Novel Species of Chlamydia Isolated From Snakes are Temperature-sensitive and Exhibit Decreased Susceptibility to Azithromycin

Staub, Eveline; Marti, H. R.; Biondi, Roberta; Levi, Aurora; Donati, Manuela; Seth-Smith, Helena M. B.; Borel, Nicole

doi:10.1016/j.jcpa.2017.10.058

Cited by 5 publications

(8 citation statements)

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“…Chlamydiae are obligate intracellular bacteria that cause a variety of human and animal diseases (Rohde et al, 2010). Chlamydia (C.) serpentis, C. poikilothermis, as well as Candidati C. corallus, and C. sanzinia are newly discovered or proposed chlamydial species identified so far in captive snakes (Taylor-Brown et al, 2016, 2017Staub et al, 2018). Very little knowledge is available about their pathogenic potential.…”

Section: Short Communicationmentioning

confidence: 99%

“…From the whole genome sequence of C. serpentis (Staub et al, 2018), specific primers Serpentis_192F (5'-TGA AGA CTT AAG AGA AGA TGC GGT-3') and Serpentis_291R (5'-TGC GGG GAC TTT TAC TAG CC-3') as well as a specific probe Serpentis_251P (5'-FAM-ACG TTC CAG AGT CTT TAG GGG-TAMRA 3') were designed using the primer3 software. This specific qPCR assay was designed based on the Glutamyl-tRNA(Gln) amidotransferase subunit C (gatC) gene locus only identified so far in C. serpentis.…”

Section: Short Communicationmentioning

confidence: 99%

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A cluster of Chlamydia serpentis cases in captive snakes

Laroucau

Aaziz

Lécu³

et al. 2020

Veterinary Microbiology

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Section: Short Communicationmentioning

confidence: 99%

Section: Short Communicationmentioning

confidence: 99%

A cluster of Chlamydia serpentis cases in captive snakes

Laroucau

Aaziz

Lécu³

et al. 2020

Veterinary Microbiology

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“…Estas bacterias causan una amplia gama de enfermedades en diferentes hospederos animales y el hombre (1,2) . Dentro del género, se han reportado un total de doce especies (3) (4)(5)(6) .…”

Section: Introductionunclassified

Diagnóstico, prevención y control de enfermedades causadas por Chlamydia en pequeños rumiantes. Revisión

Aldama

Jiménez

Guerrero

2022

Rev. Mex. Cienc. Pecu.

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Las especies que conforman el género Chlamydia afectan una amplia gama de hospederos animales, causando diversas patologías. Chlamydia abortus (C. abortus), Chlamydia psittaci (C. psittaci) y Chlamydia pecorum (C. pecorum) son las de mayor relevancia clínica en pequeños rumiantes a nivel mundial, ya que han sido relacionadas con problemas reproductivos, oculares y del tracto digestivo respectivamente; dos de estas (C. abortus y C. psittaci), representan un riesgo potencial zoonótico al ser humano. El diagnóstico de infecciones por organismos de este género resulta complicado; ya que, en la mayoría de los casos no hay signología clínica que indique la presencia del agente en animales afectados. Actualmente en países europeos la prevención y control principalmente de C. abortus se realiza mediante la administración de inmunógenos atenuados comerciales; sin embargo, su uso no ha mostrado resultados satisfactorios en la protección de animales susceptibles. Por lo tanto, la implementación de nuevas opciones de inmunización basadas en la utilización de proteínas recombinantes es la línea de investigación que más realce está tomando actualmente. Adicionalmente, el uso de proteínas con potencial inmunogénico podrían ser herramientas importantes para el diagnóstico, prevención y control de estos patógenos. Debido a esto, la presente revisión se centró en recapitular los estudios más actuales enfocados al uso experimental de diferentes proteínas inmunogénicas de Chlamydia spp. empleadas a nivel mundial, destacando su innovación y resultados obtenidos en los modelos experimentales.

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“…In reptiles, chlamydiosis has been reported in both free-ranging and captive animals, with C. pneumoniae being the most frequently reported. 2,3,11–16,19,20,25–29,31,32 Chlamydia-associated lesions reported in this group of vertebrates include necrotizing to granulomatous myocarditis, hepatitis, splenitis, enteritis, conjunctivitis, and pneumonia; 3,12–15,19,26,27,32 however, C. pneumoniae and other potentially novel, poorly characterized Chlamydia species have also been identified in clinically normal snakes and turtles. 16,20,25 Recently, 2 novel Chlamydia species, Chlamydia serpentis and Chlamydia poikilothermis (most closely related to C. pneumoniae and C. psittaci , and C. caviae and C. abortus , respectively), were isolated from captive snakes.…”

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confidence: 99%

“…16,20,25 Recently, 2 novel Chlamydia species, Chlamydia serpentis and Chlamydia poikilothermis (most closely related to C. pneumoniae and C. psittaci , and C. caviae and C. abortus , respectively), were isolated from captive snakes. 28 Regarding the occurrence of chlamydiosis in members of the order Crocodilia, outbreaks have been described in different species of crocodiles. 13,14,26,32 Most recently, fulminant systemic disease was identified in an outbreak in juvenile Siamese crocodiles ( Crocodylus siamensis ) associated with a Chlamydia species closely related to C. caviae and C. psittaci.…”

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confidence: 99%

An outbreak of systemic chlamydiosis in farmed American alligators (Alligator mississippiensis)

Carossino

Nevarez

Sakaguchi³

et al. 2022

Vet Pathol

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Chlamydia spp are reported to causes systemic disease in a variety of hosts worldwide including few reports in crocodilians. Disease presentations vary from asymptomatic to fulminant disease, some of which are zoonotic. The aim of this study was to describe the pathological, immunohistochemical, and molecular findings associated with the occurrence of a previously unreported Chlamydia sp infection causing a major mortality event in farmed American alligators ( Alligator mississippiensis). The outbreak presented with sudden death in juvenile alligators mainly associated with necrotizing hepatitis and myocarditis, followed by the occurrence of conjunctivitis after the initial high mortality event. The widespread inflammatory lesions in multiple organs correlated with intralesional chlamydial organisms identified via immunohistochemistry and confirmed by 23S rRNA-specific real-time quantitative polymerase chain reaction (qPCR) for Chlamydiaceae bacteria. By sequencing and phylogenetic analysis of the OmpA gene, this uncultured Chlamydia sp grouped closely with Chlamydia poikilothermis recently described in snakes. This study highlights the significance of such outbreaks in farmed populations. Enhanced epidemiological monitoring is needed to gain further insight into the biology of Chlamydia sp in alligators, disease dynamics, risk factors, and role of carrier animals.

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Novel Species of Chlamydia Isolated From Snakes are Temperature-sensitive and Exhibit Decreased Susceptibility to Azithromycin

Cited by 5 publications

References 0 publications

A cluster of Chlamydia serpentis cases in captive snakes

A cluster of Chlamydia serpentis cases in captive snakes

Diagnóstico, prevención y control de enfermedades causadas por Chlamydia en pequeños rumiantes. Revisión

An outbreak of systemic chlamydiosis in farmed American alligators (Alligator mississippiensis)

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