Novel Strategies for Physical Data Fitting Based on a Cooling Crystallization Process of myo-Inositol

Abstract

Exhaustive data of myo-inositol solution at different temperatures, including the solubility, saturation ratio, refractive index, density, and viscosity, were measured in this work. Considering the cooling crystallization of myo-inositol, supersaturated solutions were used at 303.2−323.2 K, and unsaturated solutions were used at 328.2−353.2 K. To reduce the tedious data measurement process, novel data fitting strategies were proposed in this work. According to these strategies, models used to calculate the physical data and the saturation ratio were obtained by fitting. In these models, only the temperature and the refractive index, which could be quickly and accurately measured by instruments, were used as input variables. The calculated values from the new models were compared with experimental data and calculated values from empirical models. Root-mean-square deviation and average relative deviation were also used as evaluation indicators. As the results showed, in the myo-inositol−water system, models in this work were better than empirical models in most parts. The results obtained in this work are instructive for the cooling crystallization process of myo-inositol and inspiring to fitting model of physical data.

Intensive Research on the Nucleation Induction Time in Cooling Crystallization of the Myo-inositol–Water System: Data Measurement and Establishment of Prediction Models

“…Before the experiment, the laser pointer is used to illuminate the solution. If the Tyndall effect does not occur, the solution is considered to be clear. , …”

“…According to the measured solubility data from our previous work, 17 solutions of MI with different supersaturations were prepared at different temper-atures. When the supersaturated solution was prepared, the MI was fully dissolved by raising the temperature, and then the temperature was rapidly reduced to the target temperature.…”

“…If the Tyndall effect does not occur, the solution is considered to be clear. 9,21 The experiments of this work were carried out in the instrument shown in Figure 1.…”

“…In our previous study, the physical parameters of MI during cooling crystallization were measured, and convenient fitting equations were provided. 17 Since the measurement of the induction time is a timeconsuming process, calculating the induction time through predictive models will provide great convenience for industrial production. Based on classical nucleation theory, the relationship between the induction time and saturation ratio can be quantitatively studied.…”

“…MI crystals are usually obtained by cooling crystallization. , In the batch cooling crystallization, all mother liquor needs to be slowly cooled, so the process is time-consuming. At the same time, the cooling rate is difficult to accurately control, which has a significant impact on the crystallization process.…”