Novel transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation

Sohn, Wern‐Joo; Kim, Dongbum; Lee, Keun-Wook; Kim, Min‐Soo; Kwon, Sang-Hoon; Lee, Younghee; Kim, Doo-Sik; Kwon, Hyung‐Joo

doi:10.1016/j.molimm.2007.03.001

Cited by 49 publications

(44 citation statements)

References 27 publications

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“…Besides these cell types, Slfn genes are expressed in diverse mammalian tissues, with a clear preference for those related with the immune system, which agrees with a role of the Slfn genes in immune cells development and functioning (1,3,4,34). In addition, changes in the RNA levels of diverse Slfn members have been observed during the development of cells of the immune system and in response to infections by several pathogens wand related molecules such as the lipopolysaccharide (LPS)x, including viruses (1,4,(34)(35)(36)(37)(38)(39)(40)(41)(42).…”

Section: Expression and Phenotypes Associated To The Mammalian Schlafsupporting

confidence: 70%

“…Whereas interferon-g (IFN-g) does not appear to affect these expression changes, it leads to upregulation of several Slfn genes in macrophages (4); in contrast, Slfn4 has been reported to be a type I IFN target (42). LPS and CpG-DNA stimulations also induce the expression of several Slfn members in both mouse and human macrophages (4,40,42).…”

Section: The Schlafen Family Roles In Immune Cells Development and Fumentioning

confidence: 99%

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From mammals to viruses: the Schlafen genes in developmental, proliferative and immune processes

Casa-Esperón

2011

BioMolecular Concepts

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The Schlafen genes have been associated with proliferation control and with several differentiation processes, as well as with disparate phenotypes such as immune response, embryonic lethality and meiotic drive. They constitute a gene family with widespread distribution in mammals, where they are expressed in several tissues, predominantly those of the immune system. Moreover, horizontal transfer of these genes to orthopoxviruses suggests a role of the viral Schlafens in evasion to the host immune response. The expression and functional studies of this gene family will be reviewed under the prism of their evolution and diversification, the challenges they pose and the future avenues of research.

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Section: Expression and Phenotypes Associated To The Mammalian Schlafsupporting

confidence: 70%

Section: The Schlafen Family Roles In Immune Cells Development and Fumentioning

confidence: 99%

From mammals to viruses: the Schlafen genes in developmental, proliferative and immune processes

Casa-Esperón

2011

BioMolecular Concepts

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“…Slfn-1 and Slfn-2 were originally implicated in fibroblast growth arrest but it seems more likely that they play a role in hematopoetic development and immune responses. The fact that Slfn-2 can be induced in Mf by stimulation with LPS or CpG [32] strengthens such notions. Little is known about Slfn-4, one of the most strongly induced genes in H37Rv-infected iNOS -/-mice, but involvement in lung alveolarization has been reported [33].…”

Section: Adaptive Immune Responsementioning

confidence: 66%

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Beisiegel¹,

Mollenkopf²,

Hahnke³

et al. 2009

Eur J Immunol

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Progression and outcome of tuberculosis is governed by extensive crosstalk between pathogen and host. Analyses of global changes in gene expression during immune response to infection with Mycobacterium tuberculosis (M.tb) can help identify molecular markers of disease state and progression. Global distribution of M.tb strains with different degrees of virulence and drug resistance, especially for the immunocompromised host, make closer analyses of host responses more pressing than ever. Here, we describe global transcriptional responses of inducible nitric oxide synthase-deficient (iNOS -/-) and WT mice infected with two related M.tb strains of markedly different virulence, namely the M.tb laboratory strains H37Rv and H37Ra. Both hosts exhibited highly similar resistance to infection with H37Ra. In contrast, iNOS -/-mice rapidly succumbed to H37Rv, whereas WT mice developed chronic course of disease. By differential analyses, virulence-specific changes in global host gene expression were analyzed to identify molecular markers characteristic for chronic versus acute infection. We identified several markers unique for different stages of disease progression and not previously associated with virulencespecific host responses in tuberculosis.

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“…Slfn2 protein appears to play a role in maintaining quiescence in cells of the immune response, as mice harboring a Slfn2 mutation (elektra) are more susceptible to both bacterial and viral infections, which is a consequence of T cells undergoing apoptosis via the intrinsic pathway (10). More evidence that Slfn2 is involved in the immune response is the observation that this member of the Slfn family is up-regulated by LPS, in an NF-kBand AP-1-dependent manner (6). There is also recent evidence that Slfn2 is an IFN-inducible gene and suppresses cyclin D1 expression, suggesting that it plays an important role in the control of cell cycle progression (9).…”

Section: There Is Emerging Evidence That the Ifn-inducible Family Ofmentioning

confidence: 99%

Expression and Regulatory Effects of Murine Schlafen (Slfn) Genes in Malignant Melanoma and Renal Cell Carcinoma

Mavrommatis

Arslan

Sassano

et al. 2013

Journal of Biological Chemistry

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Background:The role of Slfn genes in antineoplastic responses is yet to be defined. Results: Murine Slfn genes are up-regulated in an IFN-dependent manner in melanoma, and RCC cells and members of this family differentially suppress proliferation and anchorage-independent malignant cell growth. Conclusion: Slfns play important roles in controlling malignant melanoma and RCC tumorigenesis. Significance: Modulation of Slfn expression may provide a novel approach for the treatment of malignancies.

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Novel transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation

Cited by 49 publications

References 27 publications

From mammals to viruses: the Schlafen genes in developmental, proliferative and immune processes

From mammals to viruses: the Schlafen genes in developmental, proliferative and immune processes

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Expression and Regulatory Effects of Murine Schlafen (Slfn) Genes in Malignant Melanoma and Renal Cell Carcinoma

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