls: a feasibility study

“…Earlier research, using intraluminal EEnG measurements, has shown that children suffering from HSCR exhibited no slow wave colonic activity as opposed to healthy controls, in whom slow wave colonic activity was present 14 . Additionally, Dorfman et al documented an increase in colonic activity upon meal intake in children using colonic manometry recordings 15 . Our contradicting results may be explained by the fact that newborns and young children were not capable to lie completely still during both 20-minte sEEnG recordings.…”