Novel therapies leading to a new landscape in gynecologic tumors

Madariaga, Ainhoa; Coleman, Robert L.; González-Martín, Antonio

doi:10.1136/ijgc-2023-004318

Cited by 4 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From 1987 to 2014, the cases of EC increased by 75% globally and the mortalities associated with EC increased by 300% ( 2 , 3 ). For patients without distant metastasis, surgery is usually followed by post-operative adjuvant therapy ( 4 ). Hormone therapy may be used to protect patients with well-differentiated EC who wish to reproduce ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…For patients without distant metastasis, surgery is usually followed by post-operative adjuvant therapy ( 4 ). Hormone therapy may be used to protect patients with well-differentiated EC who wish to reproduce ( 4 ). At present, there are few effective anticancer drugs for EC; thus, it is urgent to develop novel molecular targeted drugs for EC ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

ZAP70 interaction with 13 mRNAs as a potential immunotherapeutic target for endometrial cancer

Zhang

2023

Oncol Lett

View full text Add to dashboard Cite

For advanced, refractory endometrial cancer (EC), it is advisable to find effective immunotherapeutic targets. In the present study, genes affecting the immune status of uterine corpus endometrial carcinoma (UCEC) samples within The Cancer Genome Atlas were explored by weighted correlation network analysis and differential gene expression analysis. The protein function and immune correlation of 14 key genes, including ζ-chain-associated protein kinase 70 (ZAP70), were analyzed. Based on the expression levels of key genes, the patients with UCEC were divided into two groups using consensus clustering, low expression (group 1) and high expression (group 2). Next, the functions of differentially expressed genes (DEGs) between the two groups were identified using Gene Ontology enrichment analysis, Kyoto Encyclopedia of Genes and Genomes analysis and Gene Set Enrichment Analysis. The immune status of the patients in the two groups was evaluated using immune infiltration score and the expression levels of targets of immune checkpoint inhibitors. The role of ZAP70 in the prognosis of patients with UCEC and the differences in ZAP70 expression between EC tissues and healthy intimal tissues were determined by reverse transcription-quantitative PCR and immunohistochemistry. The present study found strong correlations between key genes, including ZAP70,

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ZAP70 interaction with 13 mRNAs as a potential immunotherapeutic target for endometrial cancer

Zhang

2023

Oncol Lett

View full text Add to dashboard Cite

show abstract

Gynecological cancer tumor Microenvironment: Unveiling cellular complexity and therapeutic potential

Garg,

Ramisetty,

Raghu Subbalakshmi

et al. 2024

Biochemical Pharmacology

View full text Add to dashboard Cite

The Effect of Quercetin on the Prevention and Treatment of Gynecologic Cancer

Biyabani,

Mazidimoradi,

Ghorbani

et al. 2024

Clin. Exp. Obstet. Gynecol.

View full text Add to dashboard Cite

Objective: This review summarizes the molecular properties, anticancer effects, and bioavailability of quercetin (Que). We discussed its role in preventing and treating gynecologic cancers, assisting in the treatment of drug-resistant cases, and synergizing with other treatments. This review includes an analysis of Que’s impact on breast, ovarian, and cervical cancer. Mechanism: Gynecologic cancers are a significant cause of cancer-related deaths, leading to low survival rates and a high burden on patients and healthcare systems. They are regarded as a major health problem in women. The use of complementary therapies, such as Que, can contribute to improving patient outcomes and the quality of life. The utilization of medicinal plants as complementary and alternative medicine (CAM) is on the rise worldwide, offering new approaches to cancer treatment. This approach may provide potential treatments for various cancers, including female cancers such as breast, ovarian, and cervical cancer, either alone or in combination with other medications. Findings in Brief: Among various natural compounds, Que is commonly used as an anti-cancer supplement due to its antioxidant and anti-inflammatory properties. Que is effective in preventing and treating female cancers in a dose- and time-dependent manner, as demonstrated by numerous in vitro and in vivo studies and experiments. However, more clinical studies are required to establish this flavonoid as a therapeutic agent or as part of a drug combination in humans. Conclusions: Que helps prevent and treat gynecological cancers, reduce drug resistance, and increase the effectiveness of chemical drugs and radiotherapy. It achieves this through its anti-inflammatory, pro-oxidative, anti-proliferative, induction of apoptosis, and cell cycle arrest mechanisms. However, more human studies are needed to accurately determine of the mechanisms of action and the extent of its effectiveness.

show abstract

Novel therapies leading to a new landscape in gynecologic tumors

Cited by 4 publications

References 10 publications

ZAP70 interaction with 13 mRNAs as a potential immunotherapeutic target for endometrial cancer

ZAP70 interaction with 13 mRNAs as a potential immunotherapeutic target for endometrial cancer

Gynecological cancer tumor Microenvironment: Unveiling cellular complexity and therapeutic potential

The Effect of Quercetin on the Prevention and Treatment of Gynecologic Cancer

Contact Info

Product

Resources

About