2019
DOI: 10.1093/braincomms/fcz021
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Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts

Abstract: Increasing evidence for the cumulative effects of head trauma on structural integrity of the brain has emphasized the need to understand the relationship between tissue mechanic properties and injury susceptibility. Here, diffusion tensor imaging, helmet accelerometers and amplified magnetic resonance imaging were combined to gather insight about the region-specific vulnerability of the corpus callosum to microstructural changes in white-matter integrity upon exposure to sub-concussive impacts. A total of 33 m… Show more

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Cited by 24 publications
(39 citation statements)
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“…The median linear and rotational head accelerations for striking and struck players reported in this study are lower than measurements in other similar studies. 8,11,12,30,31 Four other studies have measured head impact magnitudes in Canadian university football players using the GFT head impact sensor. 8,11,12,31 However, only one of them used a location-dependent algorithm to calculate centre of mass impact magnitudes from the helmet shell measurements 8 which reduces the mean absolute percent error of peak linear and rotational accelerations measurements from 50% to less than 10%.…”
Section: Discussionmentioning
confidence: 99%
“…The median linear and rotational head accelerations for striking and struck players reported in this study are lower than measurements in other similar studies. 8,11,12,30,31 Four other studies have measured head impact magnitudes in Canadian university football players using the GFT head impact sensor. 8,11,12,31 However, only one of them used a location-dependent algorithm to calculate centre of mass impact magnitudes from the helmet shell measurements 8 which reduces the mean absolute percent error of peak linear and rotational accelerations measurements from 50% to less than 10%.…”
Section: Discussionmentioning
confidence: 99%
“…We have developed a subject-specific FE model of the human brain using their MR images. 11,31 However, the material properties for this model came from the literature, limiting its subject-specificity to the geometry and white matter fiber tracts only. Therefore, the location-specific material properties obtained from our study along with the MRI scans taken both pre and post-impact are being used to create a completely subject-specific finite element model (both geometry and material propertywise), which will be the first fully subject-specific brain FE model.…”
Section: Discussionmentioning
confidence: 99%
“…A subject-specific finite element model of the human brain was generated from magnetic resonance imaging (MRI) data of our previous research [19] where a longitudinal study with male Canadian football players was performed to measure the changes in brain structure measured with MRI. Briefly, MRI data (T1 high resolution anatomical image and diffusion tensor imaging (DTI)) from football players (all male, average age = 20.3 1.4) was acquired longitudinally over the course of the season at three time points -1) prior to the pre-season training camp within 2 months before the first contact practice ("PRE"); 2) post training following 14day training camp and the first two games of the season ("PTC"); 3) post season ("POST").…”
Section: A Subject-specific Fe Analysis Of the Brain With Embedded Wmentioning
confidence: 99%
“…The parameter values 1,~4, were obtained from Chatelin et al [19] and given below (Table 1). Other major tissues in the brain were modelled separately, which included the dura matter, falx and scalp.…”
Section: Figure 3 Embedding the White Matter Fibre Orientation To Thmentioning
confidence: 99%
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