Novel temperature/pH-responsive hydrogels based on succinoglycan/poly(N-isopropylacrylamide) with improved mechanical and swelling properties

Hu, Yan‐Yan; Kim, Young S.; Jeong, Jaepil; Park, Sohyun; Shin, Younghyun; Hong, In Ki; Kim, Moo Sung; Jung, Seunho

doi:10.1016/j.eurpolymj.2022.111308

Cited by 20 publications

(10 citation statements)

References 60 publications

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“…This may be attributed to the fact that the charged particles, UV radiation, and the increase in gas temperature within the discharge chamber (Figure S5, Supporting Information), which can modify the composition, structure, or surface functionality of the gels, resulting in a weakened buffering effect. [53,54] In Figure 2b, the ORP increase of DW after the plasma treatment is also higher than that of these three gels, and the ORP of D-PAHs is much higher than that of I-PAHs, which is also consistent with the pH change, i.e., the lower the pH value, the higher the ORP in the PAH system. Therefore, PAH has achieved a buffering response of pH and ORP under plasma activation, and we expect to discussing other properties of PAH in the next section.…”

Section: Physicochemical Properties Of Pahsupporting

confidence: 62%

Plasma‐Activated Hydrogels for Microbial Disinfection

et al. 2023

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A continuous risk from microbial infections poses a major environmental and public health challenge. As an emerging strategy for inhibiting bacterial infections, plasma‐activated water (PAW) has proved to be highly effective, environmental‐friendly, and non‐drug resistant to a broad range of microorganisms. However, the relatively short lifetime of reactive oxygen and nitrogen species (RONS) and the high spreadability of liquid PAW inevitably limit its real‐life applications. In this study, plasma‐activated hydrogel (PAH) is developed to act as reactive species carrier that allow good storage and controlled slow‐release of RONS to achieve long‐term antibacterial effects. Three hydrogel materials, including hydroxyethyl cellulose (HEC), carbomer 940 (Carbomer), and acryloyldimethylammonium taurate/VP copolymer (AVC) are selected, and their antibacterial performances under different plasma activation conditions are investigated. It is shown that the composition of the gels plays the key role in determining their biochemical functions after the plasma activation. The antimicrobial performance of AVC is much better than that of PAW and the other two hydrogels, along with the excellent stability to maintain the antimicrobial activity for more than 14 days. The revealed mechanism of the antibacterial ability of the PAH identifies the unique combination of short‐lived species (1O2, ∙OH, ONOO− and O2−) stored in hydrogels. Overall, this study demonstrates the efficacy and reveals the mechanisms of the PAH as an effective and long‐term disinfectant capable of delivering and preserving antibacterial chemistries for biomedical applications.

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Section: Physicochemical Properties Of Pahsupporting

confidence: 62%

Plasma‐Activated Hydrogels for Microbial Disinfection

et al. 2023

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“…Double-network hydrogels induced a larger Δ T of the skin model than the Δ T of the skin model after being contacted with single-network hydrogels (Δ T > 2.8 °C for DN gel_1 and Δ T > 3.5 °C for DN gel_2) because of the slow release of water from double-network hydrogels and the re-swelling process (see Figure S10c,d). When the temperature is above the VPTT of PNIPAM-based hydrogels, water is rapidly released from PNIPAM-based hydrogels (∼37–60% of their swelling capacity), − causing a dense entanglement of the network chains. Thus, we attribute the reduction of the hydrogel’s cooling performance in the next cycles of cooling to this phenomenon.…”

Section: Resultsmentioning

confidence: 99%

Temperature-Responsive Double-Network Cooling Hydrogels

Boon-in

Theerasilp

Crespy

2023

ACS Appl. Polym. Mater.

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Skin inflammation can occur due to the immune response of the body, infections, and injuries and lead to an increase of skin temperature. Cooling inflamed skin can relieve pain and efficiently dissipate heat. Evaporative cooling hydrogels are hence promising materials for preparing flexible dressings for cooling inflamed skin because of the high latent heat of water vaporization (∼2450 J·g–1 at 100 °C and 1 atm). We fabricate here a double-network hydrogel formed with poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS) and poly(N-isopropylacrylamide) (PNIPAM). Water can be released by the PNIPAM network above ∼32 °C, which is close to human’s skin temperature, and provides heat dissipation and cooling through evaporation. The network formed with PAMPS delays the release of water from the hydrogels. Large and prolonged cooling performance of a skin model and enhanced mechanical properties are obtained with the proposed design. Compared to other reported hydrogels for passive cooling, our material demonstrates a superior cooling power with lower temperature. This design of the hydrogel can be adapted for cooling other structures such as photovoltaic panels or roofs of buildings.

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“…The degradation curve is presented in Figure S5, PNIPAM- co -GMA-CYS hydrogels degrade much more rapidly than PNIPAM- co -GMA. PNIPAM- co -GMA-CYS absorbed more water, leading to fast hydrolysis …”

Section: Resultsmentioning

confidence: 99%

“…PNIPAM-co-GMA-CYS absorbed more water, leading to fast hydrolysis. 37 In Vitro Release. Hydrogels have high water absorption, swelling, and degradation ability, can greatly increase the deployment rate of drugs, and help to control the drug release.…”

Section: Effect Of Inhibitors On M Tuberculosismentioning

confidence: 99%

Bone-Adhesive Hydrogel for Effective Inhibition of M. tuberculosis and Osteoblast Regeneration

Mehnath,

Sathish Kumar,

Chitra

et al. 2023

ACS Infect. Dis.

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Currently, bone tuberculosis (TB) treatment largely involves lifelong drug prescriptions and surgical intervention, resulting in poor quality of life for patients. Therefore, the fabrication of injectable scaffolds to form a solid framework around the defective bone region is gaining importance over the extensive use of antimicrobial inhibitors. Herein, we synthesized a novel bone-adhesive and thermoresponsive hydrogel via conjugation of poly(N-isopropylacrylamide-co-glycidyl methacrylate) (PNIPAM-co-GMA) and cysteine (CYS). Thiolation of the polymer enables chemical cross-linking with the bone glycoprotein, enhancing bone adhesion and permitting control of scaffold retention time. The PNIPAM-co-GMA-CYS hydrogel shows higher cross-linking behavior at 37 °C, forms a strong gel in 260 s, and has 151 kPa adhesion strength on cortical bone. The lead compounds 5-methyl-5H-[1,2,4]triazino[5,6-b]indole-3-thiol (MTIT) and N-tert-butyl-4-methyl-6-(5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)pyrimidin-2-amine (TMTIPA) were identified by a high-throughput screening method. Effective MTIT and TMTIPA are encapsulated in bone-adhesive hydrogel separately, and both have a high release rate above >70% in 180 h. The MTIT- and TMTIPA-loaded PNIPAM-co-GMA-CYS showed an excellent bactericidal effect, reducing the relative intracellular bacterial survival in macrophages. Furthermore, the as-synthesized hydrogel has outstanding mechanical and biocompatibility properties to become a bone-replacing material and provide support to promote bone repair. This work presents a novel bone-adhesive PNIPAM-co-GMA-CYS for the sustained release of lead compounds toward promising alternative bone TB treatment.

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Novel temperature/pH-responsive hydrogels based on succinoglycan/poly(N-isopropylacrylamide) with improved mechanical and swelling properties

Cited by 20 publications

References 60 publications

Plasma‐Activated Hydrogels for Microbial Disinfection

Plasma‐Activated Hydrogels for Microbial Disinfection

Temperature-Responsive Double-Network Cooling Hydrogels

Bone-Adhesive Hydrogel for Effective Inhibition of M. tuberculosis and Osteoblast Regeneration

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