Novel Thiosialosides Tethered to Metal Nanoparticles as Potent Influenza a Virus Haemagglutinin Blockers

Fěng, Fang; Sakoda, Yoshihiro; Ohyanagi, Tatsuya; Nagahori, Noriko; Shibuya, Hitomi; Okamastu, Masatoshi; Miura, Nobuaki; Kida, Hiroshi; Nishimura, Shin‐Ichiro

doi:10.3851/imp2553

Cited by 17 publications

(11 citation statements)

References 38 publications

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“…Several synthetic glycoparticles carrying multivalent sialosides that target viral HAs have been reported in the literature as influenza virus inhibitors/detection probes using either gold, − silver, polyglycerol, , latex, or cyclic dextrins as the backbone. However, to date, these inhibitors or detection probes have been limited to glycoparticles obtained by immobilizing N -acetylneuraminic acid (Neu5Ac), a common sialic acid found on the surface of human cells.…”

Section: Results and Discussionmentioning

confidence: 99%

Application of Novel Sialoglyco Particulates Enhances the Detection Sensitivity of the Equine Influenza Virus by Real-Time Reverse Transcriptase Polymerase Chain Reaction

Ogata

Yamanaka

Koizumi

et al. 2019

ACS Appl. Bio Mater.

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Sialoglyco particulates carrying an N-glycolylneuraminyl-α-(2 → 3)-N-acetyllactosamine (Neu5Gcα2,3LacNAc) residue that displays a high level of affinity for the equine influenza virus (EIV) were generated using sialoglycopolypeptide and hexyl-containing hybrid silica particulates. The particulates were spherical with a diameter of approximately 950 nm and found to have good dispersibility in aqueous solution. Interaction between the sialoglyco particulates and the EIV was investigated by real-time reverse transcriptase polymerase chain reaction (rRT-PCR) of the EIV genome captured on the particulates. The number of EIV-specific genes detected by rRT-PCR on a nasal swab obtained from infected horses clearly increased when the sample was treated with sialoglyco particulates. Our results show these novel sialoglyco particulates can be used as a highly sensitive tool for detecting low levels of EIV that were previously undetectable in the early or late stage of infection.

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Section: Results and Discussionmentioning

confidence: 99%

Application of Novel Sialoglyco Particulates Enhances the Detection Sensitivity of the Equine Influenza Virus by Real-Time Reverse Transcriptase Polymerase Chain Reaction

Ogata

Yamanaka

Koizumi

et al. 2019

ACS Appl. Bio Mater.

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“…The formulation was effective against influenza. A virus [ 207 ]. Xiang et al, demonstrated the potential application of silver nanoparticles for the treatment of H3N2 influenza viruses, resulting in damage of the morphological structure of the viruses.…”

Section: Viral Infectionsmentioning

confidence: 99%

Metal-Based Nanoparticles for the Treatment of Infectious Diseases

2017

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Infectious diseases can be transmitted and they cause a significant burden on public health globally. They are the greatest world killers and it is estimated that they are responsible for the demise of over 17 million people annually. The impact of these diseases is greater in the developing countries. People with compromised immune systems and children are the most affected. Infectious diseases may be caused by bacteria, viruses, and protozoa. The treatment of infectious diseases is hampered by simultaneous resistance to multiple drugs, indicating that there is a serious and pressing need to develop new therapeutics that can overcome drug resistance. This review will focus on the recent reports of metal-based nanoparticles that are potential therapeutics for the treatment of infectious diseases and their biological efficacy (in vitro and in vivo).

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“…Similarly, Russell and co‐workers synthesized sialo‐AuNPs by using click chemistry to develop a biosensor for the detection of the influenza A virus (Figure d) . Nishimura and co‐workers employed an oxide‐coupling reaction between aminooxy‐functionalized AuNPs and a sialoside ketone linker to synthesize sialo‐AuNPs, which were used to detect the influenza A virus …”

Section: Sialo‐nanoparticlesmentioning

confidence: 99%

“…[69] Nishimura and co-workers employed an oxidecoupling reaction between aminooxy-functionalized AuNPs and as ialosidek etone linker to synthesize sialo-AuNPs, which were used to detect the influenza Avirus. [70] Gold and silver nanoparticles have similaro pticalp roperties, large surface areas, and good conductance. In addition, silver nanoparticles (AgNPs) display distinct antimicrobial activities.…”

Section: Sialo-nanoparticlesmentioning

confidence: 99%

Multivalent Sialosides: A Tool to Explore the Role of Sialic Acids in Biological Processes

Chaudhary

Toraskar

Yadav

et al. 2019

Chemistry An Asian Journal

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Sialic acids (Sias) are fascinating nine‐carbon monosaccharides that are primarily found on the terminus of the oligosaccharide chains of glycoproteins and glycolipids on cell surfaces. These Sias undergo a variety of structural modifications at their hydroxy and amine positions, thereby resulting in structural diversity and, hence, coordinating a variety of biological processes. However, deciphering the structural functions of such interactions is highly challenging, because the monovalent binding of Sias is extremely weak. Over the last decade, several multivalent Sia ligands have been synthesized to modulate their binding affinity with proteins/lectins. In this Minireview, we highlight recent developments in the synthesis of multivalent Sia probes and their potential applications. We will discuss four key multivalent families, that is, polymers, dendrimers, liposomes, and nanoparticles, and will emphasize the major parameters that are essential for the specific interactions of these molecules with proteins in biological systems.

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Novel Thiosialosides Tethered to Metal Nanoparticles as Potent Influenza a Virus Haemagglutinin Blockers

Abstract: Glycosylated metal nanoparticles were designed and synthesized as potent influenza A virus HA blockers. This study may contribute to the acceleration of the discovery of a new class of nanoparticle anti-influenza drugs.

Cited by 17 publications

References 38 publications

Application of Novel Sialoglyco Particulates Enhances the Detection Sensitivity of the Equine Influenza Virus by Real-Time Reverse Transcriptase Polymerase Chain Reaction

Application of Novel Sialoglyco Particulates Enhances the Detection Sensitivity of the Equine Influenza Virus by Real-Time Reverse Transcriptase Polymerase Chain Reaction

Metal-Based Nanoparticles for the Treatment of Infectious Diseases

Multivalent Sialosides: A Tool to Explore the Role of Sialic Acids in Biological Processes

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