Novel Strategy to Prevent Atrial Fibrosis and Fibrillation

Takahashi, Naohiko; Kume, Osamu; Wakisaka, Osamu; Fukunaga, Naoya; Teshima, Yasushi; Hara, Masahide; Saikawa, Tetsunori

doi:10.1253/circj.cj-12-1099

Cited by 37 publications

(24 citation statements)

References 58 publications

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“…HSP72, which was also targeted by another three lncRNAs (BC049991, AV310809, and AK080622) in the network and which plays a part in the MAPK signaling pathway, was closely related to tissue fibrosis. Takahashi reported that HSP72 can attenuate atrial fibrosis in three different experimental models of atrial fibrillation (Takahashi et al, 2012). Studies in obstructive nephropathy show that HSP72 can markedly reduce cell proliferation in the tubular epithelium, and can decrease interstitial fibroblast accumulation and collagen I deposition.…”

Section: Discussionmentioning

confidence: 99%

The expression profiling and ontology analysis of noncoding RNAs in peritoneal fibrosis induced by peritoneal dialysis fluid

Guo

Hao

et al. 2015

Gene

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Section: Discussionmentioning

confidence: 99%

The expression profiling and ontology analysis of noncoding RNAs in peritoneal fibrosis induced by peritoneal dialysis fluid

Guo

Hao

et al. 2015

Gene

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“…Higher levels of oxidative stress are known to promote inflammation, fibrosis, and apoptosis [19]. Cellular hypertrophy and fibrosis, features commonly observed in diabetic cardiomyopathy [4], are promoted by increased reactive oxygen species (ROS) production [20–23].…”

Section: Discussionmentioning

confidence: 99%

Apocynin attenuates left ventricular remodeling in diabetic rabbits

Qiu

Zhao

et al. 2017

Oncotarget

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IntroductionNicotinamide adenine dinucleotide phosphate (NADPH) oxidases are responsible for the generation of reactive oxygen species, producing vascular and myocardial dysfunction in diabetes mellitus. However, the potential benefits of the NADPH oxidase inhibitor, apocynin, on left ventricular (LV) remodeling remain unknown.ResultsIn the diabetic group, interventricular septal thickness and left ventricular posterior wall thickness were markedly increased compared to control. These changes were accompanied by increased LV cardiomyocyte cross-sectional area and greater degree of interstitial fibrosis. NO, myeloperoxidase, and malonaldehyde levels in the serum were significantly increased Moreover, protein expression levels of rac1, nuclear factor-κB, transforming growth factor-β, p38, P-p38, and metalloproteinase-9 were also raised. Apocynin treatment prevented all of these structural, histological and biochemical changes and additionally increased superoxide dismutase levels.MethodsThirty Japanese rabbits were randomized into three groups: control, alloxan-induced diabetes with and without apocynin treatment at 15 mg/kg/day for 8 weeks (n = 10 for each group). Echocardiography was performed and hemodynamics were assessed by carotid and LV catheterization. LV cardiomyocyte cross-sectional area and interstitial fibrosis were evaluated by histology. Serum nitric oxide (NO), malonaldehyde, myeloperoxidase, superoxide dismutase (SOD) levels, and activity of LV tissue NADPH oxidases was assessed. Expression of proteins involved in pro-inflammatory and pro-fibrotic signaling were determined by Western blotting.ConclusionsInhibition of NADPH oxidase using apocynin is an effective upstream therapy for preventing diabetes-induced adverse remodeling of the left ventricular myocardium.

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“…Our data were supported by other reports that found the supplement of L-arginine to ameliorate the endothelial dysfunction and thrombus formation in models of both arterial and venous thrombosis. 46,47 Hydroxymethylglutaryl (HMG)-CoA reductase inhibitors and omega-3 fatty acids, which are known to improve endothelial dysfunction, show the protective effect in animal models of AF, 48 but the results, which these have the effectiveness or not, remain controversial in AF patients. 49,50 Therefore, it is still unknown which therapies focused on endothelial dysfunction alone, and which therapies were used that were similar to this study that could recover LA thrombosis completely in AF patients.…”

Section: Discussionmentioning

confidence: 99%