Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits

Guo, Yue-Liang Leon; Chen, Hong; Lan, Xianyong; Bao, Zhenan; Pan, Chuanying; Zhang, Liangzhi; Zhang, Cunfang; Zhao, Miao

doi:10.1007/s10528-008-9197-z

Cited by 29 publications

(21 citation statements)

References 13 publications

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“…In addition, a polymorphism in exon 3 of the leptin gene is related to body weight at 210 days of age and the average daily gain between 3 and 210 days of age in Limousin calves (Kulig and Kmieć, 2009). Guo et al (2008b) also reported an association between a polymorphism of the leptin receptor and growth traits in Nanyang cattle, in contrast to our results.…”

Section: Discussioncontrasting

confidence: 99%

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

et al. 2015

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ABSTRACT. Backfat thickness (BFT) and ribeye area (REA) are important production traits but, because they are measured late in the animal's life, they have not been efficiently included in breeding programs. The aim of this study was to evaluate whether single nucleotide polymorphisms (SNPs) mapped to the leptin, PPARGC1A, PSMC1, CRH, and FABP4 genes, which influence BFT and REA in Canchim cattle, a composite beef breed (5/8 Charolais + 3/8 Zebu). BFT and REA phenotypic records were obtained by ultrasound measurements from 18-month-old animals. All SNP markers were genotyped by restriction fragment length polymorphismpolymerase chain reaction. Restricted maximum likelihood analysis revealed that the non-synonymous SNP located in exon 2 of the FABP4 gene has an additive effect on BFT (P ≤ 0.05). Significant allele substitution 16668©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16667-16674 (2015) G. Veneroni-Gouveia et al. effects showed that the substitution of G by A may lead to a decrease of 0.1055 mm in mean BFT. This information can be used for inclusion of this trait-associated marker in commercial SNP panels.

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Section: Discussioncontrasting

confidence: 99%

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

et al. 2015

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“…Almeida et al (2008) investigated it in Angus, Brangus and Charolais cows and found no associations with reproductive characteristics. Schenkel et al (2006) reported only one LEPR SNP associated with s.c. fat mass, fat yield and fat grade in beef cattle but Guo et al (2008) genotyped LEPR exon 4 SNP in five Chinese breeds and found strong influences on height, weight, length and weight gain at 6 and 12 months. Vincent et al (1997) first reported a polymorphism in porcine LEPR, one of several genes linked to fat deposition in pigs (Ovilo et al, 2005).…”

Section: Leptin Receptor Gene Snpsmentioning

confidence: 96%

Leptin in farm animals: where are we and where can we go?

Wylie

2011

Animal

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Fat affects meat quality, value and production efficiency as well as providing energy reserves for pregnancy and lactation in farm livestock. Leptin, the adipocyte product of the obese (ob) gene, was quickly seen as a predictor of body fat content in animals approaching slaughter and an aid to assessing reproductive readiness in females. Its participation in inflammation and immune responses that help animals survive infection and trauma has clear additional relevance to meat and milk production. Furthermore, almost a decade of discoveries of nucleotide polymorphisms in the leptin and leptin receptor genes has suggested useful applications relating to feed intake regulation, the efficiency of feed use, the composition of growth, the timing of puberty, mammogenesis and mammary gland function and fertility in cattle, pigs and poultry. The current review attempts to summarise where research has taken us in each of these aspects and speculates on where future research might lead.Keywords: leptin, farm animals, production efficiency, fat, body composition ImplicationsLeptin has not yet delivered the initial expectations of animal scientists eager for a robust and reliable marker of body and carcase fat in farm livestock, but its close association with fat and fat deposition continue to cast it as a potential aid for enhancing production efficiency, reproductive success and immune function. Polymorphisms in the leptin and leptin receptor genes provide powerful additional tools for enhanced selection to meet aspirations for increased global animal production within an overarching need to contain and reduce environmental impacts. IntroductionFat is important in all livestock production as it affects product quality and production efficiency and provides the energy reserves for pregnancy and lactation. The discovery of the obese (ob) gene and its product leptin (Zhang et al., 1994;Halaas et al., 1995) and their links to body fat (Frederich et al., 1995;Maffei et al., 1995) excited animal scientists, who quickly saw potential for leptin as a predictor of body composition in animals approaching slaughter and of reproductive readiness in females (Hossner, 1998). Its involvement in inflammation and in the immune responses that help animals survive infection and trauma, also has clear relevance and attention turned to using leptin, directly or indirectly, to influence production characteristics with feed intake, body composition, puberty, mammary gland function, immune response and the reproductive pathway all possible targets. Associations of production traits with polymorphisms in the leptin and leptin receptor genes pointed to additional applications.Among the many reviews of leptin, those by ), Baile et al. (2000, Ingvartsen and Boisclair (2001), Chilliard et al. (2005) and Barb et al. (2006) stand out as most relevant to livestock with Williams et al. (2002), Barb and Kraeling (2004), Barb et al. (2005) and Zieba et al. (2005) emphasising its involvement in reproduction. Those by Ahima and Flier (2000) and Harris (200...

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“…Several studies have investigated associations between SNP in the leptin system with growth, milk production and fertility traits. DeVuyst et al (2008) reported an association between a leptin SNP and weaning weight in crossbred calves, while polymorphisms in the leptin receptor were associated with growth traits in Nanyang cattle, where they had significant effects on height, length, heart girth, weight and ADG at 6 and 12 months of age (Guo et al, 2008). Mixed model analyses revealed that leptin SNP in Holstein-Friesian heifers were similarly associated with early skeletal growth and also with fertility and subsequent milk production (Clempson et al, 2011).…”

Section: Genetic Selectionmentioning

confidence: 99%

Heifer fertility and carry over consequences for life time production in dairy and beef cattle

Wathes

Pollott

Johnson

et al. 2014

Animal

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116

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The rearing period has a key influence on the later performance of cattle, affecting future fertility and longevity. Producers usually aim to breed replacement heifers by 15 months to calve at 24 months. An age at first calving (AFC) close to 2 years (23 to 25 months) is optimum for economic performance as it minimises the non-productive period and maintains a seasonal calving pattern. This is rarely achieved in either dairy or beef herds, with average AFC for dairy herds usually between 26 and 30 months. Maintaining a low AFC requires good heifer management with adequate growth to ensure an appropriate BW and frame size at calving. Puberty should occur at least 6 weeks before the target breeding age to enable animals to undergo oestrous cycles before mating. Cattle reach puberty at a fairly consistent, but breed-dependent, proportion of mature BW. Heifer fertility is a critical component of AFC. In US Holsteins the conception rate peaked at 57% at 15 to 16 months, declining in older heifers. Wide variations in growth rates on the same farm often lead to some animals having delayed first breeding and/or conception. Oestrous synchronisation regimes and sexed semen can both be used but unless heifers have been previously well-managed the success rates may be unacceptably low. Altering the nutritional input above or below those needed for maintenance at any stage from birth to first calving clearly alters the average daily gain (ADG) in weight. In general an ADG of around 0.75 kg/day seems optimal for dairy heifers, with lower rates delaying puberty and AFC. There is some scope to vary ADG at different ages providing animals reach an adequate size by calving. Major periods of nutritional deficiency and/or severe calfhood disease will, however, compromise development with long-term adverse consequences. Infectious disease can also cause pregnancy loss/abortion. First lactation milk yield may be slightly lower in younger calving cows but lifetime production is higher as such animals usually have good fertility and survive longer. There is now extensive evidence that as long as the AFC is > 23 months then future performance is not adversely influenced. On the other hand, delayed first calving > 30 months is associated with poor survival. Underfeeding of young heifers reduces their milk production potential and is a greater problem than overfeeding. Farmers are more likely to meet the optimum AFC target of 23 to 25 months if they monitor growth rates and adjust feed accordingly.

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Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits

Cited by 29 publications

References 13 publications

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed

Leptin in farm animals: where are we and where can we go?

Heifer fertility and carry over consequences for life time production in dairy and beef cattle

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