Novel soybean polypeptide dglycin alleviates atherosclerosis in apolipoprotein E-deficient mice

Zhao, Han; Peng, Dan; Xi, Jiahui; Chen, Zhengwang; Zhang, Ping; Wei, Wei; Zhao, Yanying

doi:10.1016/j.ijbiomac.2023.126347

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Atherosclerosis is a condition characterized by the accumulation of a lipid layer in the arterial wall, reducing artery elasticity and narrowing the arterial lumen ( Dong et al, 2020 ). Endothelial dysfunction is a leading cause of atherosclerotic plaque and a risk factor for myocardial infarction rupture ( Zhao et al, 2023 ). Zhu and colleagues found that SeQDs can inhibit the activity of Na+/H+ exchanger 1 (NHE1) and impair calcium ion/calpain signaling, effectively improving endothelial cell relaxation, preventing endothelial dysfunction, and limiting the growth of atherosclerotic plaques ( Zhu et al, 2019 ).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

A mini review on selenium quantum dots: synthesis and biomedical applications

Huang,

Lu,

Zhou

2023

Front. Bioeng. Biotechnol.

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In recent years, the demand for advanced biomedical nanomaterials has seen a noticeable surge. Among the essential trace elements in the human body, selenium has gained recognition for its anti-cancer, antioxidant, and immune regulatory properties. However, traditional selenium-based semiconductor quantum dots (QDs) are often comprised of heavy metal elements that tend to be toxic, thereby limiting their usage in biomedical applications. Fortunately, the advent of elemental selenium quantum dots (SeQDs), a new kind of fluorescent nanomaterial with unique physicochemical properties, has provided a solution to this problem. These SeQDs are known for their low toxicity and good biocompatibility, making them a promising candidate for biomedical applications. In this mini-review, we delve into the synthesis methods of fluorescent SeQDs and the latest progress in their applications in bioimaging, biosensing, and diagnosis treatment. Finally, we identify the major challenges and future prospects in the field of SeQDs.

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Section: Biomedical Applicationsmentioning

confidence: 99%

A mini review on selenium quantum dots: synthesis and biomedical applications

Huang,

Lu,

Zhou

2023

Front. Bioeng. Biotechnol.

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The Disulfide Bond-Mediated Cyclization of Oral Peptides

Yao,

Ye,

Yang

et al. 2024

CPPS

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‘Structure determines function’ is a consensus in the current biological community, but the structural characteristics corresponding to a certain function have always been a hot field of scientific exploration. A peptide is a bio-active molecule that is between the size of an antibody and a small molecule. Still, the gastrointestinal barrier and the physicochemical properties of peptides have always limited the oral administration of peptides. Therefore, we analyze the main ways oral peptide conversion strategies of peptide modification and permeation enhancers. Based on our analysis of the structure of natural oral peptides, which can be absorbed through the gastrointestinal tract, we believe that the design strategy of natural stapled peptides based on disulfide bonds is good for oral peptide design. This cannot only be used to identify anti-gastrointestinal digestive structural proteins in nature but also provide a solid structural foundation for the construction of new oral peptide drugs.

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Deer Blood Hydrolysate Protects against D-Galactose-Induced Premature Ovarian Failure in Mice by Inhibiting Oxidative Stress and Apoptosis

Wang,

Pei,

Chen

et al. 2024

Nutrients

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Background: Premature ovarian failure (POF) is a common disease among women, which can cause many complications and seriously threaten women’s physical and mental health. Currently, hormone replacement therapy is the primary treatment for premature ovarian failure. However, the side effects are serious and will increase the chance of breast cancer and endometrial cancer. Deer blood hydrolysate (DBH) is the product of enzymatic hydrolysis of deer blood, has antioxidant, anti-ageing, and anti-fatigue effects, and has the potential to improve premature ovarian failure. Methods: In our experiment, a mouse model of premature ovarian failure was established through intraperitoneal injection of 400 mg/kg/d of D-gal for 42 days. At the same time, different doses of DBH were gavaged to observe its ameliorative effect on premature ovarian failure. Results: The experimental findings indicated that DBH could restore the irregular oestrus cycle of POF mice, improve the abnormal amounts in serum hormones follicle-stimulating hormone (FSH), luteinising hormone (LH), progesterone (P) and estradiol (E2), increase the number of primordial follicles and decrease the number of atretic follicles. In addition, DBH also raised the level of superoxide dismutase (SOD) and reduced the level of malondialdehyde (MDA) and reduced the apoptosis of ovarian granulosa cells in mice. The WB assay results showed that gavage of DBH restored the decrease in the indication of nuclear factor erythroid 2-related factor 2 (Nrf2), Heme Oxygenase-1 (Ho-1), and B-cell lymphoma-2 (Bcl-2) proteins and reduced the elevated expression of Kelch-like ECH-associated protein 1 (Keap1), Bcl-2 associated X protein (Bax), and Cysteinyl aspartate specific proteinase-3 (Caspase-3) proteins that were induced by D-gal. Conclusions: To sum up, the present research indicated that DBH can ameliorate D-gal-induced oxidative stress and apoptosis by regulating the Nrf2/HO-1 signalling pathway and the Bcl-2/Bax/caspase-3 apoptosis pathway, which can be used for further development as a nutraceutical product to improve premature ovarian failure.

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Novel soybean polypeptide dglycin alleviates atherosclerosis in apolipoprotein E-deficient mice

Cited by 3 publications

References 36 publications

A mini review on selenium quantum dots: synthesis and biomedical applications

A mini review on selenium quantum dots: synthesis and biomedical applications

The Disulfide Bond-Mediated Cyclization of Oral Peptides

Deer Blood Hydrolysate Protects against D-Galactose-Induced Premature Ovarian Failure in Mice by Inhibiting Oxidative Stress and Apoptosis

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