Novel structural features increase the antioxidant effect of estrogen analogues on low density lipoprotein

Fidarov, A F; Vihma, Veera; Bogautdinov, Roman P.; Морозкина, С. Н.; Шавва, А. Г.; Tikkanen, Matti J.

doi:10.1016/j.jsbmb.2015.08.001

Cited by 4 publications

(4 citation statements)

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“…Physical and biochemical disorders occurring in aging women are strongly related to the failure in ovarian function, especially to the deficiency in estrogen production (Chappell, 2007). Added to its reproductive role, this specific hormone is indispensable in the regulation of fat distribution and in preventing oxidative damage in the body's cells (Fidarov et al, 2015; Renaville, Piasentier, Bacciu, & Prandi, 2012). This accounts for the higher risk of obesity and kidney dysfunction, associated usually with post‐menopausal status.…”

Section: Resultsmentioning

confidence: 99%

Protective effects of Avena sativa against oxidative stress‐induced kidney damage resulting from an estrogen deficiency in ovariectomized Swiss mice model

et al. 2020

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The aim of this study was to evaluate the antioxidant capacity of Avena sativa and to confirm its protective effects on estrogen deficiency in ovariectomized mice (OVX) model. Animals were treated during 21 and 60 days as follows: negative control, positive control treated with oat, ovariectomized, and ovariectomized receiving hormonal or oat treatments, respectively. 21 days post‐surgery, our results showed that ovariectomy increases weight gain and urea level in plasma. After 60 days of treatment, OVX showed a gain in weight, high increases in relative kidney weight, plasmatic creatinine, glutathione peroxidase (GPX) activity, and protein oxidation as shown by elevated protein carbonyl (PCO) and advanced oxidation protein products (AOPP) levels. On the other side, a decrease was detected in catalase activity. Meanwhile, no significant changes in urea level, lipid peroxidation, SOD and GSH activity were detected. Conversely, supplementation with oat reduced weight gain, as well as oxidative stress and oxidation protein in the kidney of OVX mice. Practical applications In our study, we removed the two ovaries of adult female mice in order to eliminate the essential source of steroid hormones. Deficiency in these sexual hormones, especially estrogen, leads to several physiological and morphological disturbances that are found in post‐menopausal women. The gain in weight and oxidative kidney damages were the main health problems detected in ovariectomized animals. This work explored for the first time the use of oat grains as a safe natural remedy to treat all previous health problems and to avoid carcinogenic effects of the menopausal hormone therapy. Owing to its health benefits, this cereal species has recently gained attention as an important source of antioxidants and fibers. Thanks to these two components, it can be able to restore all indicated disturbances. Therefore, this cereal can be very useful in the prevention of obesity and kidney oxidative damage occurring during menopause.

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Section: Resultsmentioning

confidence: 99%

Protective effects of Avena sativa against oxidative stress‐induced kidney damage resulting from an estrogen deficiency in ovariectomized Swiss mice model

et al. 2020

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“…Numerous studies have shown that 17- is a powerful antioxidant (Kumar et al 2011;Fidarov et al 2015;El-Gendy et al 2019). In the present study, a significant decrease was observed in the oxidative parameters of the 17--treated groups.…”

Section: Gsh and Gsh Px Results In Kidney And Liver Cellsmentioning

confidence: 99%

“…It has been reported that free radical production and apoptotic pathways are regulated by the treatments of 17-β, TAM, and RAL (Yang et al 2004;Moreira et al 2005;Konyalioglu et al 2007;Moreira et al 2007;Moreira et al 2011;Yazğan and Nazıroğlu, 2017). Numerous studies have shown that estrogen is a powerful antioxidant (Kumar et al 2011;Fidarov et al 2015;Yazğan and Nazıroğlu, 2017;Gendy et al 2019;Ltaif et al 2020;Xu et al 2020). Recent studies documented that RAL has antioxidant properties in vitro (Arteaga et al 2003;Mann et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of tamoxifen and raloxifene on apoptosis and oxidative stress in the kidney and liver of ovariectomized rats

Yazğan

2020

Journal of Cellular Neuroscience and Oxidative Stress

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Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease.Areas of particular interest are four topics. They are;A-Ion Channels (Na + -K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

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“…As expected, we observed higher Phe reactivity and lower ACh reactivity in the mesenteric vessels in the l -NAME-treated groups, with even more pronounced effects in ovariectomized animals (LOAD group). This was mainly attributable to the antioxidant effects of estradiol, which exerts protective effects on endothelial function even in the absence of NO [43]. Although these results show an increase in cardiovascular risk factors in the LOAD group, these changes do not specifically reflect atherosclerotic lesions.…”

Section: Discussionmentioning

confidence: 98%

Development of a Predictive Model to Induce Atherogenesis and Hepato-Renal Impairment in Female Rats

et al. 2019

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Therapeutic approaches for the treatment of dyslipidemia and atherosclerosis have radically changed in recent decades. Part of this advance undeniably stems from basic biomedical research that has provided a better understanding and identification of new therapeutic targets. The aim of this work was to develop a model to induce atherogenesis and hepato-renal impairment in female Wistar rats. The following groups received the respective treatments for 60 days: control animals, non-ovariectomized rats that received an atherogenic diet (NEAD), ovariectomized rats that received an atherogenic diet (NOAD), non-ovariectomized rats that received an atherogenic diet and oral Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME; LEAD), and ovariectomized rats that received an atherogenic diet and oral l-NAME (LOAD). Animals in the NEAD, NOAD, LEAD, and LOAD groups also received methimazole and cholecalciferol daily. Urinary, biochemical, hemodynamic, and electrocardiographic parameters and renal function were assessed. Samples of the liver, heart, kidney, and arteries were collected to investigate redox status and perform histopathological analyses. All of the groups developed dyslipidemia and hepatic steatosis. Only the NEAD group developed arterial lesions that were compatible with fatty streaks. Renal function was significantly impaired in the LEAD and NOAD groups. These results indicate a viable alternative to induce atherogenesis and hepato-renal impairment in female rats.

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Novel structural features increase the antioxidant effect of estrogen analogues on low density lipoprotein

Cited by 4 publications

References 34 publications

Protective effects of Avena sativa against oxidative stress‐induced kidney damage resulting from an estrogen deficiency in ovariectomized Swiss mice model

Protective effects of Avena sativa against oxidative stress‐induced kidney damage resulting from an estrogen deficiency in ovariectomized Swiss mice model

Protective effects of tamoxifen and raloxifene on apoptosis and oxidative stress in the kidney and liver of ovariectomized rats

Development of a Predictive Model to Induce Atherogenesis and Hepato-Renal Impairment in Female Rats

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