Novel topical drug delivery systems in acne management: Molecular mechanisms and role of targeted delivery systems for better therapeutic outcomes

Ghasemiyeh, Parisa; Mohammadi-Samani, Soliman; Noorizadeh, Kiarash; Zadmehr, Ouriel; Rasekh, Shiva; Mohammadi-Samani, Shiva; Dehghan, Dorsa

doi:10.1016/j.jddst.2022.103595

Cited by 15 publications

(7 citation statements)

References 144 publications

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“…It offers several advantages, including safety, environmental friendliness (as it is free of organic solvents), and simplicity in preparation. Anti-acne studies demonstrated that the DES formulation exhibited inhibition zones comparable to those of the commercially available cream and previously reported formulations [15,34,45].…”

Section: Stability Resultssupporting

confidence: 69%

The Formulation and Evaluation of Deep Eutectic Vehicles for the Topical Delivery of Azelaic Acid for Acne Treatment

Luhaibi,

Ali,

Al-Ani

et al. 2023

Molecules

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The current work was aimed at the development of a topical drug delivery system for azelaic acid (AzA) for acne treatment. The systems tested for this purpose were deep eutectic systems (DESs) prepared from choline chloride (CC), malonic acid (MA), and PEG 400. Three CC to MA and eight different MA: CC: PEG400 ratios were tested. The physical appearance of the tested formulations ranged from solid and liquid to semisolid. Only those that showed liquid formulations of suitable viscosity were considered for further investigations. A eutectic mixture made from MA: CC: PEG400 1:1:6 (MCP 116) showed the best characteristics in terms of viscosity, contact angle, spreadability, partition coefficient, and in vitro diffusion. Moreover, the MCP116 showed close rheological properties to the commercially available market lead acne treatment product (Skinorin®). In addition, the formula showed synergistic antibacterial activity between the MA moiety of the DES and the AzA. In vitro diffusion studies using polyamide membranes demonstrated superior diffusion of MCP116 over the pure drug and the commercial product. No signs of skin irritation and edema were observed when MCP116 was applied to rabbit skin. Additionally, the MCP116 was found to be, physically and chemically, highly stable at 4, 25, and 40 °C for a one-month stability study.

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Section: Stability Resultssupporting

confidence: 69%

The Formulation and Evaluation of Deep Eutectic Vehicles for the Topical Delivery of Azelaic Acid for Acne Treatment

Luhaibi,

Ali,

Al-Ani

et al. 2023

Molecules

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“…In the diffusion-based release process, bioactive molecules move through the hydrogel matrix from a high-concentration reservoir, resulting in constant-rate and timeindependent release profiles. In contrast, hydrogel delivery systems exhibit time-dependent bioactive release profiles [53,113]. Typically, diffusion-based release cannot sustain drug release for extended periods, typically lasting only a few hours to a day [53].…”

Section: Classification Of Pva Hydrogel As Smart Delivery Mediamentioning

confidence: 99%

Bioactive compounds-loaded polyvinyl alcohol hydrogels: advancements in smart delivery media for biomedical applications

Luthfianti,

Waresindo,

Edikresnha

et al. 2024

Mater. Res. Express

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The paper initially focuses on the characteristics of Polyvinyl Alcohol (PVA) hydrogel as smart delivery media, such as chemical stability, biocompatibility, and capacity for controlled release of bioactive compounds. Then, it discusses the effect of loading bioactive compounds into PVA hydrogel, considering their stability of delivery media, controlled release, and targeted delivery, enhancing therapeutic outcomes. Loading bioactive compounds such as diphlorethohydroxycarmalol (DPHC), curcumin, carotenoids, andrographolide, and flavonoids into PVA hydrogels can enhance biomedical functionalities. These functionalities include improved drug delivery, wound dressing efficacy, tissue engineering potential, and contact lens applications. Further, while previous review papers have extensively covered aspects such as the source of bioactive compounds, extraction methods, synthesis of PVA hydrogel, and various biomedical applications, there remains a gap in the literature in which no studies have systematically explored the loading of bioactive compounds into PVA hydrogel. This targeted investigation distinguishes our work from previous studies and contributes a novel perspective to the expanding hydrogel market. In light of the projected compound annual growth rate of 7.15% in the hydrogel market from 2021 to 2028, this study provides a pioneering overview of recent advancements in bioactive compound-loaded PVA hydrogels. Finally, this review outlines the challenges in optimizing bioactive compound-loaded PVA hydrogels' performance and their biomedical application. In the future direction, this review explores their potential in smart delivery media, such as optimizing the loading efficiency and releasing kinetics to specific target therapeutic, crosslinking with double or triple network hydrogels, and convergence of nanotechnology with hydrogel that become frontiers in precision medicine.

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“…Moreover, Ghasemiyeh, P. et al reported that the controlled mechanism of drug release from hydrogel can be divided into three categories: diffusion-controlled, swelling-controlled and polymer-degraded release [50]. However, these mechanisms are described by the n values from the Korsmeyer-Peppas model.…”

Section: Analysis Of the Drug Transport Mechanismmentioning

confidence: 99%

Synthesis and characterization of semi-IPN hydrogels composed of sodium 2-acrylamido-2-methylpropanesulfonate and poly(ε-caprolactone) diol for controlled drug delivery

Rungrod

Kapanya

Punyodom

et al. 2022

European Polymer Journal

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Novel topical drug delivery systems in acne management: Molecular mechanisms and role of targeted delivery systems for better therapeutic outcomes

Cited by 15 publications

References 144 publications

The Formulation and Evaluation of Deep Eutectic Vehicles for the Topical Delivery of Azelaic Acid for Acne Treatment

The Formulation and Evaluation of Deep Eutectic Vehicles for the Topical Delivery of Azelaic Acid for Acne Treatment

Bioactive compounds-loaded polyvinyl alcohol hydrogels: advancements in smart delivery media for biomedical applications

Synthesis and characterization of semi-IPN hydrogels composed of sodium 2-acrylamido-2-methylpropanesulfonate and poly(ε-caprolactone) diol for controlled drug delivery

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