Novel Therapeutic Approaches for Neuroblastoma

Joshi, Shweta; Singh, Alok R.; Hartman, Lisa L.R.; Zulcic, Hyunah Ahn Muamera; Durden, Donald L.

doi:10.5772/55451

Cited by 2 publications

(2 citation statements)

References 149 publications

(164 reference statements)

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“…He used to go to the field with the flock of goats and sheep while he was of 6/7 years" (Sarbahari, 2059, p.19). Joshi (2075) has presented the issue of Kamaiya and Kamalari in his novel Sakhi. It has portrayed the miseries of Kamaiya and Kamalari in western Terai.…”

Section: Delineation Of Slavery In Literaturementioning

confidence: 99%

Delineation of Slavery in Selected Literature of Nepal

2023

Haimaprabha

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Slavery stands as the cultural practice, norms and values where one class entice, persuade and force another class to assist, work and Labor for the benefits of the former. It was a common practice in the world when people were not aware about their rights. Empowerment of people resulted the end of slavery in most of the countries. Slavery was eradicated from Nepal in 1981 B. S. by Rana Prime minister Chandra Shumsher Rana. It was just a legal declaration but it was a great challenge to end it practically. There were different types of slavery in the society. Kamaiya, Kamalari, Haruwa, Charuwa and Haliya traditions were prevalent in different parts of Nepal. This article explores the illustration of slavery in some selected literature of Nepal. This study analyses about how slavery is presented in the literature.

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Section: Delineation Of Slavery In Literaturementioning

confidence: 99%

Delineation of Slavery in Selected Literature of Nepal

2023

Haimaprabha

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“…Various signaling pathways, including PTEN/PI3K/AKT and RAF/MEK/ERK control stabilization of MYCN and are major mediators of uncontrolled tumor growth, angiogenesis, invasion, apoptosis and cellular metabolism in neuroblastoma [19][20][21]. PI3K/AKT signaling axis controls GSK3β dependent regulation of MYCN and stabilization of HIF1α and hence the efficacy of inhibitors targeting these signaling axes has been tested in NB models [22][23][24]. Seeger and his group have extensively studied non-MYCN amplified tumors and have provided valuable information on the TME of these tumors [25][26][27].…”

Section: Genetic Alterations and Tumor Microenvironment Of Neuroblastomamentioning

confidence: 99%

Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions

Joshi

2020

Cancers

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Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the neural crest and accounts for more than 15% of all the childhood deaths from cancer. The neuroblastoma cancer research has long been focused on the role of MYCN oncogene amplification and the contribution of other genetic alterations in the progression of this malignancy. However, it is now widely accepted that, not only tumor cells, but the components of tumor microenvironment (TME), including extracellular matrix, stromal cells and immune cells, also contribute to tumor progression in neuroblastoma. The complexity of different components of tumor stroma and their resemblance with surrounding normal tissues pose huge challenges for therapies targeting tumor microenvironment in NB. Hence, the detailed understanding of the composition of the TME of NB is crucial to improve existing and future potential immunotherapeutic approaches against this childhood cancer. In this review article, I will discuss different components of the TME of NB and the recent advances in the strategies, which are used to target the tumor microenvironment in neuroblastoma.

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Novel Therapeutic Approaches for Neuroblastoma

Cited by 2 publications

References 149 publications

Delineation of Slavery in Selected Literature of Nepal

Delineation of Slavery in Selected Literature of Nepal

Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions

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