Novel transcutaneous sensor combining optical tcPO2 and electrochemical tcPCO2 monitoring with reflectance pulse oximetry

Abstract

This study investigated the accuracy, drift, and clinical usefulness of a new optical transcutaneous oxygen tension (tcPO 2) measuring technique, combined with a conventional electrochemical transcutaneous carbon dioxide (tcPCO 2) measurement and reflectance pulse oximetry in the novel transcutaneous OxiVenT™ Sensor. In vitro gas studies were performed to measure accuracy and drift of tcPO 2 and tcPCO 2. Clinical usefulness for tcPO 2 and tcPCO 2 monitoring was assessed in neonates. In healthy adult volunteers, measured oxygen saturation values (SpO 2) were compared with arterially sampled oxygen saturation values (SaO 2) during controlled hypoxemia. In vitro correlation and agreement with gas mixtures of tcPO 2 (r = 0.999, bias 3.0 mm Hg, limits of agreement − 6.6 to 4.9 mm Hg) and tcPCO 2 (r = 0.999, bias 0.8 mm Hg, limits of agreement − 0.7 to 2.2 mm Hg) were excellent. In vitro drift was negligible for tcPO 2 (0.30 (0.63 SD) mm Hg/24 h) and highly acceptable for tcPCO 2 (− 2.53 (1.04 SD) mm Hg/12 h). Clinical use in neonates showed good usability and feasibility. SpO 2-SaO 2 correlation (r = 0.979) and agreement (bias 0.13%, limits of agreement − 3.95 to 4.21%) in healthy adult volunteers were excellent. The investigated combined tcPO 2 , tcPCO 2 , and SpO 2 sensor with a new oxygen fluorescence quenching technique is clinically usable and provides good overall accuracy and negligible tcPO 2 drift. Accurate and low-drift tcPO 2 monitoring offers improved measurement validity for long-term monitoring of blood and tissue oxygenation. Keywords Transcutaneous. tcPO 2. tcPCO 2. Oxygen. Fluorescence quenching * Willem van Weteringen

Validation of a New Transcutaneous tcPO₂/tcPCO₂ Sensor with an Optical Oxygen Measurement in Preterm Neonates

“…In previous studies, the large variation in patient populations, applied sensor temperatures, and mixed inclusion of capillary and arterial samples have led to a large spread in, often contradicting, study results [15]. Recently, a new transcutaneous sensor has been introduced, featuring an optical fluorescence quenching oxygen measurement, combined with a conventional electrochemical carbon dioxide sensor [16]. The fluorescence quenching technique measures oxygen levels through fluorescence decay of a dye that is quenched by oxygen, resulting in reduced fluorescence intensity and decay rates [17].…”

Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis: a first-in-human clinical trial

“…This clinical trial that aimed at testing two sensors for the monitoring of and allowed us to investigate their implementation on the same platform. 21 Regarding the CMOS-DRS sensor, this clinical trial and the comparison with reference sensors helped us to understand the estimation discrepancy previously seen. 7 Results obtained assess the potential of the system for in vivo tissue oxygenation monitoring in clinical settings.…”

“…This trial aimed at testing two sensors that will eventually be on the same platform to measure two physiological parameters: partial pressure of carbon dioxide ( ) and . 21 The clinical trial has been performed in collaboration with INSERM & CHU Grenoble University Hospital. It was planned to acquire data on a panel of 20 healthy volunteers [male and female, nonsmoker (attested by exhaled ), free from any disease and medication except contraceptives, IMC (body mass index) ] aged from 20 to 50 years old.…”

Current state of noninvasive, continuous monitoring modalities in pediatric anesthesiology

“…Transcutaneous sensors locally heat the skin improving diffusion of oxygen and CO 2 through the skin [ 56 ]. This results in a close approximation of arterial values, although accuracy on oxygen measurements is restricted due to limited diffusion capacity and due to increasing skin thickness with age [ 57 ▪ , 58 ]. It is mostly used on neonatal and pediatric ICUs.…”