Novel strategies for the treatment of migraine attacks via the CGRP, serotonin, dopamine, PAC1, and NMDA receptors

Tajti, János; Csáti, Anett; Vécsei, László

doi:10.1517/17425255.2014.963554

Cited by 11 publications

(5 citation statements)

References 113 publications

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“…Thus, alteration in the activity of the rate-limiting step of the Trp-KYN metabolic system influences the serotonin pathway as well. This is suggested in the pathomechanisms of migraine, depression, and certain other psychiatric syndromes [123].…”

Section: Discussionmentioning

confidence: 98%

Memory Enhancement with Kynurenic Acid and its Mechanisms in Neurotransmission

Martos¹,

Tuka²,

Tanaka³

et al. 2022

Preprint

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Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess neuroprotective property. KYNA plays critical roles in nociception, neurodegeneration, and neuroinflammation. A lower level of KYNA is observed in patients with neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases or psychiatric disorders such as depression and autism spectrum disorders, whereas a higher level of KYNA is associated with the pathogenesis of schizophrenia. Little is known about the optimal concentration for neuroprotection and the threshold for neurotoxicity. In this study the effects of KYNA on memory functions were investigated by passive avoidance test in mice. Six different doses of KYNA were administered intracerebroventricularly to previously trained CFLP mice and they were observed following 24 hours. High doses of KYNA (i.e., 20-40 μg/2 μl) significantly decreased the avoidance latency, whereas a low dose of KYNA (0.5 μg/2 μl) significantly elevated it compared with controls, suggesting that the low dose of KYNA enhanced memory function. Furthermore, six different receptor blockers were applied to reveal the mechanisms underlying the memory enhancement induced by KYNA. The series of tests revealed the possible involvement of the serotonergic, dopaminergic, α and β adrenergic, and opiate systems in the nootropic effect. The study confirmed that a low dose of KYNA improved a memory component of cognitive domain, which was mediated by, at least in part, four systems of neurotransmission in an animal model of learning and memory.

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Section: Discussionmentioning

confidence: 98%

Memory Enhancement with Kynurenic Acid and its Mechanisms in Neurotransmission

Martos¹,

Tuka²,

Tanaka³

et al. 2022

Preprint

Self Cite

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“…On the other hand, centrally released PACAP may lead to the activation of second-order sensory neurons in the TNC in a process mediated by the PAC1 receptor, which leads to central sensitization. Both the peripheral and the central sensitization processes take part in the initiation of migraine attacks [19,184,[198][199][200][201].…”

Section: Discussionmentioning

confidence: 99%

Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects

Tajti

Delia

Nagy-Grócz

et al. 2017

CMC

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“…5-HT 1F receptors have been shown to be expressed in glutamatergic neurons of the trigeminal system and also in the cerebral vessels, with no vasoconstrictor effect [45][46]. The ability of 5-HT 1F receptors to modulate trigeminal responses without any effect on the vascular tone made 5-HT 1F agonists promising tools as innovative anti-migraine drugs [47][48]. 4-Fluoro-N-[3-(1methyl-4-piperidinyl)-1H-indol-5-yl]-benzamide (LY334370) has been shown to be a high-affinity agonist of the 5-HT 1F receptor [49].…”

Section: -Hydroxytryptamine (5-ht Serotonin)mentioning

confidence: 99%