Novel synthesis of isoquinolin-3-ols

Abstract

Reaction of phenacetyl chlorides with alkyl or DERIVATIVES of isoquinolin-3-01 have previously been prearyl thiocyanates in the presence of a Friedel-Crafts pared by the cyclisation of o-acylphenylacetic acids with catalyst yieIds 1-substituted-isoquinolin-3-01s.ammonia or amines,l the acid-catalysed cyclisation of