Novel systemic inflammation response index to predict prognosis after thoracoscopic lung cancer surgery: a propensity score‐matching study

Abstract

Background Our propensity score‐matching (PSM) study evaluated the prognostic significance of systemic inflammation response index (SIRI) for patients undergoing video‐assisted thoracoscopic surgery lobectomy for non‐small‐cell lung cancer (NSCLC). Methods This study was conducted on prospectively maintained database in our institution between December 2013 and March 2015. Pre‐operative SIRI was calculated by peripheral monocyte × neutrophil/lymphocyte counts. Survival analysis was performed to distinguish differences in post‐operative survival between patients stratified by an optimum cut‐off of SIRI. Multivariable Cox proportional hazards regression models were established to determine independent prognostic factors. Results There were 390 patients with resected NSCLC included. A SIRI of 0.99 was identified as the optimum cut‐off regarding to post‐operative survival. Both overall survival (OS) and disease‐free survival (DFS) in patients with SIRI >0.99 were significantly shortened than those in patient with SIRI ≤0.99. Patients with SIRI >0.99 had significantly lower rates of OS and DFS compared to those patients with SIRI ≤0.99. These differences still remained significant after subgroup analyses and PSM analyses. Multivariable analyses on the entire cohort and the PSM cohort commonly demonstrated that high pre‐operative SIRI could be an independent prognostic factor for unfavourable OS and DFS of NSCLC. Conclusions SIRI serves as a novel risk stratification tool to refine prognostic prediction for surgically resected NSCLC. SIRI may help surgeons to screen high‐surgical‐risk patients and formulate individualized treatment schemes.

Evidence of the Prognostic Value of Pretreatment Systemic Inflammation Response Index in Cancer Patients: A Pooled Analysis of 19 Cohort Studies

“…And for NPC and AEG [ 17 , 22 ], the AUC value was higher for SIRI compared with the NLR, PLR, and MLR at both the 3- and 5-year follow-up. SIRI also achieved the largest AUCs compared with those of NLR, PLR, and lymphocyte-to-monocyte ratio (LMR) and was the only significant discriminator for OS and DFS in the propensity score matching cohort in NSCLC [ 21 ]. Besides, SIRI could more accurately predict OS of ESCC patients compared with the TNM staging system in the nomogram [ 18 ].…”

Clinical Significance of Systemic Inflammation Response Index and Platelet–lymphocyte Ratio in Patients with Adenocarcinoma of The Esophagogastric Junction and Upper Gastric Cancer

“…Hu et al [31] found that high-sensitivity C-reactive protein in non-obese radiotherapy patients with malignant tumors could predict grade 4 skin toxicity, and advise doctors to change treatment options. Recently, the prognostic importance of SIRI for patients with renal, pancreatic and nasopharyngeal cancers has been con rmed [25,[32][33][34][35][36]. The higher the SIRI score is, the shorter the disease-free survival and OS.…”

Prognostic Significance of Preoperative Serum Uric Acid to Lymphocyte Ratio in Advanced Gastric Cancer A Propensity Score-Matched Analysis

“…To reduce the impact of confounding factors, we formulated a propensity score matching (PSM) model by the nearest neighbor method with a 0.2 caliper width and 1:1 ratio propensity score matching. In the PSM model, the components of the ULR could not participate in the matching [ 14] , which indicated that the serum markers from routine blood and biochemical tests were not taken into account in the PS balance.…”