Novel serological biomarker models composed of bone turnover markers, vitamin D, and estradiol and their auxiliary diagnostic value in girls with idiopathic central precocious puberty

Does vitamin D have a potential role in precocious puberty? A meta-analysis

“…A total of 43 studies met the criteria for inclusion, which included 10 755 subjects and most of them were girls 9,10, (Tables 1 and 2). Among them, the differences in serum vitamin D concentrations and the risk of precocious puberty were analyzed in 35 9,10,18,[20][21][22][23][24][25][26][28][29][30][31][32][33][36][37][38]40,43,44,[46][47][48][49][50][51][52][53][54][55][56][57][58] and 14 9,10,[18][19][20]25,31,40,48,52,53,[56][57]…”

“…A total of 43 studies met the criteria for inclusion, which included 10 755 subjects and most of them were girls 9,10,18–58 (Tables 1 and 2). Among them, the differences in serum vitamin D concentrations and the risk of precocious puberty were analyzed in 35 9,10,18,20–26,28–33,36–38,40,43,44,46–58 and 14 9,10,18–20,25,31,40,48,52,53,56–58 studies, respectively. The average score of NOS in these contained studies was 7.56 (range 6–9), and the grades of evidence were deemed to be of medium quality by the GRADE system (Table S2†).…”

“…8 In particular, population-based epidemiological studies and clinical trials have found that low serum 25-hydroxyvitamin D levels are closely related to precocious puberty. 9,10 Vitamin D is a potential regulator of neuroendocrine and ovarian physiology, and its sufficiency is necessary for the transition of puberty and proper maintenance of reproductive physiology. Meanwhile, vitamin D levels may affect the secretion of sex hormones in children, participate in the development of children's gonads, and regulate the growth and function of generative organs.…”