Novel synthesis of fluorescent carbon dots from bio-based Carica Papaya Leaves: Optical and structural properties with antioxidant and anti-inflammatory activities

Gudimella, Krishna Kanthi; Gedda, Gangaraju; Kumar, Praveen; Babu, B.; Yamajala, K. Durga Bhaskar; Rao, B. Dharma; Singh, Prabal Pratap; Kumar, Deepak; Sharma, Ajit

doi:10.1016/j.envres.2021.111854

Cited by 62 publications

(36 citation statements)

References 32 publications

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“…Using CompuSyn software, data analysis for free radical scavenging activity and dose-response studies were performed to assess the potency of the selected herbs. A lower EC 50 indicates greater radical scavenging activity [ 28 ]. SPSS software was used for statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

et al. 2022

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Natural antioxidants derived from plants have been proven to have significant inhibitory effects on the free radicals of living organisms during actively metabolization. Excessive production of free radicals increases the risk of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and motor sclerosis. This study aimed to compare the ethnopharmacological effects of Urtica dioica (UD), Matricaria chamomilla (MC), and Murraya koenigii (MK) on the amelioration of rotenone-induced toxicity in wild-type Drosophila melanogaster (Oregon R+) at biochemical, cellular, and behavioral levels. Phytoextracts were prepared from all three plants, i.e., UD, MC, and MK (aqueous and ethanolic fractions), and their bioactive compounds were evaluated using in vitro biochemical parameters (DPPH, ABTS, TPC, and TFC), UV-Vis, followed by FT-IR and HPLC. Third instar larvae and freshly eclosed flies were treated with 500 µM rotenone alone or in combination with UD, MC, and MK for 24 to 120 h. Following exposure, cytotoxicity (dye exclusion test), biochemical (protein estimation and acetylcholinesterase inhibition assays), and behavioral assays (climbing and jumping assays) were performed. Among all three plant extracts, MK exhibited the highest antioxidant properties due to the highest TPC, TFC, DPPH, and ABTS, followed by UD, then MC. The overall trend was MK > UD > MC. In this context, ethnopharmacological properties mimic the same effect in Drosophila, exhibiting significantly (p < 0.05) reduced cytotoxicity (trypan blue), improved biochemical parameters (proteotoxicity and AChE activity), and better behavioral parameters in the organisms cotreated with phyto extracts compared with rotenone. Conclusively, UV-Vis, FTIR, and HPLC analyses differentiated the plant extracts. The findings of this research may be beneficial in the use of select herbs as viable sources of phyto-ingredients that could be of interest in nutraceutical development and various clinical applications.

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Section: Methodsmentioning

confidence: 99%

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

et al. 2022

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“…Flavonoids are secondary metabolites that significantly contribute to wound healing activity (Soib et al, 2020). These components can act as an antiinflammatory, antimicrobial and antioxidant (Gudimella et al, 2022) which are needed in the wound healing process. Therefore, papaya leaves can be used in herbal-based medicine and as a potential source for drug formulations (Ayoola, Adeyeye, and State, 2010).…”

Section: Resultsmentioning

confidence: 99%

Potential Benefit of Flavonoid in Papaya Leave Gel in Neutrophil, Angiogenesis, and Wound size in Rattus Norvegicus

et al. 2022

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An incision wound is the destruction of several cells in the skin area that has experienced an incision. Several factors influencing wound healing are neutrophils as causative agents of inflammation, angiogenesis, and wound closure. These three factors should undergo physiologically to obtain the optimal healing process. Currently, herbal products are preferred because they have lower side effects than synthetic ones. Papaya leaves contain flavonoids with various functions, including wound closure and anti-inflammatory and antioxidant effects. Topical intervention, especially gel, is good for healing because it can keep the wound moist. This research aimed to determine the effect of the administration of papaya leaf gel on wound closure, neutrophil, and angiogenesis. Thirty white rats were used as the model animals in a randomized experimental study divided into five groups comprising negative control (0,9% NaCl), positive control (10% Povidone-iodine), and three intervention groups treated with gel of Carica papaya leaves at a dosage 10%, 20%, and 30%. All groups were topically administered treatment once a day on the dorsal surface for seven days. Carica papaya leaves contain flavonoids, saponin, tannin, and alkaloids qualitatively and 7,734 mg/kg of the flavonoid quantitatively. There were no significant differences in wound size in all three groups on three days, but Carica papaya leave gel had a superior effect compared to 10% PI and 0,9% NaCl in the wound closure process. There were significant differences in all groups in neutrophil and angiogenesis. Nevertheless, 20% papaya leave gel showed the lowest number of neutrophils and had a superior effect on improving the new blood vessels significantly compared to negative and positive groups.

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“…RESUMEN: El propósito de la presente investigación fue analizar las potencialidades de las semillas de Carica papaya Linn y aceite para su aprovechamiento como factor determinante en la salud. Por lo cual, se realizó una revisión bibliográfica exhaustiva con enfoque cualitativo de tipo descriptivo, documentados en estudios científicos de autores como Gudimella et al, (2022); Gnanamangai et al, (2022); Rao et al, (2022); Pereira et al, (2021); Nandini et al, (2021); Agada et al, (2020); Hafid et al, (2020); Ávila et al, (2020), Morais et al, (2017); Sharma et al, (2016); entre otros. Las semillas presentaron alto contenido de proteínas, carbohidratos, lípidos, fibra, minerales, fitoquímicos que incluyen antioxidantes los cuales brindan un alto valor nutricional beneficiando la salud de poblaciones desnutridas.…”

Section: Apresentaçãounclassified

“…ABSTRACT: The purpose of this research was to analyze the potential of Carica papaya Linn seeds and oil for their use as a determining factor in health. Therefore, an exhaustive bibliographic review was carried out with a descriptive qualitative approach, documented in scientific studies by authors such as Gudimella et al, (2022); Gnanamangai et al, (2022); Rao et al, (2022); Pereira et al, (2021); Nandini et al, (2021); Agada et al, (2020); Hafid et al, (2020); Ávila et al, (2020), Morais et al, (2017); Sharma et al, (2016); among others. The seeds presented a high content of proteins, carbohydrates, lipids, fiber, minerals, phytochemicals that include antioxidants, which provide a high nutritional value, benefiting the health of undernourished populations.…”

Section: Apresentaçãomentioning

confidence: 99%

“…La Carica papaya Linn contiene grandes cantidades de compuestos bioactivos y de valor nutracéutico, lo que proporciona beneficios potenciales para la salud (Nwofia et al, 2012), es de gran utilidad en el tratamiento de muchas enfermedades (estreñimiento, amenorrea, cáncer, prevención de úlceras), por lo cual es considerada una fruta con propiedades funcionales (Krishna et al, 2008 Numerosos estudios han reportado que todas las partes del árbol Carica papaya Linn; hojas, frutos, semillas, látex, cortezas tallos y flores son ricas en componentes bioactivos por lo que se utilizan en diversos tratamientos de enfermedades, tales como: la presión arterial, cáncer, diabetes, malaria y dengue; en la medicina tradicional son utilizadas en tratamientos para el agrandamiento del hígado, el bazo, las pecas y el crecimiento canceroso (Gnanamangai et al, 2022;Gudimella et al, 2022;Pereira et al, 2021).…”

Section: Introductionunclassified

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CONTRIBUCIÓN POTENCIAL DE LAS SEMILLAS DE Carica papaya Linn Y SU ACEITE EN LA SALUD

Arrieta¹,

Mendoza²,

Zapa³

2022

Agrárias: Pesquisa E Inovação Nas Ciências Que Alimentam O Mundo VIII

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O conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons Atribuição-Não-Comercial NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). Direitos para esta edição cedidos à Editora Artemis pelos autores. Permitido o download da obra e o compartilhamento, desde que sejam atribuídos créditos aos autores, e sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.A responsabilidade pelo conteúdo dos artigos e seus dados, em sua forma, correção e confiabilidade é exclusiva dos autores. A Editora Artemis, em seu compromisso de manter e aperfeiçoar a qualidade e confiabilidade dos trabalhos que publica, conduz a avaliação cega pelos pares de todos manuscritos publicados, com base em critérios de neutralidade e imparcialidade acadêmica.

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Novel synthesis of fluorescent carbon dots from bio-based Carica Papaya Leaves: Optical and structural properties with antioxidant and anti-inflammatory activities

Cited by 62 publications

References 32 publications

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

Ethnopharmacological Effects of Urtica dioica, Matricaria chamomilla, and Murraya koenigii on Rotenone-Exposed D. melanogaster: An Attenuation of Cellular, Biochemical, and Organismal Markers

Potential Benefit of Flavonoid in Papaya Leave Gel in Neutrophil, Angiogenesis, and Wound size in Rattus Norvegicus

CONTRIBUCIÓN POTENCIAL DE LAS SEMILLAS DE Carica papaya Linn Y SU ACEITE EN LA SALUD

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