Novel Spherical Trimethoprim–Niflumic Acid Drug–Drug Salt Demonstrates Simultaneous Enhancement of Powder Property and Antibacterial Activity

Zhu, Yanshan; Lin, Qiongxi; Fan, Hongying; Zhang, Li; Yang, Shiying; Yang, Dezhi; Lu, Yang; Zhou, Zhengzheng

doi:10.1021/acs.cgd.4c00562

Crystal Growth & Design

2024

DOI: 10.1021/acs.cgd.4c00562

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Novel Spherical Trimethoprim–Niflumic Acid Drug–Drug Salt Demonstrates Simultaneous Enhancement of Powder Property and Antibacterial Activity

Yanshan Zhu,

Qiongxi Lin,

Hongying Fan

et al.

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2024

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Cited by 1 publication

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Exploring Salts of Memantine with Inorganic Anions: From Polymorphism and Solid-State Transitions to Potential for Drug Formulations

Tuksar,

Topić,

Rubčić

et al. 2024

Mol. Pharmaceutics

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This study examines pharmaceutically acceptable inorganic salts of memantine, specifically focusing on hydrogen sulfate, sulfate, and dihydrogen phosphate salts, with the aim of finding alternatives to the commonly used chloride salt in the treatment of Alzheimer’s disease. Through comprehensive solid-state characterization, including powder X-ray diffraction, thermal analysis, and solubility testing, we unveil complex polymorphic behaviors, reversible solid-state transitions, and significant differences in solubility and stability among the salts. Notably, the hydrogen sulfate salt emerges as a promising candidate for drug formulations, offering improved solubility, nonhygroscopic nature, and favorable morphological characteristics compared to the existing chloride salt. This work establishes a foundation for further investigation into memantine salts as potential therapeutics with improved efficacy.

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Exploring Salts of Memantine with Inorganic Anions: From Polymorphism and Solid-State Transitions to Potential for Drug Formulations

Tuksar,

Topić,

Rubčić

et al. 2024

Mol. Pharmaceutics

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show abstract

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Novel Spherical Trimethoprim–Niflumic Acid Drug–Drug Salt Demonstrates Simultaneous Enhancement of Powder Property and Antibacterial Activity

Cited by 1 publication

References 77 publications

Exploring Salts of Memantine with Inorganic Anions: From Polymorphism and Solid-State Transitions to Potential for Drug Formulations

Exploring Salts of Memantine with Inorganic Anions: From Polymorphism and Solid-State Transitions to Potential for Drug Formulations

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