Novel tissue adhesives to secure laser in situ keratomileusis flaps

Abstract

Two novel biodendrimer adhesives successfully sealed and secured LASIK flaps. These adhesives may prove to be an effective alternative for treating LASIK flap complications such as epithelial ingrowth or flap dislocation.

Tissue adhesives in ocular surgery

“…They have also demonstrated the use of the dendritic bio adhesive ([G1]-PGLSA-MA) 2 -PEG in numerous ocular applications including central corneal lacerations [143], clear corneal cataract incisions [144,145], flaps from LASIK surgery [146], scleral incisions [147] and 8-mm penetrating keratoplasties [148]. These in vitro studies tested the capability of this sealant to withstand high IOP (mean leakage pressure of 78.7 mmHg in lacerated cornea) [149].…”

“…One such adhesive developed consists of lysine-based peptide dendrons with N-terminal cysteine conjugates that react with poly-(ethylene glycol dialdehyde). This formulation was successfully applied for the repair of 3 mm clear corneal incisions [145] and sealing of LASIK flap edges [150] in enucleated eyes.…”

In Situ Polymerized Hydrogels for Repairing Scleral Incisions Used in Pars Plana Vitrectomy Procedures

“…[16][17][18][19] Using a photocurable hydrogel system based on poly(glycerol-succinic acid)-polyethylene glycol hybrid dendritic-linear macromolecules, full-thickness 4.1 mm corneal lacerations in enucleated eyes and chicken eyes in vivo, as well as secured LASIK flaps in vitro, have been successfully repaired. [19][20][21][22] In addition to light-activated hydrogel formation, other crosslinking strategies that quickly afford a hydrogel adhesive are also explored. [22,23] Herein, we report the synthesis of lysinetermA C H T U N G T R E N N U N G inated peptide dendrimers and dendrons, the formation of crosslinked hydrogels with a poly(ethylene glycol) di-activated ester, the analysis of hydrogel mechanical properties, and the closure of a sclerotomy incision-the wound created during a typical vitrectomy procedure.…”

“…[19][20][21][22] In addition to light-activated hydrogel formation, other crosslinking strategies that quickly afford a hydrogel adhesive are also explored. [22,23] Herein, we report the synthesis of lysinetermA C H T U N G T R E N N U N G inated peptide dendrimers and dendrons, the formation of crosslinked hydrogels with a poly(ethylene glycol) di-activated ester, the analysis of hydrogel mechanical properties, and the closure of a sclerotomy incision-the wound created during a typical vitrectomy procedure.…”

Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro

“…We have found that crosslinkable derivatives of these dendrimers are useful for the repair of ophthalmic wounds and articular cartilage (35,37,(40)(41)(42). Recently, we described the encapsulation characteristics of a poly(glycerol-succinic acid) (PGLSA) dendrimer and the use of this macromolecule as a potential vehicle for drug delivery (43).…”