Novel therapeutic strategy in the treatment of ossification of the ligamentum flavum associated with dural ossification

Pan, Qiangqiang; Zhu, Yanyu; Zhang, Zhenhui; Mei, Wei; Wang, Qingde

doi:10.1007/s00586-023-07549-z

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…First described as a clinical condition in the 1920s, 33 OLF has since been reported as an important cause of thoracic spinal myelopathy. [34][35][36][37] Reports focused on OLF are increasing outside of East Asia as reported case numbers continue to climb. 38,39 Some reports have indicated that a range of factors including genetics, metabolic abnormalities, inflammation, and mechanical stress contribute to TOLF incidence and progression.…”

Section: Discussionmentioning

confidence: 99%

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Safety and Efficacy Outcomes Following Spinal Endoscopic Procedures for Thoracic Ligamentous Ossification

Ye,

Guo,

et al. 2023

Spine

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Study Design. Systematic review and meta-analysis. Objective. This study systematically reviewed and evaluated the safety and efficacy of spinal endoscopic techniques as a treatment for thoracic ligamentum flavum ossification (TOLF). Summary of Background Data. The use of spinal endoscopic techniques for the treatment of TOLF has increased in recent years. The present study is the first comprehensive systematic review and meta-analysis focused on the use of spinal endoscopic techniques for TOLF. Methods. The Cochrane Central, PubMed, Web of Science, and Embase databases were systematically searched for studies focused on patients undergoing spinal endoscopic techniques to treat symptomatic TOLF. Results. This meta-analysis included 23 studies. We included 323 patients (177 males, 146 females) with a mean age of 58.40±10.06 years, with 304 total recorded lesion locations of which 245 were located in the lower thoracic spine. Complications affected 35/323 patients, and the mean operative duration for 305 patients was 108.15±47.34 minutes. For 187 patients, the mean operative bleeding was 25.13±12.54 mL, while for 87 patients the mean duration of hospitalization was 4.59±1.93 days. At last follow-up，functional assessment was performed for 260 patients, of whom 200 were in excellent condition, visual analog scale (VAS) scores were assessed for 160 patients, with a mean improvement of 4.40 (3.95,4.86) Japanese Orthopedic Association (JOA) scores were recorded for 115 patients, with a mean improvement of 2.99 (2.77,3.22) , and modified Japanese Orthopedic Association (mJOA) scores were recorded for 208 patients, with a mean improvement of 3.41 (3.17,3.64) . Conclusions. These results support several advantages of spinal endoscopic techniques for the treatment of symptomatic TOLF. These include low complication rates, rapid postoperative recovery, and good functional recovery when used for single-segment, non-nodular ossification and no combined dural ossification.

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Section: Discussionmentioning

confidence: 99%

“…First described as a clinical condition in the 1920s, 33 OLF has since been reported as an important cause of thoracic spinal myelopathy 34–37 . Reports focused on OLF are increasing outside of East Asia as reported case numbers continue to climb 38,39 .…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy Outcomes Following Spinal Endoscopic Procedures for Thoracic Ligamentous Ossification

Ye,

Guo,

et al. 2023

Spine

View full text Add to dashboard Cite

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Open posterior approach versus endoscopic approach for thoracic ligamentum flavum ossification: a systematic review and meta-analysis

Lin,

Tsai,

et al. 2024

Eur Spine J

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Novel therapeutic strategy in the treatment of ossification of the ligamentum flavum associated with dural ossification

Cited by 2 publications

References 30 publications

Safety and Efficacy Outcomes Following Spinal Endoscopic Procedures for Thoracic Ligamentous Ossification

Safety and Efficacy Outcomes Following Spinal Endoscopic Procedures for Thoracic Ligamentous Ossification

Open posterior approach versus endoscopic approach for thoracic ligamentum flavum ossification: a systematic review and meta-analysis

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