Novel stepwise approach to assess representativeness of a large multicenter observational cohort of tuberculosis patients: The example of RePORT Brazil

Arriaga, María B.; Amorim, Gustavo; Queiroz, Artur T. L.; Rodrigues, Moreno S.; Araújo-Pereira, Mariana; Nogueira, Betânia M. F.; Souza, Alexandra B.; Rocha, Michael S.; Benjamin, Aline; Moreira, Ana Paula B.; Oliveira, Jamile G. de; Figueiredo, Marina C.; Turner, Megan; Alves, Kleydson; Durovni, Betina; Silva, José Roberto Lapa e; Kritski, Afrânio Lineu; Cavalcante, Solange; Rolla, Valéria Cavalcanti; Cordeiro-Santos, Marcelo; Andrade, Bruno B.

doi:10.1016/j.ijid.2020.11.140

Cited by 30 publications

(43 citation statements)

References 14 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RePORT-Brazil includes five study sites, located in cities with high TB burden: Salvador, Manaus, and Rio de Janeiro [20]. One main objective of the consortium is to describe the clinical outcomes of TB treatment and latent Mtb infection in Brazil.…”

Section: Methodsmentioning

confidence: 99%

“…SINAN is the Brazilian National System of Notification of Diseases [23], and includes diseases that require notification in all states and municipalities of Brazil; TB is a notifiable disease. The details of SINAN have been previously described [20]. PWTB reported to SINAN are diagnosed following the criteria in the Brazilian Manual of Recommendations for Tuberculosis control [24].…”

Section: Methodsmentioning

confidence: 99%

“…We used the SINAN information from the years 2015 to 2019 to match the enrollment period of RePORT-Brazil (see ref. [20] and Figure 1B ). Of note, in 2014 the “Strategies for Care of people with Chronic diseases”, addressing comprehensive basic care for patients with TB and DM among others [25], was implemented in Brazil.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Diabetes and Prediabetes on Anti-tuberculosis Treatment Outcomes: A Multicentric Prospective Cohort Study

Arriaga

Araújo-Pereira

Barreto-Duarte

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: It is unclear whether diabetes or prediabetes drives adverse treatment outcomes and death in people with tuberculosis (PWTB). Methods: Culture-confirmed PWTB, enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort between 2015 and 2019 (n=756) were stratified based on glycemic status by baseline glycated hemoglobin levels. Unfavorable TB outcome was defined as treatment failure or modification, recurrence or death, whereas favorable outcome was cure or treatment completion. We validated the findings using data from PWTB reported to the Brazilian National System of Diseases Notification (SINAN) during 2015-2019 (n=20,989). Stepwise binary multivariable regression analysis models evaluated associations between glycemic status and unfavorable outcomes. Results: In both cohorts, in univariate analysis, unfavorable outcomes were more frequently associated with drug resistance and HIV infection. Diabetes was associated with unfavorable outcomes in the RePORT (aOR: 2.85, p=0.001) and in SINAN (aOR: 1.56, p=0.040) cohorts. Furthermore, diabetes was associated with higher risk of death in both, RePORT-Brazil (aOR:3.23, p=0.006) and in the SINAN (aOR:2.75, p= 0.047) cohorts. Conclusion: Diabetes was associated with an increased risk of unfavorable outcomes and mortality in Brazilian PWTB. Interventions to improve tuberculosis treatment outcomes in persons with diabetes are needed.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Diabetes and Prediabetes on Anti-tuberculosis Treatment Outcomes: A Multicentric Prospective Cohort Study

Arriaga

Araújo-Pereira

Barreto-Duarte

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this study, we included data from close TB contacts identified in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil [12] between TPT was recommended according to the National TB Control Program of Brazil [2,11]. TPT was also initiated based on the physician's decision to treat and RePORT-Brazil did not influence such decision.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we included data from close TB contacts identified in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil [12] between August 27 th , 2015, and July 18 th , 2019, with follow-up between 6 and 24 months. The RePORT-Brazil consortium is an ongoing, multicenter, cohort study, which follows culture-confirmed pulmonary TB cases and their close contacts.…”

Section: Methodsmentioning

confidence: 99%

Determinants of losses in the latent tuberculosis infection cascade of care in Brazil: a prospective multicenter cohort study

Souza

Arriaga

Amorim

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Factors associated with losses in the latent tuberculosis infection (LTBI) cascade of care in contacts of tuberculosis (TB) patients were investigated in a multicenter prospective cohort from highly endemic regions in Brazil. Methods: Close contacts of 1,187 culture-confirmed pulmonary TB patients were prospectively studied between 2015 and 2019, with follow-up between 6 and 24 months. Data on TB screening by clinical investigation, radiographic examination and interferon-gamma release assay (IGRA) were collected. Stepwise multivariable models were used to identify determinants of losses in the LTBI cascade. Results: Among 4,145 TB contacts initially identified, 1,901 were examined (54% loss). Within those individuals, 933 were people living with HIV, ≤5 years-old and/or had positive IGRA results, therefore having recommendation to start TB preventive treatment (TPT). Of those, 454 (23%) initiated treatment, and 247 (6% of all TB contacts) completed TPT. Multivariable regression analysis revealed that living with HIV, illiteracy, and black/pardo (brown) race were independently associated with losses in cascade. Conclusion: There were losses at all LTBI cascade stages, but particularly at the initial screening and examination steps. Close contacts who are socially vulnerable and living with HIV were at heightened risk of not completing the LTBI cascade of care in Brazil.

show abstract

Possible sex difference in latent tuberculosis infection risk among close tuberculosis contacts

Wada¹,

Costa²,

Araújo-Pereira³

et al. 2022

International Journal of Infectious Diseases

Self Cite

View full text Add to dashboard Cite

Novel stepwise approach to assess representativeness of a large multicenter observational cohort of tuberculosis patients: The example of RePORT Brazil

Cited by 30 publications

References 14 publications

The Effect of Diabetes and Prediabetes on Anti-tuberculosis Treatment Outcomes: A Multicentric Prospective Cohort Study

The Effect of Diabetes and Prediabetes on Anti-tuberculosis Treatment Outcomes: A Multicentric Prospective Cohort Study

Determinants of losses in the latent tuberculosis infection cascade of care in Brazil: a prospective multicenter cohort study

Possible sex difference in latent tuberculosis infection risk among close tuberculosis contacts

Contact Info

Product

Resources

About