Novel Therapeutic Modality Employing Apitherapy for Controlling of Multiple Sclerosis

Hegazı, Ahmed G.; Al-Menabbawy, Khaled; Rahman, Eman H Abd El; Helal, Suzette I.

doi:10.4172/2155-9899.1000299

Cited by 11 publications

(15 citation statements)

References 37 publications

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“…Table 1 shows the therapeutic effect of bee pollen and propolis, and it can be easily noticed that bee pollen and propolis have anti-inflammatory effects, manifesting as remarkable decreases in IFN-γ, IL-1α, Il-6, VEGF, and TNF-α and a significant increase in IL-10, an anti-inflammatory cytokine. These findings are consistent with those in one previous study by Hegazi [25], which indicates that bee pollen and propolis contain active substances in the floral origin of honey bee and plants, and these active substances can act upon both innate and adaptive immune responses. These compounds decrease pro-inflammatory cytokine synthesis and superoxide anion production in rabbit neutrophils.…”

Section: Discussionsupporting

confidence: 93%

Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism

Aabed¹,

Bhat²,

Al-Dbass³

et al. 2019

Lipids Health Dis

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BackgroundNeuroinflammation plays a major role in the pathogenesis of autism because the cytokine levels are typically disturbed in the brain in autistic patients. Prebiotics-rich diet maintains the healthy gut microbiota and hence can regulate the neuroinflammation indirectly. The study aimed to investigate the role of bee pollen and propolis in ameliorating neuroinflammation, including cytokine levels, in an animal model of autism.MethodsHamsters were classified as four groups: Group I, control; Group II, autistic model/animals treated with 250 mg propionic acid (PPA)/kg body weight (BW)/day for 3 days; Group III, animals treated with bee pollen at a dose of 250 mg/kg BW/day for 4 weeks; and Group IV, animals treated with propolis at a dose of 250 mg/kg BW/day for 4 weeks. Neuroinflammatory responses were evaluated using the levels of interferon γ (IFN-γ), interleukin 1 alpha (IL-1α), IL-6, IL-10, IL-12 (p70), vascular endothelial growth factor (VEGF), and tumor necrosis factor α (TNFα).ResultsSignificant decrease of IL-10 (P<0.026), VEGF (P<0.005), and TNFα(P<0.005) levels and increased IL-1α (P<0.032), IL-6(P<0.028), and IFN-γ (P<0.013) levels were observed between the four studied groups. The neurotoxic effects of PPA was clearly presented as much higher IL-6, as pro-inflammatory cytokine (P<0.05), concomitant with much lower IL-10, as anti-inflammatory cytokine(P<0.015) compared to controls. Both bee pollen and propolis were effective in ameliorating the neurotoxic effects of PPA demonstrating non-significant changes of IL-6 and IL-10 when compared to control healthy hamsters.ConclusionsOur findings indicate that both bee pollen and propolis protect against neuroinflammation in the rodent model of autism. However, further studies are needed to investigate the clinical benefits of prebiotics-rich diet in neurodevelopmental disorders, such as autism.

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Section: Discussionsupporting

confidence: 93%

Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism

Aabed¹,

Bhat²,

Al-Dbass³

et al. 2019

Lipids Health Dis

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“…9 Bee venom therapy is the part of apitherapy that uses bee venom (BV) in the treatment of health problems. 10 However, BV is a complex mixture of a variety of proteins and peptides, some of which have strong immunogenic 11 and neurotoxic properties. 12 It was stated that BV therapy is used for treatment of many different autoimmune disorders including rheumatoid arthritis, 13 lupus, scleroderma, and multiple sclerosis.…”

Section: Introductionmentioning

confidence: 99%

“…12 It was stated that BV therapy is used for treatment of many different autoimmune disorders including rheumatoid arthritis, 13 lupus, scleroderma, and multiple sclerosis. 10 BV is a mixture of varying concentrations of proteins, polypeptides, and low-molecular-weight aromatic and aliphatic constituents. It also contains several important enzymes, that is, phospholipase A, hyaluronidase, acid phosphatase, and D-glucosidase, which are highly antigenic.…”

Section: Introductionmentioning

confidence: 99%

Role of Bee Venom and Melittin on Restraining Angiogenesis and Metastasis in γ-Irradiated Solid Ehrlich Carcinoma-Bearing Mice

et al. 2020

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Pathological angiogenesis and apoptosis evasion are common hallmarks of cancer. The present work was an endeavor to evaluate the influence of bee venom (BV) or its major constituent melittin (MEL) as antiapoptotic and angiogenic regulator modifier on the tumor growth and the cell sensitivity to ionizing radiation targeting the improvement of cancer therapeutic protocols. BV (0.56 mg/kg/day) and MEL (500 µg/kg body weight/day) were injected intraperitoneally to mice bearing 1 cm3 solid tumor of Ehrlich ascites carcinoma (EAC) for 21 consecutive days. Mice were whole-body exposed to 1 Gray (Gy) of γ-radiation (2 fractionated doses). Treatment with BV or MEL markedly suppresses the proliferation of tumor in EAC mice. The concentrations of m-RNA for angiogenic factors (TNF-α, VEGF) as well as MMPs 2 and 9 activities and NO concentration were significantly decreased, combined with improvements in apoptotic regulators (caspase-3 activity) and normal cells redox tone (catalase and free radicals content) compared with EAC mice. Moreover, the histopathological investigation confirms the improvement exerted by BV or MEL in the EAC mice group or EAC + R group. Exposure to γ-radiation sustained the modulatory effect of BV on tumor when compared with EAC + BV mice. Convincingly, the role of BV or MEL as a natural antiangiogenic in the biological sequelae after radiation exposure is verified. Hence, BV and its major constituent MEL might represent a potential therapeutic strategy for increasing the radiation response of solid tumors.

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“…Also, BVA is utilized for the treatment of acute ankle sprain, osteoarthritis, shoulder pain, post-stroke, low back pain and lumbar disc herniation . BVA involves injecting of purified and diluted bee venom into acupoints (Baek et al, 2006 andHegazi, 2012). BVA exhibits many pharmacological actions including anti-cancer, anti-arthritic anti-inflammatory and analgesic effects .…”

Section: * Corresponding Author Cell Phone +201 001mentioning

confidence: 99%

“…BVA exhibits many pharmacological actions including anti-cancer, anti-arthritic anti-inflammatory and analgesic effects . Most claims of apitherapy have not been proved to the scientific standards of evidence-based medicine and are anecdotal in nature (Hegazi, 2012). Thus, the main objective of this study was to evaluate the therapeutic effect of BVA as a complementary modality for controlling of CLBP.…”

Section: * Corresponding Author Cell Phone +201 001mentioning

confidence: 99%

Role of bee Venom Acupuncture in improving pain and life quality in Egyptian Chronic Low Back Pain patients

2017

J App Pharm Sci

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Chronic non-specific low back pain is considered to be the commonest medical symptom for which patients seek complementary and alternative medical treatment, including bee venom acupuncture. This study was done to detect the effect of bee venom acupuncture (BVA) for controlling of chronic low back pain (CLBP). We compared the effects of BVA on 40 patients with CLBP, pre-and post-treatment. The age of patient ranged from 38 to 65 with history of back pain more than 6 months. The curative effect was measured by scoring of visual analog scale (VAS), Oswestry Disability Index (ODI), serum levels TNFα, IL1β, IL-6, and NF-KB as well as ESR before and after BVA treatment. The obtained results revealed that the application of BVA ameliorated the disturbances induced by CLBP, as it showed a significant improvement in VAS (65%) accompanied with a significant improvement in ODI (75.6%) in all patients. Moreover, BVA treatment resulted in a significant (p<0.05) amelioration in serum level of TNFα (-14%), IL1β (-52%), IL-6 (-53%) and NFKB (-32.6%) and ESR (-39.8%). From the mentioned findings, it could be concluded that BVA performed an improvement in CLBP patients, regarding pain intensity, disability and quality of life supported with improvement in serum levels of TNFα, IL1β, IL-6 and NF-кB and ESR.

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Novel Therapeutic Modality Employing Apitherapy for Controlling of Multiple Sclerosis

Cited by 11 publications

References 37 publications

Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism

Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism

Role of Bee Venom and Melittin on Restraining Angiogenesis and Metastasis in γ-Irradiated Solid Ehrlich Carcinoma-Bearing Mice

Role of bee Venom Acupuncture in improving pain and life quality in Egyptian Chronic Low Back Pain patients

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