Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.

Abstract

The purpose of this research was to synthesize polymer based smart nanosystems for delivery of important bioactive natural products such as sesquiterpene coumarin derivatives of ferula szowitsiana, farnesiferol C as a potent anticancer. To this aim, polymeric micelles were prepared using Nisopropylacrylamide (NIPAAM), vinyl pyrrolidone (VP) and methacrylate (MAA) as monomers which were cross-linked with N, N-methylene bisacrylamide (MBA). The molar ratio of the PNIPAAm: VP: MAA group was 75.7:9.5:14.8. These micelles were further characterized upon their physicochemical properties using particle size analyzer, FT-IR, H-/C-NMR, HPLC. Particle size analyzer resulted in ~500 nm micelles with ~95% drug entrapments. Drug release from the polymeric micelles after 300 hours at 37°C and 40°C were 60 and 98 %, respectively. Upon these findings, it is proposed that the P (N-isopropylacrylamide-co-Methacrylic acid-coVinylpyrrolidone) micelles may be considered as thermosensitive delivery nanosystem.

Anti-proliferative and Apoptotic Effects of Dendrosomal Farnesiferol C on Gastric Cancer Cells

“…The rather low toxicity against normal cells versus cancerous cell lines has made coumarins as attractive candidates for the future anti-cancer medications (Lake et al, 1999). Among the large family of coumarins, the farnesiferol C (FC) is one of the sesquiterpene coumarin compounds that is isolated from the roots of Ferula szowitziana D.C (Shahverdi et al, 2007;Mashinchian et al, 2010). The plants of genus Ferula (Apiaceae) have distributed throughout central Asia, Mediterranean region and Northern Africa (Pimenov and Leonov, 1993) and well documented as a good source of bioactive compounds such as sesquiterpenes and coumarins (Zhou et al, 2000;Abd El-Razek et al, 2001;Iranshahi et al, 2004).…”

Sesquiterpene coumarins

“…Furthermore, in vivo growth of mouse Lewis lung cancer allograft was inhibited to 60% at a daily dosage of 1 mg/kg body weight of fanesiferol C (20) without negative effects on the weight of the host mice. Mashinchian et al (2010) described the synthesis of polymer based smart thermosensitive nanocarriers for delivery of natural active products. In this study, farnesiferol C (20) was used as a potent anticancer agent.…”

Chitosan‐based multifunctional nanomedicines and theranostics for targeted therapy of cancer

“…Moreover, some amphiphilic decorations were shown to enhance the capability of the CS‐based polymers for the production of self‐assembled NPs with greater specificity to the cell membrane elements . CS‐based NSs can also be engineered as stimuli‐responsive DDSs (through pH alteration, temperature induction, light irradiation, and ultrasound waves), which can provide controlled and on‐demand release of anticancer agents . In fact, the modification of CS could improve its original properties, resulting in optimized applications of these advanced materials in biomedical/pharmaceutical fields .…”

“…22 CS-based NSs can also be engineered as stimuli-responsive DDSs (through pH alteration, temperature induction, light irradiation, and ultrasound waves), which can provide controlled and on-demand release of anticancer agents. 23 In fact, the modification of CS could improve its original properties, resulting in optimized applications of these advanced materials in biomedical/pharmaceutical fields. [24][25][26] Figure 1 displays a schematic representation of CS-based multifunctional targeted NS for simultaneous imaging and therapy of cancer.…”