Novel Treatment of Neuroinflammation Against Low Back Pain by Soluble Fullerol Nanoparticles

Liu, Qihai; Jin, Li; Mahon, Brian H.; Chordia, Mahendra D.; Shen, Francis H.; Li, Xudong

doi:10.1097/brs.0b013e31828fc6b7

Cited by 29 publications

(46 citation statements)

References 51 publications

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“…(101, 102) Novel treatments targeting inflammation are being pursued. (103, 104) The high levels of proinflammatory mediators found in disc tissue from patients undergoing fusion for discogenic back pain suggest that production of proinflammatory mediators within the IVD may be a major factor in the genesis of a painful lumbar disc. (11, 12, 98, 99) These findings strongly suggest that in addition to the commonly used histology and extracellular matrix composition, inflammatory markers may be used as outcome measures in response to cell therapy.…”

Section: Role Of Inflammation In Ivd Degeneration and Back Painmentioning

confidence: 99%

Cell therapy for the degenerating intervertebral disc

Tong

Qin

et al. 2017

Translational Research

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Section: Role Of Inflammation In Ivd Degeneration and Back Painmentioning

confidence: 99%

Cell therapy for the degenerating intervertebral disc

Tong

Qin

et al. 2017

Translational Research

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“…The radical scavening ability of fullerenols has even been used to treat lower back pain effectively. 102 15 Highly iodinated and water-soluble C 60 derivative for X-ray imaging Photodynamic therapy (PDT)…”

Section: Antioxidantsmentioning

confidence: 99%

Water-soluble fullerenes for medical applications

Rašović

2017

Materials Science and Technology

119

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Research on fullerenes occupies a unique position in the scientific arena. Synthesis and characterisation of this nanomaterial blur the line between materials science and chemistry; careful tuning of the processing methods gives birth to a whole family of molecules and their functionalised derivatives, whose unusual properties at this nanoscopic scale can be exploited in cutting-edge technological applications. This review focuses on the functionalisation of fullerenes for use in medical applications. The first half gives an introduction to the fullerenes themselves and how their fundamental properties lead to a very rich chemistry, enabling both exohedral (external) and endohedral (internal) functionalisations of the cage. Emphasis is placed on the need for safe and reproducible synthesis routes if fullerenes are ever going to make it to the pharmaceutical market. In line with this, a selection of exohedral functionalisation protocols receives particular attention. Coverage of endohedral fullerene synthesis routes is limited to the endohedral metallofullerenes. In the second half, myriad applications of fullerenes in biomedical contexts are introduced and certain synthesis routes are critically evaluated. Discussion of the need to water solubilise the hydrophobic fullerene cages precedes an overview of fullerene-based diagnostic and therapeutic technologies. A final moment is spent on toxicity studies of fullerenes. The concluding remarks emphasise the positive effects of incorporating fullerenes into biomedical technologies, while looking at how these are perceived by the general public. A case is made for fullerenes being the optimal choice as standard bearers in the advance of nanomaterials into the medical field. This is the winning review of the 2016 Materials Literature Review Prize of the Institute of Materials, Minerals and Mining, run by the Editorial Board of MST. Sponsorship of the prize by TWI Ltd is gratefully acknowledged.

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“…31 Our present data showed that fullerol served as an antioxidant in human ADSCs without cytotoxicity at doses up to 10 µM (Figures 1 and 2), and this is in agreement with a majority of previous reports with regards to other tissues and cell types. [17][18][19]28,[32][33][34][35][36][37][38][39] It has been shown that ROS inhibit osteogenesis and bone formation. Mody et al 40 reported that three oxidants, hydrogen peroxide (H 2 O 2 ), xanthine, and xanthine oxidase, and minimally oxidized low-density lipoproteins inhibited osteoblastic differentiation of MC3T3-E1 mouse bone preosteoblast cell line and M2-10B4 mouse marrow stromal cell line, while increasing intracellular oxidative stress.…”

mentioning

confidence: 99%

“…Fullerol promotes osteogenesis water solubility, 19,[28][29][30] fullerol has been considered as a candidate with priority for the biomedical purpose of fullerenes. 31 Our present data showed that fullerol served as an antioxidant in human ADSCs without cytotoxicity at doses up to 10 µM (Figures 1 and 2), and this is in agreement with a majority of previous reports with regards to other tissues and cell types.…”

mentioning

confidence: 99%

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

Yang¹,

Li²,

Wan³

et al. 2014

IJN

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Antioxidants were implicated as potential reagents to enhance osteogenesis, and nano-fullerenes have been demonstrated to have a great antioxidative capacity by both in vitro and in vivo experiments. In this study, we assessed the impact of a polyhydroxylated fullerene, fullerol, on the osteogenic differentiation of human adipose-derived stem cells (ADSCs). Fullerol was not toxic against human ADSCs at concentrations up to 10 μM. At a concentration of 1 μM, fullerol reduced cellular reactive oxygen species after a 5-day incubation either in the presence or in the absence of osteogenic media. Pretreatment of fullerol for 7 days increased the osteogenic potential of human ADSCs. Furthermore, when incubated together with osteogenic medium, fullerol promoted osteogenic differentiation in a dose-dependent manner. Finally, fullerol proved to promote expression of FoxO1, a major functional isoform of forkhead box O transcription factors that defend against reactive oxygen species in bone. Although further clarification of related mechanisms is required, the findings may help further development of a novel approach for bone repair, using combined treatment of nano-fullerol with ADSCs.

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Novel Treatment of Neuroinflammation Against Low Back Pain by Soluble Fullerol Nanoparticles

Cited by 29 publications

References 51 publications

Cell therapy for the degenerating intervertebral disc

Cell therapy for the degenerating intervertebral disc

Water-soluble fullerenes for medical applications

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

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