Novel Translational Research Methodology and the Prospect to a Better Understanding of Neurodegenerative Disease

Unschuld, Paul G.

doi:10.1159/000486565

Cited by 6 publications

(5 citation statements)

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“…In recent years, oxidative stress‐related neurodegenerative diseases have been a rising lethal threat to human being (Unschuld, 2018). Numerous researches have shown that susceptibility of an individual to neurodegenerative diseases is persistently associated with the oxidative stress status of the body (Li & Yang, 2018).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of phenolics, capsaicinoids, antioxidant properties, and major macro‐micro minerals of some hot and sweet peppers and ginger land‐races of Malaysia

Alam

Saleh

Mohsin

et al. 2020

J Food Process Preserv

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There are compelling evidences that oxidative stress plays important role in age‐related neurodegenerative diseases and natural food‐derived dietary antioxidants appear to be the first line of defence to take care of the oxidative stress. The analysis results of this study showed that Cili Burung of the hot pepper landraces contained the highest amount of TPC (1.00 mg/g DW), TFC (0.17 mg/g DW), capsaicinoids (0.05 mg/g), and the highest FRAP activity (439 mg/g DW). However, DPPH assay revealed the highest DPPH scavenging activity (IC50 = 250 μg/ml) in Halia Bara rhizome. Rhizomes of both landraces of ginger showed a significant amount of capsaicinoids. Hot pepper Cili Ungu (5.50 g/kg) and sweet pepper Cili Kulai had the highest P contents (~5.5 g/kg). Halia Bentong ginger rhizome had the highest content of K (33.84 g/kg); however, Halia Bentong ginger roots had remarkably greater contents of Ca (10.96 g/kg). Ginger rhizomes and roots had greater contents of micro minerals compared to hot and sweet chili peppers. Ginger roots contained good amounts of bioactive compounds and mineral nutrients indicating its commercial value. Practical applications The findings of the research are truly very informative and potential for a greater health benefits of all types of health conscious generation of all ages. Depending on the greater contents of the measured bioactive compounds (total phenolics, flavonoids, capsaicinoids, and mineral nutrients) in Chili Burung from among the hot peppers and Cili Solok from among the sweet peppers and both ginger landraces may thus be suitable for commercial production and can serve as potential parents in breeding programs for enhanced phytonutrients constituents, or for use in related research. The presence of high phenolic and flavonoid contents in Chili Burung and gingers indicated their potentiality in pharmaceutical and ethnomedicinal uses. A good amount of bioactive compounds in ginger roots indicated its commercial value. And this is the first research reported on capsaicin in ginger; however, our findings do not preclude chemo‐profiling of capsaicinoids in ginger rhizomes for its inevitability.

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Section: Introductionmentioning

confidence: 99%

Evaluation of phenolics, capsaicinoids, antioxidant properties, and major macro‐micro minerals of some hot and sweet peppers and ginger land‐races of Malaysia

Alam

Saleh

Mohsin

et al. 2020

J Food Process Preserv

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show abstract

“…Au cours des vingt dernières années, ces nouveaux développements ont permis de cartographier les processus de vieillissement pathologique du cerveau chez les patients au cours de leur vie, et ainsi de mieux comprendre le lien avec les circonstances de la vie, dont certaines peuvent être facilement influencées. 5 La mise au point de séquences d'IRM permettant de visualiser les modifications des petits vaisseaux sanguins a permis de comprendre comment leur fonction non altérée est liée au fonctionnement de divers groupes de neurones dans le cerveau humain. 6-8 Alors que les infarctus cérébraux étendus entraînent des déficits neurologiques évidents, nous savons maintenant que ce sont les modifications des petits vaisseaux sanguins du cerveau qui peuvent entraîner des pertes lentement progressives des performances cognitives.…”

Section: Amélioration Des Diagnosticsunclassified

Prévention de la maladie d’Alzheimer : importance du mode de vie et interventions thérapeutiques précoces

Unschuld¹

2021

Revue Médicale Suisse

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“…Alzheimer's disease (AD) is a complicated and prevalent neurodegenerative disease that commonly occurs among older adults globally[ 1 , 2 ]. It is characterized by a progressive decline in cognitive ability and memory loss[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease

Lu,

Ma,

Jiang

et al. 2024

World J Psychiatry

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BACKGROUND Epidemiological studies have revealed a correlation between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2D). Insulin resistance in the brain is a common feature in patients with T2D and AD. KAT7 is a histone acetyltransferase that participates in the modulation of various genes. AIM To determine the effects of KAT7 on insulin patients with AD. METHODS APPswe/PS1-dE9 double-transgenic and db/db mice were used to mimic AD and diabetes, respectively. An in vitro model of AD was established by Aβ stimulation. Insulin resistance was induced by chronic stimulation with high insulin levels. The expression of microtubule-associated protein 2 (MAP2) was assessed using immunofluorescence. The protein levels of MAP2, Aβ, dual-specificity tyrosine phosphorylation-regulated kinase-1A (DYRK1A), IRS-1, p-AKT, total AKT, p-GSK3β, total GSK3β, DYRK1A, and KAT7 were measured via western blotting. Accumulation of reactive oxygen species (ROS), malondialdehyde (MDA), and SOD activity was measured to determine cellular oxidative stress. Flow cytometry and CCK-8 assay were performed to evaluate neuronal cell death and proliferation, respectively. Relative RNA levels of KAT7 and DYRK1A were examined using quantitative PCR. A chromatin immunoprecipitation assay was conducted to detect H3K14ac in DYRK1A. RESULTS KAT7 expression was suppressed in the AD mice. Overexpression of KAT7 decreased Aβ accumulation and MAP2 expression in AD brains. KAT7 overexpression decreased ROS and MDA levels, elevated SOD activity in brain tissues and neurons, and simultaneously suppressed neuronal apoptosis. KAT7 upregulated levels of p-AKT and p-GSK3β to alleviate insulin resistance, along with elevated expression of DYRK1A. KAT7 depletion suppressed DYRK1A expression and impaired H3K14ac of DYRK1A. HMGN1 overexpression recovered DYRK1A levels and reversed insulin resistance caused by KAT7 depletion. CONCLUSION We determined that KAT7 overexpression recovered insulin sensitivity in AD by recruiting HMGN1 to enhance DYRK1A acetylation. Our findings suggest that KAT7 is a novel and promising therapeutic target for the resistance in AD.

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Novel Translational Research Methodology and the Prospect to a Better Understanding of Neurodegenerative Disease

Cited by 6 publications

References 50 publications

Evaluation of phenolics, capsaicinoids, antioxidant properties, and major macro‐micro minerals of some hot and sweet peppers and ginger land‐races of Malaysia

Evaluation of phenolics, capsaicinoids, antioxidant properties, and major macro‐micro minerals of some hot and sweet peppers and ginger land‐races of Malaysia

Prévention de la maladie d’Alzheimer : importance du mode de vie et interventions thérapeutiques précoces

KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease

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