2015
DOI: 10.2147/rru.s56168
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Novel targeted bladder drug-delivery systems: a review

Abstract: The objective of pharmaceutics is the development of drugs with increased efficacy and reduced side effects. Prolonged exposure of the diseased tissue to the drug is of crucial importance. Drug-delivery systems (DDSs) have been introduced to control rate, time, and place of release. Drugs can easily reach the bladder through a catheter, while systemically administered agents may undergo extensive metabolism. Continuous urine filling and subsequent washout hinder intravesical drug delivery (IDD). Moreover, the … Show more

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Cited by 50 publications
(62 citation statements)
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“…The most common dysfunctions are bladder cancer, interstitial cystis (IC), bladder pain syndrome, and overactive bladder (OAB). Recent comprehensive reviews on novel drug delivery systems for bladder dysfunction therapy have been recently been published …”
Section: Application Specific Requirementmentioning
confidence: 99%
“…The most common dysfunctions are bladder cancer, interstitial cystis (IC), bladder pain syndrome, and overactive bladder (OAB). Recent comprehensive reviews on novel drug delivery systems for bladder dysfunction therapy have been recently been published …”
Section: Application Specific Requirementmentioning
confidence: 99%
“…Other routes of administration applicable to medications for UTIs are reviewed in Ref. 48. For wound infections, direct delivery to the wound is the preferred option, reviewed in Ref.…”
Section: Discussionmentioning
confidence: 99%
“…Likely, other conditions manifested by mucosal injury, such as interstitial cystitis, or cyclophosphamide(24) and irradiation(25) induced cystitis can also benefit from the proposed targeting approach. Indeed, in view of increased interest in effective delivery of supramolecular carriers and hydrogels to the bladder pathologies, (26, 27) the use of CPP-coupled nano- and microcarriers could offers exciting possibilities in management of acute and chronic disease of bladder mucosa. The focal catheter injury is used to mimic the pathological conditions wherein the mucosa is injured.…”
Section: Discussionmentioning
confidence: 99%