Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia

Piper, Kim; Ball, Steve; Keeling, Jean W.; Mansoor, Samina; Wilson, David I.; Hanley, Neil A.

doi:10.1016/s0925-4773(02)00145-4

Cited by 90 publications

(89 citation statements)

References 9 publications

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“…Similar expression patterns, as observed for Sox9, have been described for Nkx2.2 and Nkx6.1, which are crucial determinants of endocrine cell differentiation (Sussel et al, 1998;Sander et al, 2000). Expression of Sox9 has also been reported recently in the human pancreas (Piper et al, 2002). The main difference between our results and the study in humans is that the expression of Sox9 decreases in human islets during the second trimester.…”

Section: Resultscontrasting

confidence: 66%

“…The main difference between our results and the study in humans is that the expression of Sox9 decreases in human islets during the second trimester. Of interest, the analysis of humans with haploinsufficiency for Sox9 revealed a functional role for Sox9 in islet cell development, as evidenced by defects in islet cell morphology, as well as reduced expression of markers for mature islet cells (Piper et al, 2002).…”

Section: Resultsmentioning

confidence: 99%

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Expression of Sox transcription factors in the developing mouse pancreas

Lioubinski¹,

Müller²,

Wegner

et al. 2003

Developmental Dynamics

113

128

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Previous work has identified members of the homeodomain and basic helix-loop-helix families of transcription factors as critical determinants of mammalian pancreatic development. Here, we describe the identification of HMG-box transcription factors of the Sox gene family in the mouse pancreas. We detected transcripts for Sox11, Sox4, Sox13, Sox5, Sox9, Sox8, Sox10, Sox7, Sox17, Sox18, Sox15, and Sox30 in embryonic pancreas and found Sox4, Sox9, and Sox13 in adult pancreatic islets. Expression of seven of these Sox factors was studied in more detail by in situ hybridization from the stage of early pancreatic outgrowth to birth. Expression of Sox11 was found in the mesenchyme surrounding the pancreatic buds, whereas Sox4 and Sox9 were confined to the pancreatic epithelium and later to islets. Sox13 and L-Sox5 showed expression in most of the pancreatic epithelial cells between embryonic days 12.5 and 14.5. Sox8 and Sox10 were detected in a thin layer of cells surrounding the islets. The expression patterns of Sox genes in the embryonic pancreas suggest that they could have important and possibly redundant functions in pancreas development. Developmental Dynamics 227:402-408, 2003.

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Section: Resultscontrasting

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Expression of Sox transcription factors in the developing mouse pancreas

Lioubinski¹,

Müller²,

Wegner

et al. 2003

Developmental Dynamics

113

128

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show abstract

“…β-Catenin reactivity is diminished in endocrine structures. Scale bars, 50 μm latter have been implicated in human [22] and mouse development (Fig. 8a-c).…”

Section: Expression Of Genes For Mesenchymal Cellsmentioning

confidence: 98%

Global gene expression profiling and histochemical analysis of the developing human fetal pancreas

et al. 2007

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“…They also made links between Sox9 and the Notch effector Hes1 in maintenance of the progenitor cells. Human Sox9 haploinsufficiency causes abnormal acinar and endocrine pancreas formation (Piper et al, 2002). Studies by Lynn et al (2007) reported that Sox9 regulates the expression of a battery of TF genes in the primary pancreatic MPC such as Onecut1/HNF6, TCF2/HNF1b, and Foxa2, perhaps implicating it as one of the central coordinators of the transcriptional networks that define the pancreatic MPC condition.…”

Section: Sox9mentioning

confidence: 99%

Pancreas organogenesis: From bud to plexus to gland

Pan

Wright

2011

Developmental Dynamics

528

594

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Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a step-wise process of organ development from early bud specification all the way to the final mature organ state. Extensive research on pancreas development over the last few years, largely driven by a translational potential for pancreatic diseases (diabetes, pancreatic cancer, and so on), is markedly advancing our knowledge of these processes. It is a tenable goal that we will one day have a clear, complete picture of the transcriptional and signaling codes that control the entire organogenetic process, allowing us to apply this knowledge in a therapeutic context, by generating replacement cells in vitro, or perhaps one day to the whole organ in vivo. This review summarizes findings in the past 5 years that we feel are amongst the most significant in contributing to the deeper understanding of pancreas development. Rather than try to cover all aspects comprehensively, we have chosen to highlight interesting new concepts, and to discuss provocatively some of the more controversial findings or proposals. At the end of the review, we include a perspective section on how the whole pancreas differentiation process might be able to be unwound in a regulated fashion, or redirected, and suggest linkages to the possible reprogramming of other pancreatic cell-types in vivo, and to the optimization of the forward-directed-differentiation of human embryonic stem cells (hESC), or induced pluripotential cells (iPSC), towards mature b-cells. Developmental Dynamics 240:530-565,

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Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia

Cited by 90 publications

References 9 publications

Expression of Sox transcription factors in the developing mouse pancreas

Expression of Sox transcription factors in the developing mouse pancreas

Global gene expression profiling and histochemical analysis of the developing human fetal pancreas

Pancreas organogenesis: From bud to plexus to gland

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