Nano-scale plastic debris (NPDs) are emerging as potential contaminants as they can be easily ingested by aquatic organisms and carry many pollutants in the environment. This study is aimed to remove NPDs from aqueous environment for the first time by using eco-friendly adsorption techniques. Initially, the interaction between NPDs and synthesized Zn-Al layered double hydroxide (LDH) was confirmed by pH titration of Zn-Al LDH against NPDs at varying mass ratio (50:1 to 50:7) and FTIR analysis for both before and after 2 h of contact time. Fast removal was observed in deionized water and synthetic freshwater with maximum sorption capacity (Q max ) of 164.49 mg/g,162.62 mg/g, respectively, according to Sips isotherm. Whereas, removal was least in synthetic hard water having a Q max value of 53 mg/g. For 2 mM concentration of SO 4 2− and PO 4 3-, the adsorption capacity significantly decreased to 2%. The removal efficiency was found 100 % at pH 4, while at pH 9,