Novel synthetic analogue of ACTH 4–10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia

The Effect of ACTH4-10 synthetic on separated junction formation and CSF leukocyte number in LPS-induced meningitis

“…Until now, many researches try to find new therapeutics to control excessive inflammatory response caused by bacterial products 3,8 . Analog ACTH 4-10 (ACTH [4][5][6][7] Pro-Gly-Pro) synthetic is the agent nootropik, a group of neuropeptides and acts as an endogenous neuromodulator function of the CNS 9 (Bashkatova et al, 2001). From previous studies it was found that Analog ACTH 4-10 synthetic had angioprotective, neurothrophic, antihypoxic effects on neuroinflammatory diseases 10 .…”

“…The Effect Of ACTH [4][5][6][7][8][9][10] The purpose of this study was to evaluate the effect of ACTH 4-10 synthetic after LPS exposure through the number of leukocytes in the CSS and change separated junction between cerebral microvascular endothelial cells.…”

“…ACTH [4][5][6][7][8][9][10] synthetic is a product of PT SEMAX axomedica developed by the Institute of Molecular Genetics, Russian Academy of Science Moscow, Russia and Lomonosov University in Moscow, with the concentration 0,1%. Based on the previous study, the used doses 1 drop for each nostril.…”

“…The Effect Of ACTH [4][5][6][7][8][9][10] Synthetic On Separated Junction Formation And CSF Leukocyte Number In The number of leukocyte in CSF Cerebrospinal fluid sample collected by intracisternal puncture was performed to determine the number of leukocyte in normal rats of control and the experimental groups. This study showed the significant increase of leucocytes number in the control group when compared with the normal rats and after administration of ACTH4-10 synthetic, the number of leukocyte was nearly normal ( Table 2).…”

“…The Effect Of ACTH [4][5][6][7][8][9][10] Synthetic On Separated Junction Formation And CSF Leukocyte Number In homeostasis that should be able to restrict the influx of the cells, hormones, enzymes, bacteria and the others from blood into the brain 15 . Separated junction causes leukocyte influx into CSS.…”