Novel therapeutic strategies for treating<i>Pseudomonas aeruginosa</i>infection

Shao, Xiaolong; Xie, Yingpeng; Zhang, Yingchao; Liu, Jingui; Ding, Yiqing; Wu, Min; Wang, Xin; Deng, Xin

doi:10.1080/17460441.2020.1803274

Cited by 41 publications

(24 citation statements)

References 397 publications

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“…The high rate of morbidity and mortality associated with P. aureginosa infections and the development of multi-drug resistance strains [ 78 ] are worldwide healthcare issues that have spurred intense research efforts aimed at the identification of new and more effective therapeutic approaches [ 79 , 80 ]. In this regard, the formation of biofilms , which enhances the ability of P. aureginosa to resist to antibiotics and to develop infection in harsh media, and the carbohydrate composition of the pathogen surface components (i.e., LPS antigens) offered new opportunities for the identification of therapeutic alternatives to antibiotics.…”

Section: Bacterial Microbes Expressing Saccharide Antigens For Nanosymentioning

confidence: 99%

Glyconanoparticles as tools to prevent antimicrobial resistance

et al. 2021

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The increased phenomenon of antimicrobial resistance and the slow pace of development of new antibiotics are at the base of a global health concern regarding microbial infections. Antibiotic resistance kills an estimated 700,000 people each year worldwide, and this number is expected to increase dramatically if efforts are not made to develop new drugs or alternative containment strategies. Increased vaccination coverage, improved sanitation or sustained implementation of infection control measures are among the possible areas of action. Indeed, vaccination is one of the most effective tools of preventing infections. Starting from 1970s polysaccharide-based vaccines against Meningococcus, Pneumococcus and Haemophilus influenzae type b have been licensed, and provided effective protection for population. However, the development of safe and effective vaccines for infectious diseases with broad coverage remains a major challenge in global public health. In this scenario, nanosystems are receiving attention as alternative delivery systems to improve vaccine efficacy and immunogenicity. In this report, we provide an overview of current applications of glyconanomaterials as alternative platforms in the development of new vaccine candidates. In particular, we will focus on nanoparticle platforms, used to induce the activation of the immune system through the multivalent-displacement of saccharide antigens. Graphical abstract

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Section: Bacterial Microbes Expressing Saccharide Antigens For Nanosymentioning

confidence: 99%

Glyconanoparticles as tools to prevent antimicrobial resistance

et al. 2021

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“…P. aeruginosa is a well-known Gram-negative opportunistic bacterial pathogen, which has posed serious threats to patients with cystic fibrosis or immunodeficiency, as well as intubated patients. Recently, in P. aeruginosa infection treatment, more and more studies have been focused on the anti-virulence factors and anti-biofilm formation [ 8 , 15 , 32 , 33 ]. In terms of inhibiting P. aeruginosa PAO1 at the given concentration of 1 mM, all tested CDPs expressed inhibition over the production of QS-regulated virulence factors, biofilm formation, and adhesion, moderately, without affecting the bacterial growth.…”

Section: Discussionmentioning

confidence: 99%

Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides

Wang

Zheng

et al. 2022

Marine Drugs

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Quorum sensing (QS) can regulate the pathogenicity of bacteria and the production of some virulence factors. It is a promising target for screening to find anti-virulence agents in the coming post-antibiotics era. Cyclo (L-Trp-L-Ser), one variety of cyclic dipeptides (CDPs), isolated from a marine bacterium Rheinheimera aquimaris, exhibited anti-QS activity against Chromobacterium violaceum CV026 and Pseudomonas aeruginosa PAO1. Unlike the CDPs composed of phenylalanine or tyrosine, the anti-QS activity has been widely studied; however, Cyclo (L-Trp-L-Ser) and derivatives, containing one tryptophan unit and one non-aromatic amino acid, have not been systematically explored. Herein, the cyclo (L-Trp-L-Ser) and seven derivatives were synthesized and evaluated. All tryptophane-contained CDPs were able to decrease the production of violacein in C. violaceum CV026 and predicted as binding within the same pocket of receptor protein CviR, but in lower binding energy compared with the natural ligand C6HSL. As for P. aeruginosa PAO1, owning more complicated QS systems, these CDPs also exhibited inhibitory effects on pyocyanin production, swimming motility, biofilm formation, and adhesion. These investigations suggested a promising way to keep the tryptophan untouched but made modifications on the non-aromatic unit to increase the anti-QS activity and decrease the cytotoxicity, thus developing a novel CDP-based anti-virulence agent.

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“…Several of these systems have been targeted for the development of antivirulents, but only the type II and type III secretion systems will be focused on in this review. A comprehensive recent review covered additional systems and drug discovery methods that are not discussed here (89).…”

Section: Toxin Secretion Systemsmentioning

confidence: 99%

High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents

Kang

Zhang

Kirienko

2021

mBio

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Antimicrobial resistance is a serious medical threat, particularly given the decreasing rate of discovery of new treatments. Although attempts to find new treatments continue, it has become clear that merely discovering new antimicrobials, even if they are new classes, will be insufficient. It is essential that new strategies be aggressively pursued. Toward that end, the search for treatments that can mitigate bacterial virulence and tilt the balance of host-pathogen interactions in favor of the host has become increasingly popular. In this review, we will discuss recent progress in this field, with a special focus on synthetic small molecule antivirulents that have been identified from high-throughput screens and on treatments that are effective against the opportunistic human pathogen Pseudomonas aeruginosa.

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Novel therapeutic strategies for treatingPseudomonas aeruginosainfection

Cited by 41 publications

References 397 publications

Glyconanoparticles as tools to prevent antimicrobial resistance

Glyconanoparticles as tools to prevent antimicrobial resistance

Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides

High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents

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