Novel tools to speed up the technology commercialization process

Gembicki, Stanley A.; VandenBussche, Kurt M.; Oroskar, Anil R.

doi:10.1016/s0009-2509(02)00579-1

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…It consists of a microreactor with a high-resolution microbalance that generates real-time measurements of mass changes during gassolid reactions [6][7][8]. The TEOM measures mass changes based on inertial forces, presenting key advantages over conventional gravimetric microbalances: (i) a well-defined flow profile, eliminating possible (heat and mass) diffusion and buoyancy phenomena, (ii) a very fast response time resolution (0.1 s), and (iii) a high mass resolution across the entire range of pressure and temperature.…”

Section: Teom Studiesmentioning

confidence: 99%

Light alkanes CO2 reforming to synthesis gas over Ni based catalysts

et al. 2006

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The CO2 reforming of methane and propane has been compared over two different Ni catalysts: one reference Ni/SiO2 system and a Ni/Mg(Al)O hydrotalcite-derived catalyst, shown previously to display high catalytic stability for long term reforming. By combining the Tapered Element Oscillating Microbalance (TEOM), Temperature Programmed Hydrogenation (TPH), Transmission Electron Microscopy (TEM) and magnetic measurements, the formation of coke and its role on the catalyst activity has been investigated and compared for both hydrocarbons. It was found that Ni/SiO2 and Ni/Mg(Al)O are both more active for methane reforming than for propane reforming. Coke formation is much more pronounced for propane than for methane over both catalysts. However, for both hydrocarbons a much faster carbon formation is observed over the Ni/SiO2 catalyst than over the Ni/Mg(Al)O catalyst. The difference in the rates of coke formation for methane and propane is ascribed in the case of propane to partially dehydrogenated C3 adspecies, which are good coke precursors. The superior stability of the hydrotalcite-derived catalyst is due to the strong interaction of the nickel phase with the support and the capacity of the support to activate CO2 and channel oxygen to the nickel phase

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Section: Teom Studiesmentioning

confidence: 99%

Light alkanes CO2 reforming to synthesis gas over Ni based catalysts

et al. 2006

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“…This study also showed that very little sample (2 mg) is required in analyzing catalytic activity of samples that showed minimal (∼20% of that of Pt on alumina) to high conversion (equivalent to Pt on alumina at 100%) and, therefore, provides an alternative to screening using microreactors 22 for reactors that employ catalysts in the form of beads. Gembicki et al 23 argue that catalysts and reactors have evolved over the years to operate in a transient mode. The LAMIMS reactor inherently couples separation and reaction and can be adapted to run as a multifunctional transient reactor.…”

Section: Icp-ms Analysis Of Metal-loaded Beadsmentioning

confidence: 99%

Directed-Sorting Method for Synthesis of Bead-Based Combinatorial Libraries of Heterogeneous Catalysts

Ramanathan¹,

Chan²,

Salvitti³

et al. 2006

J. Comb. Chem.

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The synthesis and analysis of inorganic material combinatorial libraries by a directed-sorting, split-pool bead method was demonstrated. Directed-sorting, split-pool, metal-loaded libraries were synthesized by adsorbing metal salts (H 2 PtCl 6 , SnCl 2 , CuCl 2 , and NiCl 2 ) and metal standards (Pt, Cu, Ni in HCl) onto 2-mg porous γ-alumina beads in 96-or 384-well plates. A matrix algorithm for the synthesis of bead libraries treated each bead as a member of a row or column of a given matrix. Computer simulations and manual tracking of the sorting process were used to assess library diversity. The bead compositions were analyzed by energy-dispersive X-ray spectroscopy, X-ray fluorescence spectroscopy, electron probe microanalysis, inductively coupled plasma atomic emission spectroscopy, and inductively coupled plasma mass spectroscopy. The metal-loaded beads were analyzed by laser-activated membrane introduction mass spectroscopy (LAMIMS) for catalytic activity using methylcyclohexane dehydrogenation to toluene as a probe reaction. The catalytic activity of individual beads that showed minimal (∼20% of that of Pt on alumina) to high conversion could be determined semiquantitatively by LAMIMS. This method, therefore, provides an alternative to screening using microreactors for reactors that employ catalysts in the form of beads. The directed-sorting method offers the potential for synthesis of focused libraries of inorganic materials through relatively simple benchtop split-pool chemistry.

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“…The possibilities of full instrumentation, analysis and automation for precision control spurred on the explorations for process development, new ways of organic synthesis, material synthesis, catalyst development, testing and comparative evaluation, polymerization, biosynthesis, etc. Copyright (1995 American Chemical Society) Shannon, et al, (1995 Gembicki et al, 2003, Copyright (2003, with permission from Elsevier) Cleaves and Centi (1993); Yablonskii et al, (1998);Gembicki et al, (2003). Richardson et al, 1978.…”

Section: Microreactors: Generalmentioning

confidence: 99%

“…• Allows wide range of flow rates and maintaining of desired hydrodynamic and temperature regime (Reprinted from Gembicki et al, 2003, Copyright (2003, with permission from Elsevier) Gembicki et al, 2003, Copyright (2003, with permission from Elsevier) Gembicki et al, (2003 Lamping et al, 2003, Copyright (2003, with permission from Elsevier) Kostov et al, (2001); Lamping et al, (2003 …”

Section: High Throughput Screening (Hts)mentioning

confidence: 99%

Microchannel Reactors: Applications and Use in Process Development

Gokhale¹,

Tayal²,

Jayaraman³

et al. 2005

International Journal of Chemical Reactor Engineering

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Recent research results on microchannel reactors are reviewed with particular reference to their applications and use as a cost effective tool during process development tasks. The high surface to volume ratio, efficient heat and mass transfer characteristics, vastly improved fluid mixing etc., allow precision control of reaction with improved conversions, selectivities and yields of desired products. The reaction times are shorter as compared to the conventional reactors with less degradation and side products. Scalability and optimization are also significantly easier. The article reviews variety of applications to catalysis, polymers, advanced materials, biosystems, organic reaction etc., with emphasis on the related engineering science issues.

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Novel tools to speed up the technology commercialization process

Cited by 9 publications

References 10 publications

Light alkanes CO2 reforming to synthesis gas over Ni based catalysts

Light alkanes CO2 reforming to synthesis gas over Ni based catalysts

Directed-Sorting Method for Synthesis of Bead-Based Combinatorial Libraries of Heterogeneous Catalysts

Microchannel Reactors: Applications and Use in Process Development

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