2017
DOI: 10.3390/molecules22101712
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Novel Synthesis of Core-Shell Silica Nanoparticles for the Capture of Low Molecular Weight Proteins and Peptides

Abstract: Silica nanoparticles were functionalized with immobilized molecular bait, Cibacron Blue, and a porous polymeric bis-acrylamide shell. These nanoparticles represent a new alternative to capture low molecular weight (LMW) proteins/peptides, that might be potential biomarkers. Functionalized core-shell silica nanoparticles (FCSNP) presented a size distribution of 243.9 ± 11.6 nm and an estimated surface charge of −38.1 ± 0.9 mV. The successful attachment of compounds at every stage of synthesis was evidenced by A… Show more

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Cited by 11 publications
(15 citation statements)
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“…This behaviour may be attributed to the hydrophilic nature of the organic compound attached to the core of nanoparticles, which form a dense layer that increases electrostatic repulsion at the surface and, therefore, increases particle size. 16,26 Finally, due to growth of the polymer chains 27,28 in shell formation, nanoparticles reached 479.6 AE 6.9 nm in size.…”
Section: Synthesis and Characterization Of Nanoparticlesmentioning
confidence: 99%
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“…This behaviour may be attributed to the hydrophilic nature of the organic compound attached to the core of nanoparticles, which form a dense layer that increases electrostatic repulsion at the surface and, therefore, increases particle size. 16,26 Finally, due to growth of the polymer chains 27,28 in shell formation, nanoparticles reached 479.6 AE 6.9 nm in size.…”
Section: Synthesis and Characterization Of Nanoparticlesmentioning
confidence: 99%
“…1(1). 16,31 In Fig. 1(2), new absorption peaks appeared at 1628 cm À1 , which correspond to C]C stretching vibrations 32 and another peak at around 1701 cm À1 associated to C]O groups of the monomer.…”
Section: Synthesis and Characterization Of Nanoparticlesmentioning
confidence: 99%
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