Novel Thermally Sensitive pH-dependent Chitosan/ Carboxymethyl Cellulose Hydrogels

Chen, Huangqin; Fan, Mingwen

doi:10.1177/0883911507085070

Cited by 81 publications

(9 citation statements)

References 24 publications

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“…Additional natural and/or synthetic polymers might be combined with cellulose to obtain composite hydrogels with specific properties [30,31]. Physical, thermoreversible gels are usually prepared from water solutions of methylcellulose and/or hydroxypropyl methylcellulose (in a concentration of 1-10% by weight) [32].…”

Section: Cellulose and Cellulose-based Hydrogelsmentioning

confidence: 99%

Biodegradable Cellulose-based Hydrogels: Design and Applications

2009

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Hydrogels are macromolecular networks able to absorb and release water solutions in a reversible manner, in response to specific environmental stimuli. Such stimuli-sensitive behaviour makes hydrogels appealing for the design of ‘smart’ devices, applicable in a variety of technological fields. In particular, in cases where either ecological or biocompatibility issues are concerned, the biodegradability of the hydrogel network, together with the control of the degradation rate, may provide additional value to the developed device. This review surveys the design and the applications of cellulose-based hydrogels, which are extensively investigated due to the large availability of cellulose in nature, the intrinsic degradability of cellulose and the smart behaviour displayed by some cellulose derivatives.

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Section: Cellulose and Cellulose-based Hydrogelsmentioning

confidence: 99%

Biodegradable Cellulose-based Hydrogels: Design and Applications

2009

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“…Blending was also investigated with cellulose using other natural and synthetic polymers to provide thermo-sensitivity. Alginate salts and chitosan displayed thermo-responsive properties when blended to cellulose, however, chitosan-carboxymethyl cellulose (CMC) hydrogel displayed both thermo-sensitive and pH responsive behavior [76]. An alginate/ hydroxypropyl methyl cellulose (HPMC) copolymeric hydrogel was also investigated, displaying a controlled release rate of 400 h, using a prototype heparin drug [77].…”

Section: Polymers Employed For the Synthesis Of Stimuli-responsivementioning

confidence: 99%

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering

et al. 2016

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Biodegradable, stimuli-responsive polymers are essential platforms in the field of drug delivery and injectable biomaterials for application of bone tissue engineering. Various thermo-responsive hydrogels display water-based homogenous properties to encapsulate, manipulate and transfer its contents to the surrounding tissue, in the least invasive manner. The success of bioengineered injectable tissue modified delivery systems depends significantly on their chemical, physical and biological properties. Irrespective of shape and defect geometry, injectable therapy has an unparalleled advantage in which intricate therapy sites can be effortlessly targeted with minimally invasive procedures. Using material testing, it was found that properties of stimuli-responsive hydrogel systems enhance cellular responses and cell distribution at any site prior to the transitional phase leading to gelation. The substantially hydrated nature allows significant simulation of the extracellular matrix (ECM), due to its similar structural properties. Significant current research strategies have been identified and reported to date by various institutions, with particular attention to thermo-responsive hydrogel delivery systems, and their pertinent focus for bone tissue engineering. Research on future perspective studies which have been proposed for evaluation, have also been reported in this review, directing considerable attention to the modification of delivering natural and synthetic polymers, to improve their biocompatibility and mechanical properties.

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“…Carboxymethyl cellulose is an important ingredient in the preparation of biodegradable and biocompatible polymers that has applications in drug delivery and tissue engineering [16]. In addition to proper biocompatibility, the ability to make chemical changes in these molecules is an interesting range of ejaculations based on cellulose, which can be created from gel to porous sponge according to the type of application and type of crosslinking [17,18].…”

Section: Introductionmentioning

confidence: 99%

Construction and Evaluation of Composite Scaffold Properties of Cellulose Base Enhanced with Calcium Alginate Containing Propolis for Use in Skin Tissue Engineering

Asri

Asefnejad

Naeimi

2020

Journal of Asian Scientific Research

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Ideal wound dressing materials should meet the requirements including maintaining a local moist environment, good surface absorbance for wound exudate, decreasing wound surface necrosis, and avoiding the lack of moisture in the wound. Common treatments for infections caused by skin diseases, resulting in extensive damage and often cause the death of people. In this project, the electrolytic solution of carboxymethylcellulose / calcium alginate / propolis was used to fabricate suitable fiber diameter and uniform distribution. Cellulose is suitable for the grafting of a myriad of chemical groups because of the ample availability of hydroxyl groups, and Propolis was selected in this research due to its excellent properties, such as accelerating wound healing and cell growth and antibacterial growth. The optimum electrospinning conditions were achieved at a voltage of 20 kV, with a spacing of 20 cm from the syringe to the collecting plate and a rate of 15 ml / h. Then, to evaluate the properties of the scaffold. Scanning electron microscopy (SEM), infrared Fourier transform (FTIR), mean of weight loss were performed. Finally, for testing the cellular survival of the samples MTT test was performed and a mechanical test was performed on the specimens. The scaffold degradation rate was linear and resulted in its complete destruction in 21 days. Cytotoxicity testing of scaffolds yielded acceptable results. A suitable structure for porosity and permeability was obtained in calcium carboxymethylcellulose/calcium alginate/propolis scaffold and this scaffold is a good candidate for application in skin tissue engineering. Contribution/ Originality: In this project, the electrolytic solution of carboxymethylcellulose / calcium alginate / propolis was used to fabricate suitable fiber diameter and uniform distribution.

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Novel Thermally Sensitive pH-dependent Chitosan/ Carboxymethyl Cellulose Hydrogels

Cited by 81 publications

References 24 publications

Biodegradable Cellulose-based Hydrogels: Design and Applications

Biodegradable Cellulose-based Hydrogels: Design and Applications

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering

Construction and Evaluation of Composite Scaffold Properties of Cellulose Base Enhanced with Calcium Alginate Containing Propolis for Use in Skin Tissue Engineering

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