Novel slow drug release bioceramic composite materials for wound dressing applications: potential of natural materials

Abstract

There is a need for friendly and affordable wound dressing materials capable of uptaking and releasing active clinical agents. Proper combinations of materials that could quickly release antibiotics at the beginning, then slow and controlled release with time would make excellent materials for wound care management. In this study, cotton handwoven fabric hydroxyapatite (derived from coralline skeletons) polylactic acid composites were developed. The developed composites were characterized in terms of their physical and mechanical properties. Also, the in vitro drug release profiles for the developed composites were established. Bacteria efficacy of natural antimicrobial agents loaded composites against gram-positive bacteria Staphylococcus aureus (S. aureus) was also studied. The results suggested that the hand-weaving method has the potential to control the porosity of the fabric for different applications. Woven fabric with 1 mm pore sizes is suggested to have better particle uptake properties and moderate mechanical and physical properties suitable for wound dressing applications. Particle embedment capacity (w/w %) seemed to increase as the fabric pore sizes increases. On the other hand fabric with 1 mm pore sizes uptakes the highest amount of particles (0.174 g). A combination of coralline derived hydroxyapatite particles with cotton fabric suggested controlling the drug release rate by 30% compared with the fabric without the particles, appropriate for prolonged drug release applications. The released drug and natural antimicrobial agents from the developed composites suggested inhibiting microbial growth in which honey performed close to a clinical antibiotic. It was recommended to conduct an in vivo study for the developed composite.

Bioactive Glasses: A Promising Therapeutic Ion Release Strategy for Enhancing Wound Healing

“…It is reported that coral-derived hydroxyapatite particles loaded with amoxicillin drug can be used as drug delivery systems in a wound dressing. 318 Smectite and akermanite have been showed to affect different stages of wound healing by releasing bioactive ions. 204,319 Magnesium smectite led to accelerate neovascularization, collagen deposition and maturation.…”

“…It is worth mentioning that a number of studies have also reported the use of bioactive ceramics, including hydroxyapatite and silicates such as magnesium silicate (smectite) and calcium magnesium silicate (akermanite) in wound healing research field. It is reported that coral-derived hydroxyapatite particles loaded with amoxicillin drug can be used as drug delivery systems in a wound dressing . Smectite and akermanite have been showed to affect different stages of wound healing by releasing bioactive ions. , Magnesium smectite led to accelerate neovascularization, collagen deposition and maturation .…”

“…Among biomaterial-based approaches, the application of inorganic materials such as bioactive glasses is suited for improving wound repair and regeneration because they can act as ion delivery systems to possess the anti-inflammatory, antibacterial, pro-angiogenic and hemostatic activity and also exerting several biological impacts on cell functions such as cell proliferation, migration, and differentiation. It is worth mentioning that a number of studies have also reported the use of bioactive ceramics, including hydroxyapatite and silicates such as magnesium silicate (smectite) and calcium magnesium silicate (akermanite) in wound healing research field. It is reported that coral-derived hydroxyapatite particles loaded with amoxicillin drug can be used as drug delivery systems in a wound dressing .…”