Novel Synergistic Catalysis by Ethylcarbodiimide Hydrochloride Salt and CuI Towards Morita‐Baylis‐Hillman Reaction

Abstract

Scheme 1. Salt-catalysed synthesis of MBH adduct. Scheme 2. EDC.HCl/CuI-promoted unprecedented synthesis of MBH adduct.

Recent progress and prospects in the organocatalytic Morita–Baylis–Hillman reaction

“…The MBH reaction between various aldehydes and methyl acrylate or acrylonitrile has been previously described. 56 In this methodology, efficient and environmentally benign ethylcarbodiimide (EDC) hydrochloride salt was employed as a catalyst at room temperature ( Scheme 39 ). Benzaldehydes with electron-donating substituents were well tolerated in this reaction.…”