Novel synthesis, spectral characterisation and DFT calculation of (3,4-bis((E)-(substituted-dichlorobenzylidene)amino) phenyl) (phenyl) methanone derivatives

Enbaraj, E.; Dhineshkumar, E.; Jeyashri, K.R.; Logeshwari, G.; Mohana, V.; Manikandan, H.; Rajathi, V.; Chakkaravarthy, J.; Seenivasan, M.

doi:10.1016/j.matpr.2020.11.978

Cited by 3 publications

(2 citation statements)

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“…3), and this capacity was consistent with those to those of BHA and BHT (Table 1) that are employed as standard drugs. The lower concentrations of the tested samples were more potent in quenching ABTS + free radicals in the system [37]. The three series of Schiff bases exhibit powerful scavenging of the ABTS + radical relative to those of the standards (BHA and BHT).…”

Section: Abts Radical Scavenging Activitymentioning

confidence: 89%

“…The results of the ABTS radical test by the Schiff bases were shown to be much better than those of DPPH•. Many factors like solubility of the compounds' stereoselectivity of the radicals or the indifferent testing systems have been conveyed to affect the aptitude of compounds to react and inhibit different radicals [37][38]. Hong et al [39] observed that some compounds that present ABTS scavenging response did not display DPPH scavenging ability.…”

Section: Abts Radical Scavenging Activitymentioning

confidence: 99%

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Effect of Bridging Atom and Hydroxyl Position on the Antioxidant Capacity of Six Phenolic Schiff Bases

et al. 2022

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A series of new phenolic Schiff bases N,N-bis(2,3-dihydroxybenzyl-idene)-4,4’-diphenylmethane (3-DPM), and N,N-bis(2,5-dihydroxybenzylidene)-4,4’-diphenylmethane (5-DPM), for sulfide bridge N,N-bis(2,3-dihydroxybenzyl-idene)-4,4’-diphenyl sulfide (3-DPS), N,N-bis(2,5-dihydroxybenzylidene)-4,4’-diphenyl sulfide (5-DPS), N,N-bis(2,3-dihydroxybenzyl-idene)-4,4’-diphenyl disulfide (3-DPSS), and N,N-bis(2,5-dihydroxybenzylidene)-4,4’-diphenyl disulfide (5-DPSS) were synthesized by condensation of substituted 4,4’-diamino-bis-(4-aminophenyl) methane/sulfide with various substituted aldehydes. The synthesized molecules were characterized by physical data, elemental, IR and 1H-NMR analyses. The antioxidant ability of compounds was determined through the use in vitro assays such as DPPH• scavenging, ABTS, total antioxidant capacity (TAC), hydroxyl radical OH• scavenging, and reducing power capability. The antioxidant activity of the compounds increased slightly after changing the atom bridge and hydroxyl group position. The results showed that the compound 5-DPSS exhibited superior scavenging strength against DPPH (EC50 = 7.10 ± 0.16 μg/mL), whereas 3-DPSS showed the highest activity (EC50 = 1.36 ± 0.08 μg/mL) when inspected by ABTS in relation to butylated hydroxyanisole (BHA) (EC50 = 7.54 ± 0.67). The higher OH• activity was marked by the compound 5-DPS (EC50 = 44.9 ± 3.3 μg/mL) related to BHT at (EC50 = 98.73 ± 0.3 μg/mL). The compounds 5-DPM demonstrated remarkable activity both reducing power (EC50 = 53.2 ± 0.3 μg/mL), and TAC assay (EC50 = 620.0 ± 2.4 μg/mL). These results prove that the modification in hydroxyl group position affect the antioxidant ability of Schiff bases.

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Section: Abts Radical Scavenging Activitymentioning

confidence: 89%