Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications

Green Conditions for Passerini Three-Component Synthesis of Tocopherol Analogues

“…Atherosclerosis and its cardiovascular complications constitute the major cause of morbidity and mortality in developing countries. , An estimated 17.3 million people died from cardiovascular diseases (CVDs) in 2008, and it is expected that by 2030 more than 23 million people will die annually from CVDs. Epidemiological studies suggested that antioxidant supplementation might prevent the development of atherosclerotic lesions . Recently, hybrid molecules combining vitamin E substructures (tocopherol analogues) and nitric oxide ( · NO)-releasing moieties (furoxans and organic nitrates) have been developed, and promising results in vitro were obtained. − In this context, our group is interested on the development of nitric oxide-releasing tocopherol analogues with structural diversity, which is highly desirable and valuable for medicinal chemistry and drug candidate discovery.…”